Cytogenetics of non-small cell lung cancer: Analysis of consistent non-random abnormalities
Cytogenetic analysis of ten primary non‐small cell lung carcinomas (NSCLC), including five adenocarcinomas (ADC), three squamous cell (SQC), and two large cell (LCC) carcinomas has been carried out in an attempt to determine karyotype changes involved in the early stage of disease. The tumors were a...
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| Veröffentlicht in: | Genes chromosomes & cancer 1990-07, Vol.2 (2), p.116-124 |
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| creator | Lukeis, Robyn Irving, Louis Garson, Margaret Hasthorpe, Suzanne |
| description | Cytogenetic analysis of ten primary non‐small cell lung carcinomas (NSCLC), including five adenocarcinomas (ADC), three squamous cell (SQC), and two large cell (LCC) carcinomas has been carried out in an attempt to determine karyotype changes involved in the early stage of disease. The tumors were all aneuploid and exhibited complex karyotypes with multiple structural and numerical abnormalities. Clonal structural rearrangements were identified and in particular loss of material from the short arm of chromosome 9 had a 90% incidence. This loss was due to non‐reciprocal translocation, deletion, or chromosome loss. Breakpoints were in the region 9q13 to p22. Other chromosome regions that were non‐randomly involved are as follows: 1 cen to p13, 3p, 5q11 to q13, 6p, 6q15 to q27, 7p, 8p, 11q12 to q23, 13p, 14p, 15p, 17p, and 19p. While a primary cytogenetic change in NSCLC has not been identified conclusively, our findings implicate loss of material from 9p as a potentially important event. |
| doi_str_mv | 10.1002/gcc.2870020207 |
| format | Article |
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The tumors were all aneuploid and exhibited complex karyotypes with multiple structural and numerical abnormalities. Clonal structural rearrangements were identified and in particular loss of material from the short arm of chromosome 9 had a 90% incidence. This loss was due to non‐reciprocal translocation, deletion, or chromosome loss. Breakpoints were in the region 9q13 to p22. Other chromosome regions that were non‐randomly involved are as follows: 1 cen to p13, 3p, 5q11 to q13, 6p, 6q15 to q27, 7p, 8p, 11q12 to q23, 13p, 14p, 15p, 17p, and 19p. 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Cancer</addtitle><description>Cytogenetic analysis of ten primary non‐small cell lung carcinomas (NSCLC), including five adenocarcinomas (ADC), three squamous cell (SQC), and two large cell (LCC) carcinomas has been carried out in an attempt to determine karyotype changes involved in the early stage of disease. The tumors were all aneuploid and exhibited complex karyotypes with multiple structural and numerical abnormalities. Clonal structural rearrangements were identified and in particular loss of material from the short arm of chromosome 9 had a 90% incidence. This loss was due to non‐reciprocal translocation, deletion, or chromosome loss. Breakpoints were in the region 9q13 to p22. Other chromosome regions that were non‐randomly involved are as follows: 1 cen to p13, 3p, 5q11 to q13, 6p, 6q15 to q27, 7p, 8p, 11q12 to q23, 13p, 14p, 15p, 17p, and 19p. While a primary cytogenetic change in NSCLC has not been identified conclusively, our findings implicate loss of material from 9p as a potentially important event.