Anti-substance P anti-idiotypic antibodies modulate the secretory process in the rat parotid gland in vitro

Anti-idiotypic antibodies (anti-Id) obtained in rabbits in response to immunization with polyclonal anti-substance P antibodies (anti-SP) were shown to bind specifically and with high affinity to membranes from rat parotid gland cells. Whereas substace P (SP) was unable to displace anti-Id from memb...

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Veröffentlicht in:	European journal of pharmacology 1990-10, Vol.187 (3), p.357-367
Hauptverfasser:	Maillet, Sylvie, Imhoff, Viviane, Rossignol, Bernard, Grassi, Jacques, Pradelles, Philippe, Couraud, Jean-Yves
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-idiotypic antibodies Antibodies, Anti-Idiotypic - isolation & purification Antibodies, Anti-Idiotypic - metabolism Antibodies, Monoclonal Biological and medical sciences Cyclic AMP - metabolism Fundamental and applied biological sciences. Psychology Immunoglobulins - isolation & purification In Vitro Techniques Iodine Radioisotopes Isoproterenol - pharmacology Male Mouth. Exocrine and endocrine salivary glands. Teeth. Esophagus Parotid gland (rat) Parotid Gland - immunology Parotid Gland - metabolism Protein secretion Rats Rats, Inbred Strains Receptors, Neurokinin-1 Receptors, Neurotransmitter - immunology Receptors, Neurotransmitter - metabolism Substance P - immunology Substance P receptors Vertebrates: digestive system
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