Studies on the mechanism of action of 2-β- d-ribofuranosylthiazole-4-carboxamide (NSC 286193)-II : Relationship between dose level and biochemical effects in P388 leukemia in vivo

Administration of the novel thiazole C-nucleoside, 2-β- d-ribofuranosylthiazole-4-carboxamide (NSC 286193), to BDF 1 mice bearing subcutaneous implants of P388 leukemia provoked a sharp depression in the concentration of intratumoral guanine nucleotides and a correspondingly large expansion of the I...

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Veröffentlicht in:	Biochemical pharmacology 1982-12, Vol.31 (23), p.3839-3845
Hauptverfasser:	Jayaram, Hiremagalur N., Smith, Antoinette L., Glazer, Robert I., Johns, David G., Cooney, David A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - metabolism Antineoplastic Agents - pharmacology Guanosine - pharmacology Hypoxanthines - metabolism IMP Dehydrogenase - antagonists & inhibitors Kinetics Leukemia P388 - metabolism Leukemia, Experimental - metabolism Mice Niacinamide - pharmacology Nucleic Acids - biosynthesis Ribavirin - analogs & derivatives Ribavirin - metabolism Ribavirin - pharmacology Ribonucleosides - pharmacology Time Factors
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