A cleavage method which minimizes side reactions following Fmoc solid phase peptide synthesis

The success of solid phase peptide synthesis utilizing 9‐fluorenylmethoxycarbonyl (Fmoc) amino acids is often limited by deleterious side reactions which occur during TFA peptide‐resin cleavage and side‐chain deprotection. The majority of these side reactions modify susceptible residues, such as Trp...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	International Journal of Peptide and Protein Research 1990-09, Vol.36 (3), p.255-266
Hauptverfasser:	KING, DAVID S., FIELDS, CYNTHIA G., FIELDS, GREGG B.
Format:	Artikel
Sprache:	eng
Schlagworte:	9-fluorenylmethoxycarbonyl (Fmoc) amino acids Amino Acid Sequence Amino Acids Chemistry Chromatography, High Pressure Liquid Exact sciences and technology Fluorenes Mercaptoethanol - analogs & derivatives Methods Molecular Sequence Data Organic chemistry Peptides Peptides - chemical synthesis Peptides - isolation & purification Preparations and properties side reactions solid phase peptide synthesis Trifluoroacetic Acid weak acid cleavage
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!