Acetyl-l-carnitine restores the daily pattern of hypothalamic β-endorphin in rats exposed to continuous light
With the aim of evaluating the effect of acetyl-l-carnitine (ALC) on the daily pattern of hypothalamic β-endorphin (β-EP), we studied the effect of chronic treatment with ALC on hypothalamic β-EP contents after suppression of the dark-phase of the light-dark cycle in female rats. We evaluated the hy...
Gespeichert in:
| Veröffentlicht in: | European journal of pharmacology 1990-09, Vol.186 (2), p.177-180 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 180 |
|---|---|
| container_issue | 2 |
| container_start_page | 177 |
| container_title | European journal of pharmacology |
| container_volume | 186 |
| creator | Genazzani, Andrea R. De Ramundo, Biagina M. Criscuolo, Mario De Gaetani, Carmela Ficarra, Guido Genazzani, Alessandro D. Petraglia, Felice Trentini, Gian P. |
| description | With the aim of evaluating the effect of acetyl-l-carnitine (ALC) on the daily pattern of hypothalamic β-endorphin (β-EP), we studied the effect of chronic treatment with ALC on hypothalamic β-EP contents after suppression of the dark-phase of the light-dark cycle in female rats. We evaluated the hypothalamic content of β-EP immunoreactivity every 3 h for 24 h in: (1) female rats treated with ALC for 15 days; (2) female rats treated with ALC for 15 days and exposed to continuous light for 24 h. The concentration of β-EP immunoreactivity in tissue extracts was measured by radioimmunoassay. The results demonstrate that concentrations of β-EP immunoreactivity in the medial basal hypothalamus show a circadian rhythm, with β-EP immunoreactivity levels being higher during the night than during the rest of the day. Exposure to continuous light for 24 h abolished the nocturnal increase in hypothalamic β-EP immunoreactivity. Rats treated with ALC showed a daily pattern in the β-EP content of the medial basal hypothalamus similar to that of control rats. These data emphasize the possible role of ALC in restoring or maintaining the endogenous rhythmicity of central β-EP. |
| doi_str_mv | 10.1016/0014-2999(90)90431-5 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_80264014</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>0014299990904315</els_id><sourcerecordid>15878647</sourcerecordid><originalsourceid>FETCH-LOGICAL-c418t-57dae307ad2df4c0f4393c335378640f701057ff91a174540a10f1f1053e37be3</originalsourceid><addsrcrecordid>eNqFkd9uFCEUxonR1G31DTThRqMXUw8DLMONSdP4L2nSG70mlDk4mFkYgW3c1-qD-Eyy7qbe1YRAwvmdj8P3EfKCwTkDtn4HwETXa63faHirQXDWyUdkxQalO1Csf0xW98hTclrKDwCQupcn5KTvBy17sSLxwmHdzd3cOZtjqCEizVhqahutE9LRhnlHF1sr5kiTp9NuSXWys90ER3_fdRjHlJcpRNpWtrVQ_LWkgiOtiboUm-Q2bQudw_epPiNPvJ0LPj-eZ-Tbxw9fLz93V9efvlxeXHVOsKF2Uo0WOSg79qMXDrzgmjvOJVfDWoBXwEAq7zWzTAkpwDLwzLdLjlzdID8jrw-6S04_t-0_ZhOKw3m2EdswZoC-6TDxX5DJYf-kaqA4gC6nUjJ6s-SwsXlnGJh9HmZvttmbbTSYv3kY2dpeHvW3Nxsc75uOAbT6q2PdFmdnn210ofzT1lyu2bpv3PsDh82124DZFBcwOhxDRlfNmMLDg_wBFdSn6w</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>15878647</pqid></control><display><type>article</type><title>Acetyl-l-carnitine restores the daily pattern of hypothalamic β-endorphin in rats exposed to continuous light</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Genazzani, Andrea R. ; De Ramundo, Biagina M. ; Criscuolo, Mario ; De Gaetani, Carmela ; Ficarra, Guido ; Genazzani, Alessandro D. ; Petraglia, Felice ; Trentini, Gian P.</creator><creatorcontrib>Genazzani, Andrea R. ; De Ramundo, Biagina M. ; Criscuolo, Mario ; De Gaetani, Carmela ; Ficarra, Guido ; Genazzani, Alessandro D. ; Petraglia, Felice ; Trentini, Gian P.