Altered degradation of proteins microinjected into senescent human fibroblasts

Ribonuclease A was introduced into the cytoplasm of IMR-90 human diploid fibroblasts by red cell-mediated microinjection. Early passage fibroblasts degraded ribonuclease A with a half-life of approximately 90 h in the presence of 10% fetal calf serum and enhanced the degradative rate 1.6-fold upon s...

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Veröffentlicht in:	The Journal of biological chemistry 1982-12, Vol.257 (24), p.14624-14627
1. Verfasser:	Dice, J F
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line Endoribonucleases - metabolism Erythrocyte Membrane Fibroblasts - metabolism Humans Kinetics Lung Microinjections Proteins - metabolism Ribonuclease, Pancreatic
Online-Zugang:	Volltext
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