Intrathecal anti-tetanus serum (ATS) and parenteral betamethasone in the treatment of tetanus
217 cases of tetanus admitted to Christian Medical College and Brown Memorial Hospital, Ludhiana, from June 1977 to April 1980 were studied. Three treatment regimes were used during this period. The addition of intrathecal horse antitetanus serum (ATS) (Group II) to the routine treatment (Group I) r...
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| Veröffentlicht in: | Transactions of the Royal Society of Tropical Medicine and Hygiene 1982, Vol.76 (5), p.620-623 |
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| container_title | Transactions of the Royal Society of Tropical Medicine and Hygiene |
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| creator | Thomas, Paulose P. Crowell, Edward B. Mathew, Mary |
| description | 217 cases of tetanus admitted to Christian Medical College and Brown Memorial Hospital, Ludhiana, from June 1977 to April 1980 were studied. Three treatment regimes were used during this period. The addition of intrathecal horse antitetanus serum (ATS) (Group II) to the routine treatment (Group I) reduced the mortality from 63% to 53% but this was not statistically significant. Following a further addition of parenteral betamethasone to the regimen (Group III) the mortality decreased to 27% which was significantly lower than in Groups I and II. A similar trend in mortality was demonstrated when the severe cases were analysed separately. Groups I and III were comparable in terms of various prognostic factors and the nursing care received but Group II had a higher incidence of unfavourable prognostic factors, which may have obscured the benefit of intrathecal ATS. The combination of parenteral betamethasone and intrathecal ATS seems to be beneficial in the treatment of tetanus. |
| doi_str_mv | 10.1016/0035-9203(82)90224-3 |
| format | Article |
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Three treatment regimes were used during this period. The addition of intrathecal horse antitetanus serum (ATS) (Group II) to the routine treatment (Group I) reduced the mortality from 63% to 53% but this was not statistically significant. Following a further addition of parenteral betamethasone to the regimen (Group III) the mortality decreased to 27% which was significantly lower than in Groups I and II. A similar trend in mortality was demonstrated when the severe cases were analysed separately. Groups I and III were comparable in terms of various prognostic factors and the nursing care received but Group II had a higher incidence of unfavourable prognostic factors, which may have obscured the benefit of intrathecal ATS. 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Three treatment regimes were used during this period. The addition of intrathecal horse antitetanus serum (ATS) (Group II) to the routine treatment (Group I) reduced the mortality from 63% to 53% but this was not statistically significant. Following a further addition of parenteral betamethasone to the regimen (Group III) the mortality decreased to 27% which was significantly lower than in Groups I and II. A similar trend in mortality was demonstrated when the severe cases were analysed separately. Groups I and III were comparable in terms of various prognostic factors and the nursing care received but Group II had a higher incidence of unfavourable prognostic factors, which may have obscured the benefit of intrathecal ATS. The combination of parenteral betamethasone and intrathecal ATS seems to be beneficial in the treatment of tetanus.