Histologic response of the myocardium to various immunosuppressor schedules in patients with dilated cardiomyopathy and diagnosis of myocarditis at endomyocardial biopsy
To analyse the histological evolution of endomyocardial biopsies from children with active myocarditis, submitted or not to immunosuppressive therapy. Four groups of patients were compared, clinically treated as follows: group I--anticongestive drugs (4 patients); group II--prednisone (5 patients);...
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| Veröffentlicht in: | Arquivos brasileiros de cardiologia 1990-05, Vol.54 (5), p.319-322 |
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| container_title | Arquivos brasileiros de cardiologia |
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| creator | Higuchi, M de L Camargo, P R Aiello, V D Mazzieri, R Snitcowsky, R Fiorelli, A Ebaid, M Pileggi, F |
| description | To analyse the histological evolution of endomyocardial biopsies from children with active myocarditis, submitted or not to immunosuppressive therapy.
Four groups of patients were compared, clinically treated as follows: group I--anticongestive drugs (4 patients); group II--prednisone (5 patients); group III--prednisone plus azathioprine (9 patients); group IV--prednisone and cyclosporine (5 patients).
No patient from group I presented any histological improvement during a mean period of 9 months, while evident histological improvement occurred in 25% of patients from group I, 67% from group III and 80% from group IV. The microscopical aspect of resolving myocarditis was only observed in patients from groups III and IV, after treatment.
The immunosuppressive therapy with azathioprine or cyclosporine plus prednisone leads to decrease of active myocarditis intensity in a higher proportion of cases than the treatment with only prednisone or no immunosuppressive drugs. |
| format | Article |
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Four groups of patients were compared, clinically treated as follows: group I--anticongestive drugs (4 patients); group II--prednisone (5 patients); group III--prednisone plus azathioprine (9 patients); group IV--prednisone and cyclosporine (5 patients).
No patient from group I presented any histological improvement during a mean period of 9 months, while evident histological improvement occurred in 25% of patients from group I, 67% from group III and 80% from group IV. The microscopical aspect of resolving myocarditis was only observed in patients from groups III and IV, after treatment.
The immunosuppressive therapy with azathioprine or cyclosporine plus prednisone leads to decrease of active myocarditis intensity in a higher proportion of cases than the treatment with only prednisone or no immunosuppressive drugs.</description><identifier>ISSN: 0066-782X</identifier><identifier>PMID: 2288519</identifier><language>por</language><publisher>Brazil</publisher><subject>Adolescent ; Azathioprine - therapeutic use ; Cardiomyopathy, Dilated - drug therapy ; Cardiomyopathy, Dilated - pathology ; Child ; Child, Preschool ; Cyclosporins - therapeutic use ; Drug Therapy, Combination ; Female ; Humans ; Immunosuppressive Agents - therapeutic use ; Infant ; Male ; Myocarditis - drug therapy ; Myocarditis - pathology ; Myocardium - pathology ; Prednisone - therapeutic use</subject><ispartof>Arquivos brasileiros de cardiologia, 1990-05, Vol.54 (5), p.319-322</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2288519$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Higuchi, M de L</creatorcontrib><creatorcontrib>Camargo, P R</creatorcontrib><creatorcontrib>Aiello, V D</creatorcontrib><creatorcontrib>Mazzieri, R</creatorcontrib><creatorcontrib>Snitcowsky, R</creatorcontrib><creatorcontrib>Fiorelli, A</creatorcontrib><creatorcontrib>Ebaid, M</creatorcontrib><creatorcontrib>Pileggi, F</creatorcontrib><title>Histologic response of the myocardium to various immunosuppressor schedules in patients with dilated cardiomyopathy and diagnosis of myocarditis at endomyocardial biopsy</title><title>Arquivos brasileiros de cardiologia</title><addtitle>Arq Bras Cardiol</addtitle><description>To analyse the histological evolution of endomyocardial biopsies from children with active myocarditis, submitted or not to immunosuppressive therapy.
Four groups of patients were compared, clinically treated as follows: group I--anticongestive drugs (4 patients); group II--prednisone (5 patients); group III--prednisone plus azathioprine (9 patients); group IV--prednisone and cyclosporine (5 patients).
No patient from group I presented any histological improvement during a mean period of 9 months, while evident histological improvement occurred in 25% of patients from group I, 67% from group III and 80% from group IV. The microscopical aspect of resolving myocarditis was only observed in patients from groups III and IV, after treatment.
