Failure of the lipid peroxidation inhibitor U74006F to improve neurological outcome after transient forebrain ischemia in the rat
The lipid peroxidation inhibitor U74006F (21-[4-(2,6-di-1-pyrrolidinyl-4-pyyrimidinyl)-1-piperazinyl-16-methypregna-1,4,9 (11)-triene-3, 20-dione) was tested for cerebroprotective properties in the rat. Transient forebrain ischemia was induced by occlusion of the carotid arteries and simultaneous lo...
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| Veröffentlicht in: | Brain research 1990-11, Vol.532 (1), p.336-338 |
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| container_title | Brain research |
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| creator | Beck, Thomas Bielenberg, Gerhard Wilhelm |
| description | The lipid peroxidation inhibitor U74006F (21-[4-(2,6-di-1-pyrrolidinyl-4-pyyrimidinyl)-1-piperazinyl-16-methypregna-1,4,9 (11)-triene-3, 20-dione) was tested for cerebroprotective properties in the rat. Transient forebrain ischemia was induced by occlusion of the carotid arteries and simultaneous lowering of the blood pressure to 40 mmHg. Repetitive doses of 10 mg/kg U74006F were administered intraperitoneally 10 min before and again 30 min and 24 h after the transient forebrain ischemia. U74006F did not significantly improve histological outcome in this model, suggesting lipid peroxidation to be a minor determinatinant forneurological, outcome under these experimental outcome under these experimental conditions |
| doi_str_mv | 10.1016/0006-8993(90)91779-G |
| format | Article |
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Transient forebrain ischemia was induced by occlusion of the carotid arteries and simultaneous lowering of the blood pressure to 40 mmHg. Repetitive doses of 10 mg/kg U74006F were administered intraperitoneally 10 min before and again 30 min and 24 h after the transient forebrain ischemia. U74006F did not significantly improve histological outcome in this model, suggesting lipid peroxidation to be a minor determinatinant forneurological, outcome under these experimental outcome under these experimental conditions</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/0006-8993(90)91779-G</identifier><identifier>PMID: 2282527</identifier><identifier>CODEN: BRREAP</identifier><language>eng</language><publisher>London: Elsevier B.V</publisher><subject>Animals ; Biological and medical sciences ; Cell Survival - drug effects ; Forebrain ischemia ; Hippocampus - pathology ; Ischemic Attack, Transient - drug therapy ; Ischemic Attack, Transient - pathology ; Lipid peroxidation inhibitor ; Lipid Peroxides - antagonists & inhibitors ; Male ; Medical sciences ; Miscellaneous ; Necrosis ; Neurons - pathology ; Neuropharmacology ; Pharmacology. Drug treatments ; Pregnatrienes - therapeutic use ; Prognosis ; Rats ; Rats, Inbred Strains ; Two-vessel occlusion ; U74006F</subject><ispartof>Brain research, 1990-11, Vol.532 (1), p.336-338</ispartof><rights>1990 Elsevier Science Publishers B.V. (Biomedical Division)</rights><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c418t-783aa9a713c4c433a4ae30051409f8ec6a96ca963037d8ea95dd300450aecde43</citedby><cites>FETCH-LOGICAL-c418t-783aa9a713c4c433a4ae30051409f8ec6a96ca963037d8ea95dd300450aecde43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/000689939091779G$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19455135$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2282527$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Beck, Thomas</creatorcontrib><creatorcontrib>Bielenberg, Gerhard Wilhelm</creatorcontrib><title>Failure of the lipid peroxidation inhibitor U74006F to improve neurological outcome after transient forebrain ischemia in the rat</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>The lipid peroxidation inhibitor U74006F (21-[4-(2,6-di-1-pyrrolidinyl-4-pyyrimidinyl)-1-piperazinyl-16-methypregna-1,4,9 (11)-triene-3, 20-dione) was tested for cerebroprotective properties in the rat. Transient forebrain ischemia was induced by occlusion of the carotid arteries and simultaneous lowering of the blood pressure to 40 mmHg. Repetitive doses of 10 mg/kg U74006F were administered intraperitoneally 10 min before and again 30 min and 24 h after the transient forebrain ischemia. U74006F did not significantly improve histological outcome in this model, suggesting lipid peroxidation to be a minor determinatinant forneurological, outcome under these experimental outcome under these experimental conditions</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cell Survival - drug effects</subject><subject>Forebrain ischemia</subject><subject>Hippocampus - pathology</subject><subject>Ischemic Attack, Transient - drug