</creatorcontrib><description>With the aim of evaluating the effect of acetyl-l-carnitine (ALC) on the daily pattern of hypothalamic β-endorphin (β-EP), we studied the effect of chronic treatment with ALC on hypothalamic β-EP contents after suppression of the dark-phase of the light-dark cycle in female rats. We evaluated the hypothalamic content of β-EP immunoreactivity every 3 h for 24 h in: (1) female rats treated with ALC for 15 days; (2) female rats treated with ALC for 15 days and exposed to continuous light for 24 h. The concentration of β-EP immunoreactivity in tissue extracts was measured by radioimmunoassay. The results demonstrate that concentrations of β-EP immunoreactivity in the medial basal hypothalamus show a circadian rhythm, with β-EP immunoreactivity levels being higher during the night than during the rest of the day. Exposure to continuous light for 24 h abolished the nocturnal increase in hypothalamic β-EP immunoreactivity. Rats treated with ALC showed a daily pattern in the β-EP content of the medial basal hypothalamus similar to that of control rats. These data emphasize the possible role of ALC in restoring or maintaining the endogenous rhythmicity of central β-EP.</description><identifier>ISSN: 0014-2999</identifier><identifier>EISSN: 1879-0712</identifier><identifier>DOI: 10.1016/0014-2999(90)90431-5</identifier><identifier>PMID: 2289524</identifier><identifier>CODEN: EJPHAZ</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Acetyl-l-carnitine ; Acetylcarnitine - pharmacology ; Animals ; beta-Endorphin - metabolism ; Biological and medical sciences ; Circadian rhythm ; Circadian Rhythm - drug effects ; Female ; Fundamental and applied biological sciences. Psychology ; Hormones and neuropeptides. Regulation ; Hypothalamus - drug effects ; Hypothalamus - metabolism ; Hypothalamus-pituitary-gonadal axis ; Hypothalamus. Hypophysis. Epiphysis. Urophysis ; Light ; Radioimmunoassay ; Rats ; Rats, Inbred Strains ; Vertebrates: endocrinology ; β-Endorphin</subject><ispartof>European journal of pharmacology, 1990-09, Vol.186 (2), p.177-180</ispartof><rights>1990</rights><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c418t-57dae307ad2df4c0f4393c335378640f701057ff91a174540a10f1f1053e37be3</citedby><cites>FETCH-LOGICAL-c418t-57dae307ad2df4c0f4393c335378640f701057ff91a174540a10f1f1053e37be3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0014-2999(90)90431-5$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19356162$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2289524$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Genazzani, Andrea R.</creatorcontrib><creatorcontrib>De Ramundo, Biagina M.</creatorcontrib><creatorcontrib>Criscuolo, Mario</creatorcontrib><creatorcontrib>De Gaetani, Carmela</creatorcontrib><creatorcontrib>Ficarra, Guido</creatorcontrib><creatorcontrib>Genazzani, Alessandro D.</creatorcontrib><creatorcontrib>Petraglia, Felice</creatorcontrib><creatorcontrib>Trentini, Gian P.</creatorcontrib><title>Acetyl-l-carnitine restores the daily pattern of hypothalamic β-endorphin in rats exposed to continuous light</title><title>European journal of pharmacology</title><addtitle>Eur J Pharmacol</addtitle><description>With the aim of evaluating the effect of acetyl-l-carnitine (ALC) on the daily pattern of hypothalamic β-endorphin (β-EP), we studied the effect of chronic treatment with ALC on hypothalamic β-EP contents after suppression of the dark-phase of the light-dark cycle in female rats. We evaluated the hypothalamic content of β-EP immunoreactivity every 3 h for 24 h in: (1) female rats treated with ALC for 15 days; (2) female rats treated with ALC for 15 days and exposed to continuous light for 24 h. The concentration of β-EP immunoreactivity in tissue extracts was measured by radioimmunoassay. The results demonstrate that concentrations of β-EP immunoreactivity in the medial basal hypothalamus show a circadian rhythm, with β-EP immunoreactivity levels being higher during the night than during the rest of the day. Exposure to continuous light for 24 h abolished the nocturnal increase in hypothalamic β-EP immunoreactivity. Rats treated with ALC showed a daily pattern in the β-EP content of the medial basal hypothalamus similar to that of control rats. These data emphasize the possible role of ALC in restoring or maintaining the endogenous rhythmicity of central β-EP.