Effect of an oral Angiotensin I-Converting Enzyme Inhibitor on Blood Pressure and Renin-Angiotensin-Aldosterone System before and after Nephrectomy in two Cases with acute Renovascular Hypertension
Nephrectomy was performed for two cases with acute renovascular hypertension due to clamp injury (Case 1) and blunt lumbar trauma (Case 2), and it was followed by normal plasma renin activity (PRA) and normotension. Changes of blood pressure, pulserate, PRA, plasma aldosterone concentration (PAC) we...
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| Veröffentlicht in: | Nihon Jinzo Gakkai shi 1982/09/25, Vol.24(9), pp.1029-1039 |
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| container_issue | 9 |
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| container_title | Nihon Jinzo Gakkai shi |
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| creator | Irabu, Noritsugu Nakamura, Kazuyuki Morohashi, Yoshio Murakami, Shino Kawamura, Kenji |
| description | Nephrectomy was performed for two cases with acute renovascular hypertension due to clamp injury (Case 1) and blunt lumbar trauma (Case 2), and it was followed by normal plasma renin activity (PRA) and normotension. Changes of blood pressure, pulserate, PRA, plasma aldosterone concentration (PAC) were observed by oral administration of Captopril (12.5mg) before and after nephrectomy. In pre-nephrectomy stage, blood pressure lowered remarkably, PRA increased, and PAC temporarily increased during observation in two cases, Pulse rate was ucchanged. In postnephrectomy stage, blood pressure lowered slightly, PRA increased, and PAC decreased in both cases. Pulse rate was unchanged. Accordingly, it is possible that temporary increase of PAC by oral administration of Captopril before nephrectomy depends on production of bradykinin and prostaglandins. |
| doi_str_mv | 10.14842/jpnjnephrol1959.24.1029 |
| format | Article |
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Changes of blood pressure, pulserate, PRA, plasma aldosterone concentration (PAC) were observed by oral administration of Captopril (12.5mg) before and after nephrectomy. In pre-nephrectomy stage, blood pressure lowered remarkably, PRA increased, and PAC temporarily increased during observation in two cases, Pulse rate was ucchanged. In postnephrectomy stage, blood pressure lowered slightly, PRA increased, and PAC decreased in both cases. Pulse rate was unchanged. 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Changes of blood pressure, pulserate, PRA, plasma aldosterone concentration (PAC) were observed by oral administration of Captopril (12.5mg) before and after nephrectomy. In pre-nephrectomy stage, blood pressure lowered remarkably, PRA increased, and PAC temporarily increased during observation in two cases, Pulse rate was ucchanged. In postnephrectomy stage, blood pressure lowered slightly, PRA increased, and PAC decreased in both cases. Pulse rate was unchanged. Accordingly, it is possible that temporary increase of PAC by oral administration of Captopril before nephrectomy depends on production of bradykinin and prostaglandins.</abstract><cop>Japan</cop><pub>Japanese Society of Nephrology</pub><pmid>6298493</pmid><doi>10.14842/jpnjnephrol1959.24.1029</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0385-2385 |
| ispartof | The Japanese Journal of Nephrology, 1982/09/25, Vol.24(9), pp.1029-1039 |
| issn | 0385-2385 1884-0728 |
| language | jpn |
| recordid | cdi_proquest_miscellaneous_80285107 |
| source | J-STAGE Free; MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Administration, Oral Adult Angiotensin-Converting Enzyme Inhibitors Blood Pressure - drug effects Captopril - administration & dosage Captopril - pharmacology Female Humans Hypertension, Renal - physiopathology Hypertension, Renovascular - physiopathology Hypertension, Renovascular - surgery Male Nephrectomy Proline - analogs & derivatives Renin-Angiotensin System - drug effects |
| title | Effect of an oral Angiotensin I-Converting Enzyme Inhibitor on Blood Pressure and Renin-Angiotensin-Aldosterone System before and after Nephrectomy in two Cases with acute Renovascular Hypertension |
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