The accumulation of oxidized isoforms of chicken triosephosphate isomerase during aging and development

Triosephosphate isomerase (TPI) from mammals undergoes two specific deamidations (Asn-15 and Asn-71) which destabilize the isologous dimer and lead to the degradation of the protein. In aging cells and tissues, the deamidated isoforms accumulate apparently due to age-related changes in protein turno...

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Veröffentlicht in:	Mechanisms of ageing and development 1990-11, Vol.56 (2), p.179-186
Hauptverfasser:	Noelle Gracy, K., Tang, C.Y., Ümit Yüksel, K., Gracy, Robert W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Aging - metabolism Amino Acid Sequence Animals Chick Embryo Chicken Chickens Development Isoenzymes - metabolism Isozymes Oxidation Oxidation-Reduction Tissue Distribution Triose-Phosphate Isomerase - chemistry Triose-Phosphate Isomerase - metabolism Triosephosphate isomerase
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