The immunosuppressive therapy with azathioprine or cyclosporine plus prednisone leads to decrease of active myocarditis intensity in a higher proportion of cases than the treatment with only prednisone or no immunosuppressive drugs.</description><subject>Adolescent</subject><subject>Azathioprine - therapeutic use</subject><subject>Cardiomyopathy, Dilated - drug therapy</subject><subject>Cardiomyopathy, Dilated - pathology</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Cyclosporins - therapeutic use</subject><subject>Drug Therapy, Combination</subject><subject>Female</subject><subject>Humans</subject><subject>Immunosuppressive Agents - therapeutic use</subject><subject>Infant</subject><subject>Male</subject><subject>Myocarditis - drug therapy</subject><subject>Myocarditis - pathology</subject><subject>Myocardium - pathology</subject><subject>Prednisone - therapeutic use</subject><issn>0066-782X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kEFPhDAQhTlo1nX1J5j05I2kFChwNBt1TTbxsgdvZGiHpQZoZYqGn-S_tOruaTLzXr6XNxfRmnMp46IUb1fRNdE750IUab6KVkKUZZ5U6-h7Z8jb3h6NYhOSsyMhsy3zHbJhsQombeaBecs-YTJ2JmaGYR4tzc4FP9mJkepQzz0GaWQOvMHRE_syvmPa9OBRsz-MDbwgdwuDUQcJjgFj6DftnOTDCp7hqO35BD1rjHW03ESXLfSEt6e5iQ5Pj4ftLt6_Pr9sH_axy9Mqlk1VYVbpvElKXgAvK-SS8zRrEIqizdJccZAVNFrmiZISWilUonIQpWwUyHQT3f9j3WQ_ZiRfD4YU9j2MGOrXJRcy47wIxruTcW4G1LWbzADTUp9em_4AFHR6kA</recordid><startdate>199005</startdate><enddate>199005</enddate><creator>Higuchi, M de L</creator><creator>Camargo, P R</creator><creator>Aiello, V D</creator><creator>Mazzieri, R</creator><creator>Snitcowsky, R</creator><creator>Fiorelli, A</creator><creator>Ebaid, M</creator><creator>Pileggi, F</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>199005</creationdate><title>Histologic response of the myocardium to various immunosuppressor schedules in patients with dilated cardiomyopathy and diagnosis of myocarditis at endomyocardial biopsy</title><author>Higuchi, M de L ; Camargo, P R ; Aiello, V D ; Mazzieri, R ; Snitcowsky, R ; Fiorelli, A ; Ebaid, M ; Pileggi, F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p539-6b99e49d5b1807a089e060034bea77f435c0a69abd651c66af62c1c5a286bca63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>por</language><creationdate>1990</creationdate><topic>Adolescent</topic><topic>Azathioprine - therapeutic use</topic><topic>Cardiomyopathy, Dilated - drug therapy</topic><topic>Cardiomyopathy, Dilated - pathology</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Cyclosporins - therapeutic use</topic><topic>Drug Therapy, Combination</topic><topic>Female</topic><topic>Humans</topic><topic>Immunosuppressive Agents - therapeutic use</topic><topic>Infant</topic><topic>Male</topic><topic>Myocarditis - drug therapy</topic><topic>Myocarditis - pathology</topic><topic>Myocardium - pathology</topic><topic>Prednisone - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Higuchi, M de L</creatorcontrib><creatorcontrib>Camargo, P R</creatorcontrib><creatorcontrib>Aiello, V D</creatorcontrib><creatorcontrib>Mazzieri, R</creatorcontrib><creatorcontrib>Snitcowsky, R</creatorcontrib><creatorcontrib>Fiorelli, A</creatorcontrib><creatorcontrib>Ebaid, M</creatorcontrib><creatorcontrib>Pileggi, F</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Arquivos brasileiros de cardiologia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Higuchi, M de L</au><au>Camargo, P R</au><au>Aiello, V D</au><au>Mazzieri, R</au><au>Snitcowsky, R</au><au>Fiorelli, A</au><au>Ebaid, M</au><au>Pileggi, F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Histologic response of the myocardium to various immunosuppressor schedules in patients with dilated cardiomyopathy and diagnosis of myocarditis at endomyocardial biopsy</atitle><jtitle>Arquivos brasileiros de cardiologia</jtitle><addtitle>Arq Bras Cardiol</addtitle><date>1990-05</date><risdate>1990</risdate><volume>54</volume><issue>5</issue><spage>319</spage><epage>322</epage><pages>319-322</pages><issn>0066-782X</issn><abstract>To analyse the histological evolution of endomyocardial biopsies from children with active myocarditis, submitted or not to immunosuppressive therapy.
Four groups of patients were compared, clinically treated as follows: group I--anticongestive drugs (4 patients); group II--prednisone (5 patients); group III--prednisone plus azathioprine (9 patients); group IV--prednisone and cyclosporine (5 patients).
No patient from group I presented any histological improvement during a mean period of 9 months, while evident histological improvement occurred in 25% of patients from group I, 67% from group III and 80% from group IV. The microscopical aspect of resolving myocarditis was only observed in patients from groups III and IV, after treatment.
The immunosuppressive therapy with azathioprine or cyclosporine plus prednisone leads to decrease of active myocarditis intensity in a higher proportion of cases than the treatment with only prednisone or no immunosuppressive drugs.</abstract><cop>Brazil</cop><pmid>2288519</pmid><tpages>4</tpages></addata></record> |
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| identifier | ISSN: 0066-782X |
| ispartof | Arquivos brasileiros de cardiologia, 1990-05, Vol.54 (5), p.319-322 |
| issn | 0066-782X |
| language | por |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adolescent Azathioprine - therapeutic use Cardiomyopathy, Dilated - drug therapy Cardiomyopathy, Dilated - pathology Child Child, Preschool Cyclosporins - therapeutic use Drug Therapy, Combination Female Humans Immunosuppressive Agents - therapeutic use Infant Male Myocarditis - drug therapy Myocarditis - pathology Myocardium - pathology Prednisone - therapeutic use |
| title | Histologic response of the myocardium to various immunosuppressor schedules in patients with dilated cardiomyopathy and diagnosis of myocarditis at endomyocardial biopsy |
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