No volatile n-nitrosamines detected in blood and urine from patients ingesting daily large amounts of ammonium nitrate
Whole blood and urine from 23 patients ingesting ammonium nitrate daily in amounts varying from 2.5–9 g were analysed for volatile N-nitrosamines. By contrast with reports in the literature N-nitrosodimethylamine and N-nitrosodiethylamine were not found in blood (limit of detection 0.1 μg/kg) but a...
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| Veröffentlicht in: | Food and chemical toxicology 1982-01, Vol.20 (6), p.879-882 |
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| container_issue | 6 |
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| container_title | Food and chemical toxicology |
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| creator | ellen, G. schuller, P.L. froeling, P.G.A.M. bruijns, E. |
| description | Whole blood and urine from 23 patients ingesting ammonium nitrate daily in amounts varying from 2.5–9 g were analysed for volatile
N-nitrosamines. By contrast with reports in the literature
N-nitrosodimethylamine and
N-nitrosodiethylamine were not found in blood (limit of detection 0.1 μg/kg) but a trace of
N-nitrosopyrrolidine was found in the blood of one subject. Small amounts of
N-nitrosomorpholine in some blood samples and in one blank were believed to be formed during the analysis since morpholine had been added to the samples to indicate artefactual nitrosamine formation. Traces of
N-nitrosodimethylamine (0.1 μg/kg) were found in six of the 23 urine samples. |
| doi_str_mv | 10.1016/S0015-6264(82)80221-6 |
| format | Article |
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N-nitrosamines. By contrast with reports in the literature
N-nitrosodimethylamine and
N-nitrosodiethylamine were not found in blood (limit of detection 0.1 μg/kg) but a trace of
N-nitrosopyrrolidine was found in the blood of one subject. Small amounts of
N-nitrosomorpholine in some blood samples and in one blank were believed to be formed during the analysis since morpholine had been added to the samples to indicate artefactual nitrosamine formation. Traces of
N-nitrosodimethylamine (0.1 μg/kg) were found in six of the 23 urine samples.</description><identifier>ISSN: 0278-6915</identifier><identifier>EISSN: 1873-6351</identifier><identifier>DOI: 10.1016/S0015-6264(82)80221-6</identifier><identifier>PMID: 6891671</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Adolescent ; Adult ; Female ; food contamination ; Humans ; Male ; Middle Aged ; Nitrates - administration & dosage ; Nitrates - metabolism ; Nitrosamines - blood ; Nitrosamines - isolation & purification ; Nitrosamines - urine ; Volatilization</subject><ispartof>Food and chemical toxicology, 1982-01, Vol.20 (6), p.879-882</ispartof><rights>1982 Pergamon Press Limited</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c384t-b09fce9ba2044bc628e7656b8c205934896e812a2fa4a446c0f96b4a6440b44f3</citedby><cites>FETCH-LOGICAL-c384t-b09fce9ba2044bc628e7656b8c205934896e812a2fa4a446c0f96b4a6440b44f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0015626482802216$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6891671$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ellen, G.</creatorcontrib><creatorcontrib>schuller, P.L.</creatorcontrib><creatorcontrib>froeling, P.G.A.M.</creatorcontrib><creatorcontrib>bruijns, E.</creatorcontrib><title>No volatile n-nitrosamines detected in blood and urine from patients ingesting daily large amounts of ammonium nitrate</title><title>Food and chemical toxicology</title><addtitle>Food Chem Toxicol</addtitle><description>Whole blood and urine from 23 patients ingesting ammonium nitrate daily in amounts varying from 2.5–9 g were analysed for volatile
N-nitrosamines. By contrast with reports in the literature
N-nitrosodimethylamine and
N-nitrosodiethylamine were not found in blood (limit of detection 0.1 μg/kg) but a trace of
N-nitrosopyrrolidine was found in the blood of one subject. Small amounts of
N-nitrosomorpholine in some blood samples and in one blank were believed to be formed during the analysis since morpholine had been added to the samples to indicate artefactual nitrosamine formation. Traces of
