Characterization of Tachykinin Receptors in Urinary Bladder from Guinea Pig

The contractile responses to substance P (SP), neurokinin A (NKA), Tyr°-neurokinin B (Tyr-NKB), senktide (NK3 receptor selective agonist) and SP methyl ester (SPOMe, NK1 receptor selective agonist) were investigated in detrusor strips from guinea pigs. Except for senktide, all drugs induced a concen...

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Veröffentlicht in:	Japanese Journal of Pharmacology 1990, Vol.54(2), pp.241-243
Hauptverfasser:	SHINKAI, Michiko, TAKAYANAGI, Issei
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Dose-Response Relationship, Drug Female Fundamental and applied biological sciences. Psychology Guinea Pigs Muscle Contraction - drug effects Muscle Contraction - physiology Neurokinin A - pharmacology Neurokinin B - pharmacology Peptide Fragments - pharmacology Receptors, Neurotransmitter - analysis Receptors, Neurotransmitter - drug effects Receptors, Tachykinin Substance P - analogs & derivatives Substance P - pharmacology Urinary Bladder - chemistry Urinary Bladder - drug effects Urinary Bladder - physiology Vertebrates: urinary system
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Zusammenfassung:	The contractile responses to substance P (SP), neurokinin A (NKA), Tyr°-neurokinin B (Tyr-NKB), senktide (NK3 receptor selective agonist) and SP methyl ester (SPOMe, NK1 receptor selective agonist) were investigated in detrusor strips from guinea pigs. Except for senktide, all drugs induced a concentration-related contraction with the following rank order of potency: SPOMe>SP>NKA≧ Tyr-NKB. After desensitization of NK1 receptors with SPOMe, the rank order of potency was NKA≧Tyr-NKB>SP>SPOMe. Both NK1 and NK2 receptors exist in the detrusor strip from guinea pigs.
ISSN:	0021-5198 1347-3506
DOI:	10.1254/jjp.54.241