</description><subject>Aneuploidy</subject><subject>Carcinoma, Non-Small-Cell Lung - genetics</subject><subject>Chromosome Aberrations</subject><subject>Chromosome Deletion</subject><subject>Chromosome Mapping</subject><subject>Chromosomes, Human, Pair 9 - ultrastructure</subject><subject>Clone Cells - ultrastructure</subject><subject>Humans</subject><subject>Karyotyping</subject><subject>lung</subject><subject>Lung Neoplasms - genetics</subject><subject>Male</subject><subject>Translocation, Genetic</subject><subject>Tumor Cells, Cultured - ultrastructure</subject><issn>1045-2257</issn><issn>1098-2264</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM1LxDAQxYMofl-9CT156zpJmqTxJkVXYVEPiqCHkE3TpdommnTR_e_NuoviSQKTB_N-j-EhdIRhhAHI6cyYESlFkumJDbSLQZY5IbzYXOqCJc3EDtqL8QUAOJVsG20TLAQvil30XC0GP7PODq2JmW8y510ee911mbFpdHM3y4x2xoaz7NzpbhHbb5_xLqnBuuEbCdrVvs_01PmQ6HZobTxAW43uoj1c__vo4fLivrrKJ7fj6-p8khsqQeS6KQpMNeBaMGBYThtuC4pxrbURaQLXVkwJ6LqhRhBZWypA1qUGQbmkmO6jk1XuW_DvcxsH1bdxeb121s-jKoFQXMj_jZhxxkoCyThaGU3wMQbbqLfQ9josFAa1rF2l2tVv7Qk4XifPp72tf-zrntNervYfbWcX_6SpcVX9yc5X7LLuzx9Wh1fFBRVMPd6MFeX3T3e0nChJvwDFDZ1K</recordid><startdate>199007</startdate><enddate>199007</enddate><creator>Lukeis, Robyn</creator><creator>Irving, Louis</creator><creator>Garson, Margaret</creator><creator>Hasthorpe, Suzanne</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T3</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>199007</creationdate><title>Cytogenetics of non-small cell lung cancer: Analysis of consistent non-random abnormalities</title><author>Lukeis, Robyn ; Irving, Louis ; Garson, Margaret ; Hasthorpe, Suzanne</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3907-af4413a01d750519bf6e4311daac71da06ae7b20adf3c729de3709d8a07369313</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Aneuploidy</topic><topic>Carcinoma, Non-Small-Cell Lung - genetics</topic><topic>Chromosome Aberrations</topic><topic>Chromosome Deletion</topic><topic>Chromosome Mapping</topic><topic>Chromosomes, Human, Pair 9 - ultrastructure</topic><topic>Clone Cells - ultrastructure</topic><topic>Humans</topic><topic>Karyotyping</topic><topic>lung</topic><topic>Lung Neoplasms - genetics</topic><topic>Male</topic><topic>Translocation, Genetic</topic><topic>Tumor Cells, Cultured - ultrastructure</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lukeis, Robyn</creatorcontrib><creatorcontrib>Irving, Louis</creatorcontrib><creatorcontrib>Garson, Margaret</creatorcontrib><creatorcontrib>Hasthorpe, Suzanne</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Human Genome Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Genes chromosomes & cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lukeis, Robyn</au><au>Irving, Louis</au><au>Garson, Margaret</au><au>Hasthorpe, Suzanne</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cytogenetics of non-small cell lung cancer: Analysis of consistent non-random abnormalities</atitle><jtitle>Genes chromosomes & cancer</jtitle><addtitle>Genes Chromosom. Cancer</addtitle><date>1990-07</date><risdate>1990</risdate><volume>2</volume><issue>2</issue><spage>116</spage><epage>124</epage><pages>116-124</pages><issn>1045-2257</issn><eissn>1098-2264</eissn><abstract>Cytogenetic analysis of ten primary non‐small cell lung carcinomas (NSCLC), including five adenocarcinomas (ADC), three squamous cell (SQC), and two large cell (LCC) carcinomas has been carried out in an attempt to determine karyotype changes involved in the early stage of disease. The tumors were all aneuploid and exhibited complex karyotypes with multiple structural and numerical abnormalities. Clonal structural rearrangements were identified and in particular loss of material from the short arm of chromosome 9 had a 90% incidence. This loss was due to non‐reciprocal translocation, deletion, or chromosome loss. Breakpoints were in the region 9q13 to p22. 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| ispartof | Genes chromosomes & cancer, 1990-07, Vol.2 (2), p.116-124 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Aneuploidy Carcinoma, Non-Small-Cell Lung - genetics Chromosome Aberrations Chromosome Deletion Chromosome Mapping Chromosomes, Human, Pair 9 - ultrastructure Clone Cells - ultrastructure Humans Karyotyping lung Lung Neoplasms - genetics Male Translocation, Genetic Tumor Cells, Cultured - ultrastructure |
| title | Cytogenetics of non-small cell lung cancer: Analysis of consistent non-random abnormalities |
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