Reduction of delayed neuronal death by inhibition of protein synthesis
Brief forebrain ischemia in rodents causes delayed neuronal death selectively in the CA1 pyramidal cells of hippocampus. Treatment with a reversible protein synthesis inhibitor, anisomycin, significantly reduced the occurrence of delayed neuronal death in the Mongolian gerbil. This result indicates...
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| Veröffentlicht in: | Neuroscience letters 1990-11, Vol.120 (1), p.117-119 |
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| container_end_page | 119 |
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| container_issue | 1 |
| container_start_page | 117 |
| container_title | Neuroscience letters |
| container_volume | 120 |
| creator | Shigeno, Taku Yamasaki, Yasundo Kato, Gunshiro Kusaka, Kazuyo Mima, Tatsuo Takakura, Kintomo Graham, David I. Furukawa, Shoei |
| description | Brief forebrain ischemia in rodents causes delayed neuronal death selectively in the CA1 pyramidal cells of hippocampus. Treatment with a reversible protein synthesis inhibitor, anisomycin, significantly reduced the occurrence of delayed neuronal death in the Mongolian gerbil. This result indicates that de novo synthesis of certain protein(s), collectively termed ‘killer protein’ is required, possibly due to deprivation of nerve growth factor or other trophic factors. |
| doi_str_mv | 10.1016/0304-3940(90)90182-9 |
| format | Article |
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Psychology ; Gerbillinae ; Hippocampus ; Hippocampus - drug effects ; Hippocampus - pathology ; Ischemic Attack, Transient - pathology ; Killer protein ; Meriones unguiculatus ; Nerve growth factor ; Neurons - drug effects ; Neurons - pathology ; Protein Synthesis Inhibitors ; Pyramidal Tracts - drug effects ; Pyramidal Tracts - pathology ; Reference Values ; Vertebrates: nervous system and sense organs</subject><ispartof>Neuroscience letters, 1990-11, Vol.120 (1), p.117-119</ispartof><rights>1990</rights><rights>1991 INIST-CNRS</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c447t-a098ea5ccf16c42751ec564e8d0a8444c75942f8d36a098171818afb95cd93a13</citedby><cites>FETCH-LOGICAL-c447t-a098ea5ccf16c42751ec564e8d0a8444c75942f8d36a098171818afb95cd93a13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0304394090901829$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19450789$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5169642$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2293081$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shigeno, Taku</creatorcontrib><creatorcontrib>Yamasaki, Yasundo</creatorcontrib><creatorcontrib>Kato, Gunshiro</creatorcontrib><creatorcontrib>Kusaka, Kazuyo</creatorcontrib><creatorcontrib>Mima, Tatsuo</creatorcontrib><creatorcontrib>Takakura, Kintomo</creatorcontrib><creatorcontrib>Graham, David I.</creatorcontrib><creatorcontrib>Furukawa, Shoei</creatorcontrib><title>Reduction of delayed neuronal death by inhibition of protein synthesis</title><title>Neuroscience letters</title><addtitle>Neurosci Lett</addtitle><description>Brief forebrain ischemia in rodents causes delayed neuronal death selectively in the CA1 pyramidal cells of hippocampus. Treatment with a reversible protein synthesis inhibitor, anisomycin, significantly reduced the occurrence of delayed neuronal death in the Mongolian gerbil. This result indicates that de novo synthesis of certain protein(s), collectively termed ‘killer protein’ is required, possibly due to deprivation of nerve growth factor or other trophic factors.</description><subject>Animals</subject><subject>Anisomycin</subject><subject>Anisomycin - pharmacology</subject><subject>Biochemistry and metabolism</subject><subject>Biological and medical sciences</subject><subject>Cell Survival - drug effects</subject><subject>Central nervous system</subject><subject>Cerebral ischemia</subject><subject>Delayed neuronal death</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gerbillinae</subject><subject>Hippocampus</subject><subject>Hippocampus - drug effects</subject><subject>Hippocampus - pathology</subject><subject>Ischemic Attack, Transient - pathology</subject><subject>Killer protein</subject><subject>Meriones unguiculatus</subject><subject>Nerve growth factor</subject><subject>Neurons - drug effects</subject><subject>Neurons - pathology</subject><subject>Protein Synthesis Inhibitors</subject><subject>Pyramidal Tracts - drug effects</subject><subject>Pyramidal Tracts - pathology</subject><subject>Reference Values</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkN9rFDEQgIMo7bX1P7CwD1Xsw9aZbLJJXgQprRUKguhzyCWzXGQv2ya7wv337nLnPVYYGJj55gcfY-8QbhCw_QQNiLoxAj4auDaAmtfmFVuhVrxWRvHXbHVETtlZKb8BQKIUJ-yEc9OAxhW7_0Fh8mMcUjV0VaDe7ShUiaY8JNfPBTduqvWuimkT1_Ef95SHkWKqyi6NGyqxXLA3nesLvT3kc_br_u7n7UP9-P3rt9svj7UXQo21A6PJSe87bL3gSiJ52QrSAZwWQngljeCdDk27oKhQo3bd2kgfTOOwOWcf9nvnD54nKqPdxuKp712iYSpWA1fYcPFfEKUWgELPoNiDPg-lZOrsU45bl3cWwS6e7SLRLhKtWWL2bM08dnnYP623FI5DB7Fz_-rQd8W7vssu-ViOmMTWtILP2PuXMDRCgtLLuc97jma5fyJlW3yk5CnETH60YYgv__sXnkSk4Q</recordid><startdate>19901127</startdate><enddate>19901127</enddate><creator>Shigeno, Taku</creator><creator>Yamasaki, Yasundo</creator><creator>Kato, Gunshiro</creator><creator>Kusaka, Kazuyo</creator><creator>Mima, Tatsuo</creator><creator>Takakura, Kintomo</creator><creator>Graham, David I.</creator><creator>Furukawa, Shoei</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19901127</creationdate><title>Reduction of delayed neuronal death by inhibition of protein synthesis</title><author>Shigeno, Taku ; Yamasaki, Yasundo ; Kato, Gunshiro ; Kusaka, Kazuyo ; Mima, Tatsuo ; Takakura, Kintomo ; Graham, David I. ; Furukawa, Shoei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c447t-a098ea5ccf16c42751ec564e8d0a8444c75942f8d36a098171818afb95cd93a13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Animals</topic><topic>Anisomycin</topic><topic>Anisomycin - pharmacology</topic><topic>Biochemistry and metabolism</topic><topic>Biological and medical sciences</topic><topic>Cell Survival - drug effects</topic><topic>Central nervous system</topic><topic>Cerebral ischemia</topic><topic>Delayed neuronal death</topic><topic>Fundamental and applied biological sciences. 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| identifier | ISSN: 0304-3940 |
| ispartof | Neuroscience letters, 1990-11, Vol.120 (1), p.117-119 |
| issn | 0304-3940 1872-7972 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Anisomycin Anisomycin - pharmacology Biochemistry and metabolism Biological and medical sciences Cell Survival - drug effects Central nervous system Cerebral ischemia Delayed neuronal death Fundamental and applied biological sciences. Psychology Gerbillinae Hippocampus Hippocampus - drug effects Hippocampus - pathology Ischemic Attack, Transient - pathology Killer protein Meriones unguiculatus Nerve growth factor Neurons - drug effects Neurons - pathology Protein Synthesis Inhibitors Pyramidal Tracts - drug effects Pyramidal Tracts - pathology Reference Values Vertebrates: nervous system and sense organs |
| title | Reduction of delayed neuronal death by inhibition of protein synthesis |
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