Rapid, Simultaneous Quantification of Morphine, Codeine, and Hydromorphone by GC/MS

Rapid, Simultaneous Quantification of Morphine, Codeine, and Hydromorphone by GC/MS

Morphine, codeine, and hydromorphone were extracted from blood or serum using a one step extraction. The extract was derivatized and the trifluoroacetyl opiates were quantified by GC/MS selected ion monitoring (SIM) using nalorphine as the internal standard. Calibration curves were linear and sensit...

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Veröffentlicht in:Journal of analytical toxicology 1982-09, Vol.6 (5), p.235-237
Hauptverfasser: Saady, Joseph J., Narasimhachari, N., Blanke, Robert V.
Format: Artikel
Sprache:eng
Schlagworte:
Autoanalysis
Blood
Codeine
Codeine - analysis
Gas Chromatography-Mass Spectrometry
Guanylate cyclase
Humans
Hydrolysis
Hydromorphone - analysis
Morphine
Morphine - analysis
Opiates
trifluoroacetyl
Urine
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Beschreibung
Zusammenfassung:Morphine, codeine, and hydromorphone were extracted from blood or serum using a one step extraction. The extract was derivatized and the trifluoroacetyl opiates were quantified by GC/MS selected ion monitoring (SIM) using nalorphine as the internal standard. Calibration curves were linear and sensitivity as low as .02 mg/L for morphine and codeine, and .08 mg/L for hydromorphone, was achieved. Urine or tissue homogenates could be processed similarly after acid hydrolysis.
ISSN:0146-4760
1945-2403
DOI:10.1093/jat/6.5.235