Rapid, Simultaneous Quantification of Morphine, Codeine, and Hydromorphone by GC/MS
Morphine, codeine, and hydromorphone were extracted from blood or serum using a one step extraction. The extract was derivatized and the trifluoroacetyl opiates were quantified by GC/MS selected ion monitoring (SIM) using nalorphine as the internal standard. Calibration curves were linear and sensit...
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| Veröffentlicht in: | Journal of analytical toxicology 1982-09, Vol.6 (5), p.235-237 |
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| container_end_page | 237 |
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| container_issue | 5 |
| container_start_page | 235 |
| container_title | Journal of analytical toxicology |
| container_volume | 6 |
| creator | Saady, Joseph J. Narasimhachari, N. Blanke, Robert V. |
| description | Morphine, codeine, and hydromorphone were extracted from blood or serum using a one step extraction. The extract was derivatized and the trifluoroacetyl opiates were quantified by GC/MS selected ion monitoring (SIM) using nalorphine as the internal standard. Calibration curves were linear and sensitivity as low as .02 mg/L for morphine and codeine, and .08 mg/L for hydromorphone, was achieved. Urine or tissue homogenates could be processed similarly after acid hydrolysis. |
| doi_str_mv | 10.1093/jat/6.5.235 |
| format | Article |
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The extract was derivatized and the trifluoroacetyl opiates were quantified by GC/MS selected ion monitoring (SIM) using nalorphine as the internal standard. Calibration curves were linear and sensitivity as low as .02 mg/L for morphine and codeine, and .08 mg/L for hydromorphone, was achieved. 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The extract was derivatized and the trifluoroacetyl opiates were quantified by GC/MS selected ion monitoring (SIM) using nalorphine as the internal standard. Calibration curves were linear and sensitivity as low as .02 mg/L for morphine and codeine, and .08 mg/L for hydromorphone, was achieved. Urine or tissue homogenates could be processed similarly after acid hydrolysis.</description><subject>Autoanalysis</subject><subject>Blood</subject><subject>Codeine</subject><subject>Codeine - analysis</subject><subject>Gas Chromatography-Mass Spectrometry</subject><subject>Guanylate cyclase</subject><subject>Humans</subject><subject>Hydrolysis</subject><subject>Hydromorphone - analysis</subject><subject>Morphine</subject><subject>Morphine - analysis</subject><subject>Opiates</subject><subject>trifluoroacetyl</subject><subject>Urine</subject><issn>0146-4760</issn><issn>1945-2403</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1982</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqN0c9r2zAUB3AxVtK022nngk9j0DrR00_7uIW2aWg2lrQQdhGyLTFlsZVZNjT_fdUm9Nj2pAffD48nvgh9ATwCnNPxWndjMeIjQvkHNISc8ZQwTD-iIQYmUiYFPkYnIawxBpEJOkADARnjTAzRcqG3rrpIlq7uN51ujO9D8rvXTeesK3XnfJN4m8x9u_3rGnORTHxlngfdVMl0V7W-fsp8Y5Jil1xPxvPlJ3Rk9SaYz4f3FN1fXd5Npuntr-ubyffbtGQguxQ4h9KQPMMcW6kLK01RMVLQsgBMIDMmoxJLwCURtgKiweYaCmCcFlBqS0_R1_3ebev_9yZ0qnahNJvN_hsqw4RSSfibMF5Cc-DZeyAwBnmE316HsZd4J3Ac6fmelq0PoTVWbVtX63YX0bNTsT8lFFexv6jPDov7ojbViz0UFvN0n7vQmYeXWLf_lJBUcjVd_VGzHwu6-smXakYfAfbro2g</recordid><startdate>198209</startdate><enddate>198209</enddate><creator>Saady, Joseph J.</creator><creator>Narasimhachari, N.</creator><creator>Blanke, Robert V.</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>198209</creationdate><title>Rapid, Simultaneous Quantification of Morphine, Codeine, and Hydromorphone by GC/MS</title><author>Saady, Joseph J. ; Narasimhachari, N. ; Blanke, Robert V.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-1551ce298050f7abf7ebd42b3cb10218ee8370710c26fd12a1f9a1b1453b1caf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1982</creationdate><topic>Autoanalysis</topic><topic>Blood</topic><topic>Codeine</topic><topic>Codeine - analysis</topic><topic>Gas Chromatography-Mass Spectrometry</topic><topic>Guanylate cyclase</topic><topic>Humans</topic><topic>Hydrolysis</topic><topic>Hydromorphone - analysis</topic><topic>Morphine</topic><topic>Morphine - analysis</topic><topic>Opiates</topic><topic>trifluoroacetyl</topic><topic>Urine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Saady, Joseph J.</creatorcontrib><creatorcontrib>Narasimhachari, N.</creatorcontrib><creatorcontrib>Blanke, Robert V.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of analytical toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Saady, Joseph J.</au><au>Narasimhachari, N.</au><au>Blanke, Robert V.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Rapid, Simultaneous Quantification of Morphine, Codeine, and Hydromorphone by GC/MS</atitle><jtitle>Journal of analytical toxicology</jtitle><addtitle>Journal of Analytical Toxicology</addtitle><date>1982-09</date><risdate>1982</risdate><volume>6</volume><issue>5</issue><spage>235</spage><epage>237</epage><pages>235-237</pages><issn>0146-4760</issn><eissn>1945-2403</eissn><abstract>Morphine, codeine, and hydromorphone were extracted from blood or serum using a one step extraction. The extract was derivatized and the trifluoroacetyl opiates were quantified by GC/MS selected ion monitoring (SIM) using nalorphine as the internal standard. Calibration curves were linear and sensitivity as low as .02 mg/L for morphine and codeine, and .08 mg/L for hydromorphone, was achieved. Urine or tissue homogenates could be processed similarly after acid hydrolysis.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>6184546</pmid><doi>10.1093/jat/6.5.235</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0146-4760 |
| ispartof | Journal of analytical toxicology, 1982-09, Vol.6 (5), p.235-237 |
| issn | 0146-4760 1945-2403 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_80233725 |
| source | MEDLINE; Oxford University Press Archive; Alma/SFX Local Collection |
| subjects | Autoanalysis Blood Codeine Codeine - analysis Gas Chromatography-Mass Spectrometry Guanylate cyclase Humans Hydrolysis Hydromorphone - analysis Morphine Morphine - analysis Opiates trifluoroacetyl Urine |
| title | Rapid, Simultaneous Quantification of Morphine, Codeine, and Hydromorphone by GC/MS |
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