Analysis of Epstein-Barr viral genomes in lymphoid malignancy using Southern blotting, polymerase chain reaction and in situ hybridization

109 malignant lymphomas were surveyed by Southern blot analysis and polymerase chain reaction (PCR) for Epstein-Barr virus (EBV) DNA and compared with 16 examples of non-neoplastic lymphadenopathy and 4 normal thymuses. In specimens positive by the method of Southern and PCR, in situ hybridization s...

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Veröffentlicht in:	Virchows Archiv. B, Cell pathology Cell pathology, 1990, Vol.59 (6), p.383-390
Hauptverfasser:	Ohshima, K, Kikuchi, M, Eguchi, F, Masuda, Y, Sumiyoshi, Y, Mohtai, H, Takeshita, M, Kimura, N
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence DNA Probes DNA, Viral - analysis Gene Rearrangement Gene Rearrangement, T-Lymphocyte Herpesvirus 4, Human - genetics Hodgkin Disease - microbiology Hodgkin Disease - pathology Humans Immunoglobulin Heavy Chains - genetics Lymphadenitis - microbiology Lymphoma - microbiology Lymphoma, B-Cell - microbiology Lymphoma, B-Cell - pathology Lymphoma, T-Cell - microbiology Lymphoma, T-Cell - pathology Molecular Sequence Data Nucleic Acid Hybridization Polymerase Chain Reaction Thymus Gland - microbiology
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