</description><subject>Acetyl-l-carnitine</subject><subject>Acetylcarnitine - pharmacology</subject><subject>Animals</subject><subject>beta-Endorphin - metabolism</subject><subject>Biological and medical sciences</subject><subject>Circadian rhythm</subject><subject>Circadian Rhythm - drug effects</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hormones and neuropeptides. Regulation</subject><subject>Hypothalamus - drug effects</subject><subject>Hypothalamus - metabolism</subject><subject>Hypothalamus-pituitary-gonadal axis</subject><subject>Hypothalamus. Hypophysis. Epiphysis. Urophysis</subject><subject>Light</subject><subject>Radioimmunoassay</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Vertebrates: endocrinology</subject><subject>β-Endorphin</subject><issn>0014-2999</issn><issn>1879-0712</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkd9uFCEUxonR1G31DTThRqMXUw8DLMONSdP4L2nSG70mlDk4mFkYgW3c1-qD-Eyy7qbe1YRAwvmdj8P3EfKCwTkDtn4HwETXa63faHirQXDWyUdkxQalO1Csf0xW98hTclrKDwCQupcn5KTvBy17sSLxwmHdzd3cOZtjqCEizVhqahutE9LRhnlHF1sr5kiTp9NuSXWys90ER3_fdRjHlJcpRNpWtrVQ_LWkgiOtiboUm-Q2bQudw_epPiNPvJ0LPj-eZ-Tbxw9fLz93V9efvlxeXHVOsKF2Uo0WOSg79qMXDrzgmjvOJVfDWoBXwEAq7zWzTAkpwDLwzLdLjlzdID8jrw-6S04_t-0_ZhOKw3m2EdswZoC-6TDxX5DJYf-kaqA4gC6nUjJ6s-SwsXlnGJh9HmZvttmbbTSYv3kY2dpeHvW3Nxsc75uOAbT6q2PdFmdnn210ofzT1lyu2bpv3PsDh82124DZFBcwOhxDRlfNmMLDg_wBFdSn6w</recordid><startdate>19900921</startdate><enddate>19900921</enddate><creator>Genazzani, Andrea R.</creator><creator>De Ramundo, Biagina M.</creator><creator>Criscuolo, Mario</creator><creator>De Gaetani, Carmela</creator><creator>Ficarra, Guido</creator><creator>Genazzani, Alessandro D.</creator><creator>Petraglia, Felice</creator><creator>Trentini, Gian P.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19900921</creationdate><title>Acetyl-l-carnitine restores the daily pattern of hypothalamic β-endorphin in rats exposed to continuous light</title><author>Genazzani, Andrea R. ; De Ramundo, Biagina M. ; Criscuolo, Mario ; De Gaetani, Carmela ; Ficarra, Guido ; Genazzani, Alessandro D. ; Petraglia, Felice ; Trentini, Gian P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c418t-57dae307ad2df4c0f4393c335378640f701057ff91a174540a10f1f1053e37be3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Acetyl-l-carnitine</topic><topic>Acetylcarnitine - pharmacology</topic><topic>Animals</topic><topic>beta-Endorphin - metabolism</topic><topic>Biological and medical sciences</topic><topic>Circadian rhythm</topic><topic>Circadian Rhythm - drug effects</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hormones and neuropeptides. Regulation</topic><topic>Hypothalamus - drug effects</topic><topic>Hypothalamus - metabolism</topic><topic>Hypothalamus-pituitary-gonadal axis</topic><topic>Hypothalamus. Hypophysis. Epiphysis. Urophysis</topic><topic>Light</topic><topic>Radioimmunoassay</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Vertebrates: endocrinology</topic><topic>β-Endorphin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Genazzani, Andrea R.</creatorcontrib><creatorcontrib>De Ramundo, Biagina M.</creatorcontrib><creatorcontrib>Criscuolo, Mario</creatorcontrib><creatorcontrib>De Gaetani, Carmela</creatorcontrib><creatorcontrib>Ficarra, Guido</creatorcontrib><creatorcontrib>Genazzani, Alessandro D.