therapy</subject><subject>Ischemic Attack, Transient - pathology</subject><subject>Lipid peroxidation inhibitor</subject><subject>Lipid Peroxides - antagonists & inhibitors</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Miscellaneous</subject><subject>Necrosis</subject><subject>Neurons - pathology</subject><subject>Neuropharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Pregnatrienes - therapeutic use</subject><subject>Prognosis</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Two-vessel occlusion</subject><subject>U74006F</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcFrFDEUxoNY6lr9DxRyUexhNJlkJslFkOKuQqEXew5vkzduZGayJplij_7nZrtLvekhhPC-9-Xj9xHyirP3nPH-A2Osb7Qx4p1hl4YrZZrNE7LiWrVN30r2lKweJc_I85x_1KcQhp2T87bVbdeqFfm9hjAuCWkcaNkhHcM-eLrHFH8FDyXEmYZ5F7ahxERvlayGa1oiDdM-xTukMy4pjvF7cDDSuBQXJ6QwFEy0JJhzwLnQISbcJgjVK7sdTgGq6cN3CcoLcjbAmPHl6b4gt-vP366-NNc3m69Xn64bJ7kujdICwIDiwkknhQAJKBjruGRm0Oh6ML2rRzChvEYwnfd1LjsG6DxKcUHeHn1r8J8L5mKnmgbHEWaMS7aatdKYSuh_Qt5ppnrVV6E8Cl2KOScc7D6FCdK95cweKrIH_vbA3xpmHyqym7r2-uS_bCf0j0unTur8zWkOuVIdKkYX8l9vI7uOi67qPh51WKndBUw2u4rboQ8JXbE-hn8H-QMHGK5Z</recordid><startdate>19901105</startdate><enddate>19901105</enddate><creator>Beck, Thomas</creator><creator>Bielenberg, Gerhard Wilhelm</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19901105</creationdate><title>Failure of the lipid peroxidation inhibitor U74006F to improve neurological outcome after transient forebrain ischemia in the rat</title><author>Beck, Thomas ; Bielenberg, Gerhard Wilhelm</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c418t-783aa9a713c4c433a4ae30051409f8ec6a96ca963037d8ea95dd300450aecde43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cell Survival - drug effects</topic><topic>Forebrain ischemia</topic><topic>Hippocampus - pathology</topic><topic>Ischemic Attack, Transient - drug therapy</topic><topic>Ischemic Attack, Transient - pathology</topic><topic>Lipid peroxidation inhibitor</topic><topic>Lipid Peroxides - antagonists & inhibitors</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Miscellaneous</topic><topic>Necrosis</topic><topic>Neurons - pathology</topic><topic>Neuropharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Pregnatrienes - therapeutic use</topic><topic>Prognosis</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Two-vessel occlusion</topic><topic>U74006F</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Beck, Thomas</creatorcontrib><creatorcontrib>Bielenberg, Gerhard Wilhelm</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Beck, Thomas</au><au>Bielenberg, Gerhard Wilhelm</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Failure of the lipid peroxidation inhibitor U74006F to improve neurological outcome after transient forebrain ischemia in the rat</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>1990-11-05</date><risdate>1990</risdate><volume>532</volume><issue>1</issue><spage>336</spage><epage>338</epage><pages>336-338</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>The lipid peroxidation inhibitor U74006F (21-[4-(2,6-di-1-pyrrolidinyl-4-pyyrimidinyl)-1-piperazinyl-16-methypregna-1,4,9 (11)-triene-3, 20-dione) was tested for cerebroprotective properties in the rat. Transient forebrain ischemia was induced by occlusion of the carotid arteries and simultaneous lowering of the blood pressure to 40 mmHg. Repetitive doses of 10 mg/kg U74006F were administered intraperitoneally 10 min before and again 30 min and 24 h after the transient forebrain ischemia. U74006F did not significantly improve histological outcome in this model, suggesting lipid peroxidation to be a minor determinatinant forneurological, outcome under these experimental outcome under these experimental conditions</abstract><cop>London</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>2282527</pmid><doi>10.1016/0006-8993(90)91779-G</doi><tpages>3</tpages></addata></record> |
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| ispartof | Brain research, 1990-11, Vol.532 (1), p.336-338 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Biological and medical sciences Cell Survival - drug effects Forebrain ischemia Hippocampus - pathology Ischemic Attack, Transient - drug therapy Ischemic Attack, Transient - pathology Lipid peroxidation inhibitor Lipid Peroxides - antagonists & inhibitors Male Medical sciences Miscellaneous Necrosis Neurons - pathology Neuropharmacology Pharmacology. Drug treatments Pregnatrienes - therapeutic use Prognosis Rats Rats, Inbred Strains Two-vessel occlusion U74006F |
| title | Failure of the lipid peroxidation inhibitor U74006F to improve neurological outcome after transient forebrain ischemia in the rat |
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