Beta-2 microglobulin--an immunogenetic marker of inflammatory and malignant origin
Major contributions have been made in the last few years to the knowledge of the structure, fate and cellular origin of beta-2 microglobulin (B2M); but the question of its function still remains unclear. The concept of B2M being simply a marker of renal physiology seems less satisfactory when refere...
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| Veröffentlicht in: | Annals of clinical and laboratory science 1982-11, Vol.12 (6), p.447-452 |
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| container_end_page | 452 |
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| container_title | Annals of clinical and laboratory science |
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| creator | Forman, D T |
| description | Major contributions have been made in the last few years to the knowledge of the structure, fate and cellular origin of beta-2 microglobulin (B2M); but the question of its function still remains unclear. The concept of B2M being simply a marker of renal physiology seems less satisfactory when reference is made to its relationship to the immunogenetic system. Although assay of B2M cannot be considered as a specific diagnostic tool, it still may be regarded as a useful parameter in monitoring inflammatory, malignant, and auto-immune disease activity. |
| format | Article |
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The concept of B2M being simply a marker of renal physiology seems less satisfactory when reference is made to its relationship to the immunogenetic system. Although assay of B2M cannot be considered as a specific diagnostic tool, it still may be regarded as a useful parameter in monitoring inflammatory, malignant, and auto-immune disease activity.</description><identifier>ISSN: 0091-7370</identifier><identifier>PMID: 6185038</identifier><language>eng</language><publisher>United States</publisher><subject>beta 2-Microglobulin - analysis ; beta 2-Microglobulin - genetics ; beta 2-Microglobulin - immunology ; Beta-Globulins - immunology ; Breast Neoplasms - diagnosis ; Breast Neoplasms - immunology ; Carcinoma, Bronchogenic - diagnosis ; Carcinoma, Bronchogenic - immunology ; Chemical Phenomena ; Chemistry ; Female ; Gastrointestinal Neoplasms - diagnosis ; Gastrointestinal Neoplasms - immunology ; HLA Antigens - genetics ; HLA Antigens - immunology ; Humans ; Inflammation - blood ; Inflammation - diagnosis ; Inflammation - immunology ; Leukemia - diagnosis ; Leukemia - immunology ; Lung Neoplasms - diagnosis ; Lung Neoplasms - immunology ; Lymphocyte Activation ; Lymphoma - diagnosis ; Lymphoma - immunology ; Male</subject><ispartof>Annals of clinical and laboratory science, 1982-11, Vol.12 (6), p.447-452</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6185038$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Forman, D T</creatorcontrib><title>Beta-2 microglobulin--an immunogenetic marker of inflammatory and malignant origin</title><title>Annals of clinical and laboratory science</title><addtitle>Ann Clin Lab Sci</addtitle><description>Major contributions have been made in the last few years to the knowledge of the structure, fate and cellular origin of beta-2 microglobulin (B2M); but the question of its function still remains unclear. The concept of B2M being simply a marker of renal physiology seems less satisfactory when reference is made to its relationship to the immunogenetic system. 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The concept of B2M being simply a marker of renal physiology seems less satisfactory when reference is made to its relationship to the immunogenetic system. Although assay of B2M cannot be considered as a specific diagnostic tool, it still may be regarded as a useful parameter in monitoring inflammatory, malignant, and auto-immune disease activity.</abstract><cop>United States</cop><pmid>6185038</pmid><tpages>6</tpages></addata></record> |
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| ispartof | Annals of clinical and laboratory science, 1982-11, Vol.12 (6), p.447-452 |
| issn | 0091-7370 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_80245356 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | beta 2-Microglobulin - analysis beta 2-Microglobulin - genetics beta 2-Microglobulin - immunology Beta-Globulins - immunology Breast Neoplasms - diagnosis Breast Neoplasms - immunology Carcinoma, Bronchogenic - diagnosis Carcinoma, Bronchogenic - immunology Chemical Phenomena Chemistry Female Gastrointestinal Neoplasms - diagnosis Gastrointestinal Neoplasms - immunology HLA Antigens - genetics HLA Antigens - immunology Humans Inflammation - blood Inflammation - diagnosis Inflammation - immunology Leukemia - diagnosis Leukemia - immunology Lung Neoplasms - diagnosis Lung Neoplasms - immunology Lymphocyte Activation Lymphoma - diagnosis Lymphoma - immunology Male |
| title | Beta-2 microglobulin--an immunogenetic marker of inflammatory and malignant origin |
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