</description><subject>Adult</subject><subject>Betamethasone - therapeutic use</subject><subject>Clostridium tetani</subject><subject>Female</subject><subject>Humans</subject><subject>Injections, Spinal</subject><subject>Male</subject><subject>Tetanus - mortality</subject><subject>Tetanus - therapy</subject><subject>Tetanus Antitoxin - administration & dosage</subject><subject>Tetanus Antitoxin - therapeutic use</subject><issn>0035-9203</issn><issn>1878-3503</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1982</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkF1LHDEYhUOxbNdt_4FCrkQvpuZzktwURPyCBaXdQimUEDPvYNqdmTXJiP33Zt1lL_UqkPOcw8uD0AElXymh9SkhXFaGEX6s2YkhjImKf0BTqpWuuCR8D013yCe0n9JfQpik0kzQpNZGiVpO0Z-bPkeXH8C7JXZ9DlWG7Pox4QRx7PDx2eLHSQkavHIR-gyxcPcF6SA_uDT0gEOPSx_nCC53BcFDi7cjn9HH1i0TfNm-M_Tz8mJxfl3Nb69uzs_mlReszhXljdDlNtIq4RkxAowDaCgBACWcNo2E1sm6Bm-Ia8uvNKTAXmsnGyB8ho42u6s4PI6Qsu1C8rBcuh6GMdkyzpkW74OUS6O0ogUUG9DHIaUIrV3F0Ln431Ji1_rt2q1du7Wa2Vf9lpfa4XZ_vO-g2ZW2vktebfKQMjzvYhf_2VpxJe31r9-2OLmT3xfKzgv_bcNDsfcUINrkA_QemhDBZ9sM4e2DXgBf7aPH</recordid><startdate>1982</startdate><enddate>1982</enddate><creator>Thomas, Paulose P.</creator><creator>Crowell, Edward B.</creator><creator>Mathew, Mary</creator><general>Elsevier Ltd</general><general>Royal Society of Tropical Medicine and Hygiene</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>1982</creationdate><title>Intrathecal anti-tetanus serum (ATS) and parenteral betamethasone in the treatment of tetanus</title><author>Thomas, Paulose P. ; Crowell, Edward B. ; Mathew, Mary</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c426t-13d480250f74c2094e9aeed10eee74a89d5efa566ec90afeee5900f7c88a5de03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1982</creationdate><topic>Adult</topic><topic>Betamethasone - therapeutic use</topic><topic>Clostridium tetani</topic><topic>Female</topic><topic>Humans</topic><topic>Injections, Spinal</topic><topic>Male</topic><topic>Tetanus - mortality</topic><topic>Tetanus - therapy</topic><topic>Tetanus Antitoxin - administration & dosage</topic><topic>Tetanus Antitoxin - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Thomas, Paulose P.</creatorcontrib><creatorcontrib>Crowell, Edward B.</creatorcontrib><creatorcontrib>Mathew, Mary</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>Transactions of the Royal Society of Tropical Medicine and Hygiene</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Thomas, Paulose P.</au><au>Crowell, Edward B.</au><au>Mathew, Mary</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intrathecal anti-tetanus serum (ATS) and parenteral betamethasone in the treatment of tetanus</atitle><jtitle>Transactions of the Royal Society of Tropical Medicine and Hygiene</jtitle><addtitle>Trans R Soc Trop Med Hyg</addtitle><date>1982</date><risdate>1982</risdate><volume>76</volume><issue>5</issue><spage>620</spage><epage>623</epage><pages>620-623</pages><issn>0035-9203</issn><eissn>1878-3503</eissn><abstract>217 cases of tetanus admitted to Christian Medical College and Brown Memorial Hospital, Ludhiana, from June 1977 to April 1980 were studied. Three treatment regimes were used during this period. The addition of intrathecal horse antitetanus serum (ATS) (Group II) to the routine treatment (Group I) reduced the mortality from 63% to 53% but this was not statistically significant. Following a further addition of parenteral betamethasone to the regimen (Group III) the mortality decreased to 27% which was significantly lower than in Groups I and II. A similar trend in mortality was demonstrated when the severe cases were analysed separately. Groups I and III were comparable in terms of various prognostic factors and the nursing care received but Group II had a higher incidence of unfavourable prognostic factors, which may have obscured the benefit of intrathecal ATS. The combination of parenteral betamethasone and intrathecal ATS seems to be beneficial in the treatment of tetanus.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>6897465</pmid><doi>10.1016/0035-9203(82)90224-3</doi><tpages>4</tpages></addata></record> |
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| ispartof | Transactions of the Royal Society of Tropical Medicine and Hygiene, 1982, Vol.76 (5), p.620-623 |
| issn | 0035-9203 1878-3503 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Adult Betamethasone - therapeutic use Clostridium tetani Female Humans Injections, Spinal Male Tetanus - mortality Tetanus - therapy Tetanus Antitoxin - administration & dosage Tetanus Antitoxin - therapeutic use |
| title | Intrathecal anti-tetanus serum (ATS) and parenteral betamethasone in the treatment of tetanus |
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