Dosage prescribing and plasma oxipurinol levels in patients receiving allopurinol therapy
This study examined dosage prescribing patterns and steady-state oxipurinol plasma concentrations in 66 patients receiving chronic allopurinol therapy. Most patients (65%) were taking 300 mg allopurinol daily, although renal impairment was common. Using published guidelines, it was estimated that 35...
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| Veröffentlicht in: | European journal of clinical pharmacology 1990-01, Vol.39 (4), p.419-421 |
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| container_title | European journal of clinical pharmacology |
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| creator | PETERSON, G. M BOYLE, R. R FRANCIS, H. W OLIVER, N. W. J PATERSON, J VON WITT, R. J TAYLOR, G. R |
| description | This study examined dosage prescribing patterns and steady-state oxipurinol plasma concentrations in 66 patients receiving chronic allopurinol therapy. Most patients (65%) were taking 300 mg allopurinol daily, although renal impairment was common. Using published guidelines, it was estimated that 35% of patients were receiving excessive dosages of allopurinol. Consequently, the plasma oxipurinol concentrations were often very high (mean (SD) was 156 (109) mumol.l-1). Accumulation of oxipurinol was inversely related to renal function. Plasma concentrations of oxipurinol and urate were not significantly related. However, most patients with oxipurinol concentrations of up to 100 mumol.l-1 had urate concentrations within the normal reference range. |
| doi_str_mv | 10.1007/BF00315424 |
| format | Article |
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M ; BOYLE, R. R ; FRANCIS, H. W ; OLIVER, N. W. J ; PATERSON, J ; VON WITT, R. J ; TAYLOR, G. R</creator><creatorcontrib>PETERSON, G. M ; BOYLE, R. R ; FRANCIS, H. W ; OLIVER, N. W. J ; PATERSON, J ; VON WITT, R. J ; TAYLOR, G. R</creatorcontrib><description>This study examined dosage prescribing patterns and steady-state oxipurinol plasma concentrations in 66 patients receiving chronic allopurinol therapy. Most patients (65%) were taking 300 mg allopurinol daily, although renal impairment was common. Using published guidelines, it was estimated that 35% of patients were receiving excessive dosages of allopurinol. Consequently, the plasma oxipurinol concentrations were often very high (mean (SD) was 156 (109) mumol.l-1). Accumulation of oxipurinol was inversely related to renal function. Plasma concentrations of oxipurinol and urate were not significantly related. However, most patients with oxipurinol concentrations of up to 100 mumol.l-1 had urate concentrations within the normal reference range.</description><identifier>ISSN: 0031-6970</identifier><identifier>EISSN: 1432-1041</identifier><identifier>DOI: 10.1007/BF00315424</identifier><identifier>PMID: 2076730</identifier><language>eng</language><publisher>Heidelberg: Springer</publisher><subject>Aged ; Aged, 80 and over ; Allopurinol - administration & dosage ; Allopurinol - therapeutic use ; Biological and medical sciences ; Drug toxicity and drugs side effects treatment ; Female ; Humans ; Male ; Medical sciences ; Middle Aged ; Oxypurinol - blood ; Pharmacology. 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M</creatorcontrib><creatorcontrib>BOYLE, R. R</creatorcontrib><creatorcontrib>FRANCIS, H. W</creatorcontrib><creatorcontrib>OLIVER, N. W. J</creatorcontrib><creatorcontrib>PATERSON, J</creatorcontrib><creatorcontrib>VON WITT, R. J</creatorcontrib><creatorcontrib>TAYLOR, G. R</creatorcontrib><title>Dosage prescribing and plasma oxipurinol levels in patients receiving allopurinol therapy</title><title>European journal of clinical pharmacology</title><addtitle>Eur J Clin Pharmacol</addtitle><description>This study examined dosage prescribing patterns and steady-state oxipurinol plasma concentrations in 66 patients receiving chronic allopurinol therapy. Most patients (65%) were taking 300 mg allopurinol daily, although renal impairment was common. Using published guidelines, it was estimated that 35% of patients were receiving excessive dosages of allopurinol. Consequently, the plasma oxipurinol concentrations were often very high (mean (SD) was 156 (109) mumol.l-1). Accumulation of oxipurinol was inversely related to renal function. Plasma concentrations of oxipurinol and urate were not significantly related. However, most patients with oxipurinol concentrations of up to 100 mumol.l-1 had urate concentrations within the normal reference range.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Allopurinol - administration & dosage</subject><subject>Allopurinol - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Oxypurinol - blood</subject><subject>Pharmacology. 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R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dosage prescribing and plasma oxipurinol levels in patients receiving allopurinol therapy</atitle><jtitle>European journal of clinical pharmacology</jtitle><addtitle>Eur J Clin Pharmacol</addtitle><date>1990-01-01</date><risdate>1990</risdate><volume>39</volume><issue>4</issue><spage>419</spage><epage>421</epage><pages>419-421</pages><issn>0031-6970</issn><eissn>1432-1041</eissn><abstract>This study examined dosage prescribing patterns and steady-state oxipurinol plasma concentrations in 66 patients receiving chronic allopurinol therapy. Most patients (65%) were taking 300 mg allopurinol daily, although renal impairment was common. Using published guidelines, it was estimated that 35% of patients were receiving excessive dosages of allopurinol. Consequently, the plasma oxipurinol concentrations were often very high (mean (SD) was 156 (109) mumol.l-1). Accumulation of oxipurinol was inversely related to renal function. Plasma concentrations of oxipurinol and urate were not significantly related. However, most patients with oxipurinol concentrations of up to 100 mumol.l-1 had urate concentrations within the normal reference range.</abstract><cop>Heidelberg</cop><cop>Berlin</cop><pub>Springer</pub><pmid>2076730</pmid><doi>10.1007/BF00315424</doi><tpages>3</tpages></addata></record> |
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| ispartof | European journal of clinical pharmacology, 1990-01, Vol.39 (4), p.419-421 |
| issn | 0031-6970 1432-1041 |
| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Aged Aged, 80 and over Allopurinol - administration & dosage Allopurinol - therapeutic use Biological and medical sciences Drug toxicity and drugs side effects treatment Female Humans Male Medical sciences Middle Aged Oxypurinol - blood Pharmacology. Drug treatments Time Factors Toxicity: urogenital system |
| title | Dosage prescribing and plasma oxipurinol levels in patients receiving allopurinol therapy |
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