Activation by thymidine kinase and potent antiherpetic activity of 2′-nor-2′-deoxyguanosine (2′NDG)

In an investigation of the substrate specificity of herpes simplex type I (HSV-1) thymidine kinase, certain chemical analogs of acyclovir were prepared. One of these, 9-[(2-hydroxy-1-(hydroxymethyl)ethoxy)methyl]guanine (2′-nor-2′-deoxyguanosine, 2′NDG), prepared in a five-step convergent synthesis...

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