Influence of Pyridoxal-5′-Phosphate on Temperature Relationship of Aspartate Aminotransferase and Alanine Aminotransferase

The influence of pyridoxal-5′-phosphate on the temperature relationship of aspartate aminotransferase and alanine aminotransferase has been determined. On varying the reaction temperature from 25° to 45° both enzymes showed small but significant deviations from a linear Arrhenius relationship. Suppl...

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Veröffentlicht in:	Annals of clinical biochemistry 1982-11, Vol.19 (6), p.426-430
Hauptverfasser:	Hafkenscheid, J C M, Van Der Ven-Jongekrijg, J, De Boo, TH
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine Transaminase - blood Aspartate Aminotransferases - blood Humans Kinetics Pyridoxal Phosphate - pharmacology Temperature Thermodynamics
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container_title	Annals of clinical biochemistry
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creator	Hafkenscheid, J C M Van Der Ven-Jongekrijg, J De Boo, TH
description	The influence of pyridoxal-5′-phosphate on the temperature relationship of aspartate aminotransferase and alanine aminotransferase has been determined. On varying the reaction temperature from 25° to 45° both enzymes showed small but significant deviations from a linear Arrhenius relationship. Supplementation with pyridoxal-5′-phosphate in general enhanced the catalytic activity to the same degree over the entire temperature range. Our results corroborate the findings of Rej but not those of Jung et al.
doi_str_mv	10.1177/000456328201900607
format	Article
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On varying the reaction temperature from 25° to 45° both enzymes showed small but significant deviations from a linear Arrhenius relationship. Supplementation with pyridoxal-5′-phosphate in general enhanced the catalytic activity to the same degree over the entire temperature range. Our results corroborate the findings of Rej but not those of Jung et al.</description><identifier>ISSN: 0004-5632</identifier><identifier>EISSN: 1758-1001</identifier><identifier>DOI: 10.1177/000456328201900607</identifier><identifier>PMID: 7159011</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Alanine Transaminase - blood ; Aspartate Aminotransferases - blood ; Humans ; Kinetics ; Pyridoxal Phosphate - pharmacology ; Temperature ; Thermodynamics</subject><ispartof>Annals of clinical biochemistry, 1982-11, Vol.19 (6), p.426-430</ispartof><rights>1982 Association for Clinical Biochemistry</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c338t-707056498842cc26871ad3b84ba41322a3b612640ee2f6ec1904604e6097c0f3</citedby><cites>FETCH-LOGICAL-c338t-707056498842cc26871ad3b84ba41322a3b612640ee2f6ec1904604e6097c0f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7159011$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hafkenscheid, J C M</creatorcontrib><creatorcontrib>Van Der Ven-Jongekrijg, J</creatorcontrib><creatorcontrib>De Boo, TH</creatorcontrib><title>Influence of Pyridoxal-5′-Phosphate on Temperature Relationship of Aspartate Aminotransferase and Alanine Aminotransferase</title><title>Annals of clinical biochemistry</title><addtitle>Ann Clin Biochem</addtitle><description>The influence of pyridoxal-5′-phosphate on the temperature relationship of aspartate aminotransferase and alanine aminotransferase has been determined. On varying the reaction temperature from 25° to 45° both enzymes showed small but significant deviations from a linear Arrhenius relationship. Supplementation with pyridoxal-5′-phosphate in general enhanced the catalytic activity to the same degree over the entire temperature range. Our results corroborate the findings of Rej but not those of Jung et al.</description><subject>Alanine Transaminase - blood</subject><subject>Aspartate Aminotransferases - blood</subject><subject>Humans</subject><subject>Kinetics</subject><subject>Pyridoxal Phosphate - pharmacology</subject><subject>Temperature</subject><subject>Thermodynamics</subject><issn>0004-5632</issn><issn>1758-1001</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1982</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kN1KwzAYhoMoc05vQBB65Fndl7RNssMx_BkMHLLzkrZfXUeb1KQFBx54TV6SV2LKhieCRyG8z_uSPIRcU7ijVIgpAMQJj5hkQGcAHMQJGVORyJAC0FMyHoBwIM7JhXM7f2UCYERGgiYzoHRMPpa6rHvUOQamDNZ7WxXmXdVh8v35Fa63xrVb1flMBxtsWrSq6y0GL1irrjLabat26M1dq2w3gPOm0qazSrvSww4DpYtgXitd6b_hJTkrVe3w6nhOyObhfrN4ClfPj8vFfBXmUSS7UICAhMczKWOW54xLQVURZTLOVEwjxlSUccp4DIis5Jh7FzGHGDnMRA5lNCG3h9nWmrceXZc2lcux9q9C07tUApORN-ZBdgBza5yzWKatrRpl9ymFdDCe_jXuSzfH9T5rsPitHBX7fHrInXrFdGd6q_1f_1v8AcCHilc</recordid><startdate>198211</startdate><enddate>198211</enddate><creator>Hafkenscheid, J C M</creator><creator>Van Der Ven-Jongekrijg, J</creator><creator>De Boo, TH</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198211</creationdate><title>Influence of Pyridoxal-5′-Phosphate on Temperature Relationship of Aspartate Aminotransferase and Alanine Aminotransferase</title><author>Hafkenscheid, J C M ; Van Der Ven-Jongekrijg, J ; De Boo, TH</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c338t-707056498842cc26871ad3b84ba41322a3b612640ee2f6ec1904604e6097c0f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1982</creationdate><topic>Alanine Transaminase - blood</topic><topic>Aspartate Aminotransferases - blood</topic><topic>Humans</topic><topic>Kinetics</topic><topic>Pyridoxal Phosphate - pharmacology</topic><topic>Temperature</topic><topic>Thermodynamics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hafkenscheid, J C M</creatorcontrib><creatorcontrib>Van Der Ven-Jongekrijg, J</creatorcontrib><creatorcontrib>De Boo, TH</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of clinical biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hafkenscheid, J C M</au><au>Van Der Ven-Jongekrijg, J</au><au>De Boo, TH</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of Pyridoxal-5′-Phosphate on Temperature Relationship of Aspartate Aminotransferase and Alanine Aminotransferase</atitle><jtitle>Annals of clinical biochemistry</jtitle><addtitle>Ann Clin Biochem</addtitle><date>1982-11</date><risdate>1982</risdate><volume>19</volume><issue>6</issue><spage>426</spage><epage>430</epage><pages>426-430</pages><issn>0004-5632</issn><eissn>1758-1001</eissn><abstract>The influence of pyridoxal-5′-phosphate on the temperature relationship of aspartate aminotransferase and alanine aminotransferase has been determined. On varying the reaction temperature from 25° to 45° both enzymes showed small but significant deviations from a linear Arrhenius relationship. Supplementation with pyridoxal-5′-phosphate in general enhanced the catalytic activity to the same degree over the entire temperature range. Our results corroborate the findings of Rej but not those of Jung et al.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>7159011</pmid><doi>10.1177/000456328201900607</doi><tpages>5</tpages></addata></record>
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source	MEDLINE; Alma/SFX Local Collection
subjects	Alanine Transaminase - blood Aspartate Aminotransferases - blood Humans Kinetics Pyridoxal Phosphate - pharmacology Temperature Thermodynamics
title	Influence of Pyridoxal-5′-Phosphate on Temperature Relationship of Aspartate Aminotransferase and Alanine Aminotransferase
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