Antipyrine and Acetaminophen Kinetics in the Rat: Comparison of Data Based on Blood Samples from the Cut Tail and a Cannulated Femoral Artery

Antipyrine and acetaminophen kinetics were determined from concentration data obtained by simultaneous blood sampling from the cut end of the tail and a cannulated femoral artery in the rat. Significant differences in concentrations and kinetics for both drugs were found by comparison of the two sam...

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Veröffentlicht in:	Journal of pharmaceutical sciences 1982-12, Vol.71 (12), p.1352-1356
Hauptverfasser:	Johannessen, Wenche M., Tyssebotn, Ingvald M., Aarbakke, Jarle
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetaminophen - blood Acetaminophen - metabolism Acetaminophen-pharmacokinetics in the rat Acetaminophen—pharmacokinetics in the rat, comparison of data based on blood samples from the cut tail and a cannulated femoral artery Animals Antipyrine - blood Antipyrine - metabolism Antipyrine-pharmacokinetics in the rat Antipyrine—pharmacokinetics in the rat, comparison of data based on blood samples from the cut tail and a cannulated femoral artery Blood Specimen Collection comparison of data based on blood samples from the cut tail and a cannulated femoral artery Femoral Artery Keyphrases Kinetics Male Microsphere technique-pharmacokinetics in the rat Microsphere technique—pharmacokinetics in the rat, comparison of data based on blood samples from the cut tail and a cannulated femoral artery Pharmacokinetics-acetaminophen and antipyrine in the rat Pharmacokinetics—acetaminophen and antipyrine in the rat, comparison of data based on blood samples from the cut tail and a cannulated femoral artery Rats Rats, Inbred Strains Tail - blood supply
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