N-nitrosodimethylamine (0.1 μg/kg) were found in six of the 23 urine samples.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Female</subject><subject>food contamination</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Nitrates - administration & dosage</subject><subject>Nitrates - metabolism</subject><subject>Nitrosamines - blood</subject><subject>Nitrosamines - isolation & purification</subject><subject>Nitrosamines - urine</subject><subject>Volatilization</subject><issn>0278-6915</issn><issn>1873-6351</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1982</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE9v1DAQxS0EKtvCR6jwCcEhMHaciXNCqIKCVMGh9Gw5znhllMSLnazUb4_TXXHl4rH03ps_P8auBXwQIPDjPYBoKpSo3mn5XoOUosJnbCd0W1dYN-I524FsdYWdaF6yy5x_A0ArWrxgF6g7ga3YseOPyI9xtEsYic_VHJYUs53CTJkPtJBbaOBh5v0Y48DtPPA1FZH7FCd-KDGal1wMe8pLeflgw_jIR5v2xO0U102NvnynOId14tsAu9Ar9sLbMdPrc71iD1-__Lr5Vt39vP1-8_mucrVWS9VD5x11vZWgVO9QamqxwV47CU1XK90haSGt9FZZpdCB77BXFpWCXilfX7G3p76HFP-sZUczhexoHO1Mcc2mYCu4QBdjczK6cn9O5M0hhcmmRyPAbLzNE2-z8TZamifeBkvu-jxg7Sca_qXOgIv-5qR7G43dp5DNw70EUYNEUat6c3w6OahwOAZKJrtC1dEQUsFvhhj-s8NfB_aaXw</recordid><startdate>19820101</startdate><enddate>19820101</enddate><creator>ellen, G.</creator><creator>schuller, P.L.</creator><creator>froeling, P.G.A.M.</creator><creator>bruijns, E.</creator><general>Elsevier Ltd</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19820101</creationdate><title>No volatile n-nitrosamines detected in blood and urine from patients ingesting daily large amounts of ammonium nitrate</title><author>ellen, G. ; schuller, P.L. ; froeling, P.G.A.M. ; bruijns, E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c384t-b09fce9ba2044bc628e7656b8c205934896e812a2fa4a446c0f96b4a6440b44f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1982</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Female</topic><topic>food contamination</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Nitrates - administration & dosage</topic><topic>Nitrates - metabolism</topic><topic>Nitrosamines - blood</topic><topic>Nitrosamines - isolation & purification</topic><topic>Nitrosamines - urine</topic><topic>Volatilization</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ellen, G.</creatorcontrib><creatorcontrib>schuller, P.L.</creatorcontrib><creatorcontrib>froeling, P.G.A.M.</creatorcontrib><creatorcontrib>bruijns, E.</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Food and chemical toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ellen, G.</au><au>schuller, P.L.</au><au>froeling, P.G.A.M.</au><au>bruijns, E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>No volatile n-nitrosamines detected in blood and urine from patients ingesting daily large amounts of ammonium nitrate</atitle><jtitle>Food and chemical toxicology</jtitle><addtitle>Food Chem Toxicol</addtitle><date>1982-01-01</date><risdate>1982</risdate><volume>20</volume><issue>6</issue><spage>879</spage><epage>882</epage><pages>879-882</pages><issn>0278-6915</issn><eissn>1873-6351</eissn><abstract>Whole blood and urine from 23 patients ingesting ammonium nitrate daily in amounts varying from 2.5–9 g were analysed for volatile
N-nitrosamines. By contrast with reports in the literature
N-nitrosodimethylamine and
N-nitrosodiethylamine were not found in blood (limit of detection 0.1 μg/kg) but a trace of
N-nitrosopyrrolidine was found in the blood of one subject. Small amounts of
N-nitrosomorpholine in some blood samples and in one blank were believed to be formed during the analysis since morpholine had been added to the samples to indicate artefactual nitrosamine formation. Traces of
N-nitrosodimethylamine (0.1 μg/kg) were found in six of the 23 urine samples.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>6891671</pmid><doi>10.1016/S0015-6264(82)80221-6</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0278-6915 |
| ispartof | Food and chemical toxicology, 1982-01, Vol.20 (6), p.879-882 |
| issn | 0278-6915 1873-6351 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_80287308 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adolescent Adult Female food contamination Humans Male Middle Aged Nitrates - administration & dosage Nitrates - metabolism Nitrosamines - blood Nitrosamines - isolation & purification Nitrosamines - urine Volatilization |
| title | No volatile n-nitrosamines detected in blood and urine from patients ingesting daily large amounts of ammonium nitrate |
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