</creatorcontrib><creatorcontrib>Petraglia, Felice</creatorcontrib><creatorcontrib>Trentini, Gian P.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Genazzani, Andrea R.</au><au>De Ramundo, Biagina M.</au><au>Criscuolo, Mario</au><au>De Gaetani, Carmela</au><au>Ficarra, Guido</au><au>Genazzani, Alessandro D.</au><au>Petraglia, Felice</au><au>Trentini, Gian P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Acetyl-l-carnitine restores the daily pattern of hypothalamic β-endorphin in rats exposed to continuous light</atitle><jtitle>European journal of pharmacology</jtitle><addtitle>Eur J Pharmacol</addtitle><date>1990-09-21</date><risdate>1990</risdate><volume>186</volume><issue>2</issue><spage>177</spage><epage>180</epage><pages>177-180</pages><issn>0014-2999</issn><eissn>1879-0712</eissn><coden>EJPHAZ</coden><abstract>With the aim of evaluating the effect of acetyl-l-carnitine (ALC) on the daily pattern of hypothalamic β-endorphin (β-EP), we studied the effect of chronic treatment with ALC on hypothalamic β-EP contents after suppression of the dark-phase of the light-dark cycle in female rats. We evaluated the hypothalamic content of β-EP immunoreactivity every 3 h for 24 h in: (1) female rats treated with ALC for 15 days; (2) female rats treated with ALC for 15 days and exposed to continuous light for 24 h. The concentration of β-EP immunoreactivity in tissue extracts was measured by radioimmunoassay. The results demonstrate that concentrations of β-EP immunoreactivity in the medial basal hypothalamus show a circadian rhythm, with β-EP immunoreactivity levels being higher during the night than during the rest of the day. Exposure to continuous light for 24 h abolished the nocturnal increase in hypothalamic β-EP immunoreactivity. Rats treated with ALC showed a daily pattern in the β-EP content of the medial basal hypothalamus similar to that of control rats. These data emphasize the possible role of ALC in restoring or maintaining the endogenous rhythmicity of central β-EP.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>2289524</pmid><doi>10.1016/0014-2999(90)90431-5</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0014-2999 |
| ispartof | European journal of pharmacology, 1990-09, Vol.186 (2), p.177-180 |
| issn | 0014-2999 1879-0712 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_80264014 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Acetyl-l-carnitine Acetylcarnitine - pharmacology Animals beta-Endorphin - metabolism Biological and medical sciences Circadian rhythm Circadian Rhythm - drug effects Female Fundamental and applied biological sciences. Psychology Hormones and neuropeptides. Regulation Hypothalamus - drug effects Hypothalamus - metabolism Hypothalamus-pituitary-gonadal axis Hypothalamus. Hypophysis. Epiphysis. Urophysis Light Radioimmunoassay Rats Rats, Inbred Strains Vertebrates: endocrinology β-Endorphin |
| title | Acetyl-l-carnitine restores the daily pattern of hypothalamic β-endorphin in rats exposed to continuous light |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-26T04%3A24%3A47IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Acetyl-l-carnitine%20restores%20the%20daily%20pattern%20of%20hypothalamic%20%CE%B2-endorphin%20in%20rats%20exposed%20to%20continuous%20light&rft.jtitle=European%20journal%20of%20pharmacology&rft.au=Genazzani,%20Andrea%20R.&rft.date=1990-09-21&rft.volume=186&rft.issue=2&rft.spage=177&rft.epage=180&rft.pages=177-180&rft.issn=0014-2999&rft.eissn=1879-0712&rft.coden=EJPHAZ&rft_id=info:doi/10.1016/0014-2999(90)90431-5&rft_dat=%3Cproquest_cross%3E15878647%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=15878647&rft_id=info:pmid/2289524&rft_els_id=0014299990904315&rfr_iscdi=true |