Electrical analysis of fresh, excised human skin : a comparison with frozen skin
Samples of human allograft skin prepared without freezing ("fresh skin") were found to have electrical and sodium ion transport properties which differed only slightly from those of skin which had been similarly treated but stored frozen ("frozen skin"). The fresh skin samples we...
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| Veröffentlicht in: | Pharmaceutical research 1990-11, Vol.7 (11), p.1141-1146 |
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| creator | KASTING, G. B BOWMAN, L. A |
| description | Samples of human allograft skin prepared without freezing ("fresh skin") were found to have electrical and sodium ion transport properties which differed only slightly from those of skin which had been similarly treated but stored frozen ("frozen skin"). The fresh skin samples were less permeable to sodium ions during passive diffusion and less conductive than frozen skin at low current levels. They were more permselective for sodium versus chloride during constant-current iontophoresis and showed slightly more asymmetry in their current-voltage properties. Overall, the electrical behavior of the two tissues was similar enough to support the use of frozen tissue in iontophoresis studies. However, caution should be exercised when considering the use of frozen skin for applications, such as those based on electroosmosis, where the observed differences could have a major impact on the results. |
| doi_str_mv | 10.1023/A:1015928225089 |
| format | Article |
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B ; BOWMAN, L. A</creator><creatorcontrib>KASTING, G. B ; BOWMAN, L. A</creatorcontrib><description>Samples of human allograft skin prepared without freezing ("fresh skin") were found to have electrical and sodium ion transport properties which differed only slightly from those of skin which had been similarly treated but stored frozen ("frozen skin"). The fresh skin samples were less permeable to sodium ions during passive diffusion and less conductive than frozen skin at low current levels. They were more permselective for sodium versus chloride during constant-current iontophoresis and showed slightly more asymmetry in their current-voltage properties. Overall, the electrical behavior of the two tissues was similar enough to support the use of frozen tissue in iontophoresis studies. However, caution should be exercised when considering the use of frozen skin for applications, such as those based on electroosmosis, where the observed differences could have a major impact on the results.</description><identifier>ISSN: 0724-8741</identifier><identifier>EISSN: 1573-904X</identifier><identifier>DOI: 10.1023/A:1015928225089</identifier><identifier>PMID: 2293212</identifier><identifier>CODEN: PHREEB</identifier><language>eng</language><publisher>New York, NY: Springer</publisher><subject>Biological and medical sciences ; Diffusion ; Electrophysiology ; Freezing ; General pharmacology ; Humans ; In Vitro Techniques ; Iontophoresis ; Male ; Medical sciences ; Pharmaceutical technology. Pharmaceutical industry ; Pharmacology. 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B</creatorcontrib><creatorcontrib>BOWMAN, L. A</creatorcontrib><title>Electrical analysis of fresh, excised human skin : a comparison with frozen skin</title><title>Pharmaceutical research</title><addtitle>Pharm Res</addtitle><description>Samples of human allograft skin prepared without freezing ("fresh skin") were found to have electrical and sodium ion transport properties which differed only slightly from those of skin which had been similarly treated but stored frozen ("frozen skin"). The fresh skin samples were less permeable to sodium ions during passive diffusion and less conductive than frozen skin at low current levels. They were more permselective for sodium versus chloride during constant-current iontophoresis and showed slightly more asymmetry in their current-voltage properties. Overall, the electrical behavior of the two tissues was similar enough to support the use of frozen tissue in iontophoresis studies. However, caution should be exercised when considering the use of frozen skin for applications, such as those based on electroosmosis, where the observed differences could have a major impact on the results.</description><subject>Biological and medical sciences</subject><subject>Diffusion</subject><subject>Electrophysiology</subject><subject>Freezing</subject><subject>General pharmacology</subject><subject>Humans</subject><subject>In Vitro Techniques</subject><subject>Iontophoresis</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><subject>Skin Absorption</subject><subject>Skin Physiological Phenomena</subject><subject>Sodium - pharmacokinetics</subject><subject>Sodium Radioisotopes</subject><issn>0724-8741</issn><issn>1573-904X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kEtLAzEUhYMotVbXroRsdOVonk3irpT6gIIuFNwNmcwNjc6jTmbQ-usNdHB1F-fjcL-D0DklN5Qwfru4o4RKwzRjkmhzgKZUKp4ZIt4P0ZQoJjKtBD1GJzF-EEI0NWKCJowZziibopdVBa7vgrMVto2tdjFE3HrsO4ibaww_LkQo8WaobYPjZ2jwHbbYtfXWdiG2Df4O_SbR7S_s81N05G0V4Wy8M_R2v3pdPmbr54en5WKdufRrn2nOJFjGQcuCKCm89dJ6xUsBymhV0KSl55Z6ktxKJ0tSQiGk9kYyKLnjM3S179127dcAsc_rEB1UlW2gHWKuCVNKapXAixEcihrKfNuF2na7fJwg5ZdjbmNawXe2Sc7_WNprLiSn_A-kkGoN</recordid><startdate>19901101</startdate><enddate>19901101</enddate><creator>KASTING, G. B</creator><creator>BOWMAN, L. 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Pharmaceutical industry</topic><topic>Pharmacology. Drug treatments</topic><topic>Skin Absorption</topic><topic>Skin Physiological Phenomena</topic><topic>Sodium - pharmacokinetics</topic><topic>Sodium Radioisotopes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KASTING, G. B</creatorcontrib><creatorcontrib>BOWMAN, L. A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Pharmaceutical research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KASTING, G. B</au><au>BOWMAN, L. A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Electrical analysis of fresh, excised human skin : a comparison with frozen skin</atitle><jtitle>Pharmaceutical research</jtitle><addtitle>Pharm Res</addtitle><date>1990-11-01</date><risdate>1990</risdate><volume>7</volume><issue>11</issue><spage>1141</spage><epage>1146</epage><pages>1141-1146</pages><issn>0724-8741</issn><eissn>1573-904X</eissn><coden>PHREEB</coden><abstract>Samples of human allograft skin prepared without freezing ("fresh skin") were found to have electrical and sodium ion transport properties which differed only slightly from those of skin which had been similarly treated but stored frozen ("frozen skin"). The fresh skin samples were less permeable to sodium ions during passive diffusion and less conductive than frozen skin at low current levels. They were more permselective for sodium versus chloride during constant-current iontophoresis and showed slightly more asymmetry in their current-voltage properties. Overall, the electrical behavior of the two tissues was similar enough to support the use of frozen tissue in iontophoresis studies. However, caution should be exercised when considering the use of frozen skin for applications, such as those based on electroosmosis, where the observed differences could have a major impact on the results.</abstract><cop>New York, NY</cop><pub>Springer</pub><pmid>2293212</pmid><doi>10.1023/A:1015928225089</doi><tpages>6</tpages></addata></record> |
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| ispartof | Pharmaceutical research, 1990-11, Vol.7 (11), p.1141-1146 |
| issn | 0724-8741 1573-904X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_80277587 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Biological and medical sciences Diffusion Electrophysiology Freezing General pharmacology Humans In Vitro Techniques Iontophoresis Male Medical sciences Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Skin Absorption Skin Physiological Phenomena Sodium - pharmacokinetics Sodium Radioisotopes |
| title | Electrical analysis of fresh, excised human skin : a comparison with frozen skin |
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