Detection of free radicals during the cellular metabolism of adriamycin

Experiments were conducted to determine which free radicals are generated during the metabolism of adriamycin (ADM) by canine tracheal epithelial (CTE) cells, guinea pig enterocytes, and rat hepatocytes. The technique employed in this study was spin trapping; the spin trap utilized was 5,5-dimethyl-...

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Veröffentlicht in:	Free radical biology & medicine 1990, Vol.9 (5), p.415-421
Hauptverfasser:	Turner, Marvin J., Everman, David B., Ellington, Sharon P., Fields, Charles E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adriamycin Adriamycin semiquinone free radical Animals Antineoplastic agents Biological and medical sciences Chemotherapy Dogs Doxorubicin - chemistry Doxorubicin - metabolism Drug metabolism Electron Spin Resonance Spectroscopy Free Radicals Guinea Pigs Hydroxides - metabolism Hydroxyl Radical In Vitro Techniques Intestinal Mucosa - metabolism Liver - metabolism Male Medical sciences Pharmacology. Drug treatments Rats Rats, Inbred F344 Spin trapping Superoxide Superoxides - metabolism Trachea - metabolism
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