Host Range Mutants of Vesicular Stomatitis Virus Defective in in vitro RNA Methylation

The viral RNA polymerase of detergent-treated vesicular stomatitis virus normally synthesizes viral mRNAs in vitro that are both guanylylated and methylated to give 5′-terminal 7mGpppAmcaps. We have characterized a virus host range mutant, hr 1, that is totally defective in vitro in the methylation...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1982-12, Vol.79 (24), p.7694-7698
Hauptverfasser:	Horikami, Sandra M., Moyer, Sue A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell lines Cell-Free System Electrophoresis Gels Genes, Viral Host range Messenger RNA Methylation Methyltransferases - genetics Mutation Oligonucleotides Protein Biosynthesis RNA RNA, Messenger - genetics Vesicular stomatitis Indiana virus - genetics Virology Virus Replication Viruses
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