Antimuscarinic drugs: Traditional and potential new therapeutic agents

Antimuscarinic drugs: Traditional and potential new therapeutic agents

Antimuscarinic drugs, used for centuries by physicians and credited in modern times with several therapeutic virtues, have been losing ground in recent years to other pharmacological classes, mainly because of their poor specificity and consequent repercussions throughout the parasympathetic system....

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Veröffentlicht in:Pharmacological research communications 1982-11, Vol.14 (10), p.923-940
Hauptverfasser: Turbanti, L., Subissi, A., Bramanti, G.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Humans
Parasympatholytics - pharmacology
Parasympatholytics - therapeutic use
Receptors, Muscarinic - drug effects
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container_title Pharmacological research communications
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creator Turbanti, L.
Subissi, A.
Bramanti, G.
description Antimuscarinic drugs, used for centuries by physicians and credited in modern times with several therapeutic virtues, have been losing ground in recent years to other pharmacological classes, mainly because of their poor specificity and consequent repercussions throughout the parasympathetic system. Recent pharmacological data suggest the hypothesis of subclasses of muscarinic receptors. This in turn opens up the possibility of more specific antimuscarinic drugs fashioned for these subclasses. This review is not an attempt to cover all pharmacological aspects of the muscarinic receptor; rather, it is intended to serve as a practical contribution, on the part of industrial reserchers, by suggesting new therapeutic potentialities in some specific areas.
doi_str_mv 10.1016/S0031-6989(82)80057-X
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subjects Animals
Humans
Parasympatholytics - pharmacology
Parasympatholytics - therapeutic use
Receptors, Muscarinic - drug effects
title Antimuscarinic drugs: Traditional and potential new therapeutic agents
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