Inotropic Activities of Imidazopyridines
A series of 2‐substituted 1H‐imidazo[4,5‐b]pyridines and the isomeric 1H‐imidazo[4,5‐c]pyridine derivatives has been prepared and evaluated as inotropic agents. The 1H‐imidazo‐[4,5‐b] derivatives were found to be consistently more potent than their isomers in the [4,5‐c] series in isolated guinea pi...
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| Veröffentlicht in: | Archiv der Pharmazie (Weinheim) 1990, Vol.323 (8), p.501-505 |
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| container_title | Archiv der Pharmazie (Weinheim) |
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| creator | Barraclough, Paul Black, James W. Cambridge, David Paul Gerskowitch, V. Hull, Robert A. D. Lyer, Ramachandran Richard King, W. Kneen, Clare O. Nobbs, Malcolm S. Shah, Gita P. Smith, Steven Vine, Susan J. Whiting, Mark V. |
| description | A series of 2‐substituted 1H‐imidazo[4,5‐b]pyridines and the isomeric 1H‐imidazo[4,5‐c]pyridine derivatives has been prepared and evaluated as inotropic agents. The 1H‐imidazo‐[4,5‐b] derivatives were found to be consistently more potent than their isomers in the [4,5‐c] series in isolated guinea pig papillary muscle preparations. Structure‐activity relationships and the species‐dependence of inotropic potencies are discussed.
Inotrope Aktivität von Imidazopyridinen
Es wurde eine Reihe von 2‐substituierten 1H‐Imidazo[4,5‐b]‐pyridinen und der isomeren 1H‐Imidazo[4,5‐c]pyridin‐Derivate hergestellt und als inotrope Agentien evaluiert. Die 1H‐Imidazo‐[4,5‐b]‐Derivate erweisen sich als deutlich wirksamer als ihre Isomere in der [4,5‐c] Reihe am isolierten Papillarmuskel des Meerschweinchens. Es werden die Verhältnisse zwischen Struktur und Aktivität sowie die Artenabhängigkeit der inotropen Wirksamkeit diskutiert. |
| doi_str_mv | 10.1002/ardp.19903230811 |
| format | Article |
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Inotrope Aktivität von Imidazopyridinen
Es wurde eine Reihe von 2‐substituierten 1H‐Imidazo[4,5‐b]‐pyridinen und der isomeren 1H‐Imidazo[4,5‐c]pyridin‐Derivate hergestellt und als inotrope Agentien evaluiert. Die 1H‐Imidazo‐[4,5‐b]‐Derivate erweisen sich als deutlich wirksamer als ihre Isomere in der [4,5‐c] Reihe am isolierten Papillarmuskel des Meerschweinchens. Es werden die Verhältnisse zwischen Struktur und Aktivität sowie die Artenabhängigkeit der inotropen Wirksamkeit diskutiert.</description><identifier>ISSN: 0365-6233</identifier><identifier>EISSN: 1521-4184</identifier><identifier>DOI: 10.1002/ardp.19903230811</identifier><identifier>PMID: 2278516</identifier><identifier>CODEN: ARPMAS</identifier><language>eng</language><publisher>Hannover: WILEY-VCH Verlag</publisher><subject>Anesthesia ; Animals ; Cardiotonic Agents - chemical synthesis ; Chemistry ; Dogs ; Exact sciences and technology ; Female ; Guinea Pigs ; Heterocyclic compounds ; Heterocyclic compounds with several n hetero atoms in the same ring, in separated rings or in fused rings ; Imidazoles - chemical synthesis ; Imidazoles - pharmacology ; In Vitro Techniques ; Male ; Organic chemistry ; Papillary Muscles - drug effects ; Preparations and properties ; Pyridines - chemical synthesis ; Pyridines - pharmacology ; Structure-Activity Relationship</subject><ispartof>Archiv der Pharmazie (Weinheim), 1990, Vol.323 (8), p.501-505</ispartof><rights>Copyright © 1990 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4161-83bc2ac2394e361f5fb888da9b89433252742f7801f15fdd007a4469979fa2bb3</citedby><cites>FETCH-LOGICAL-c4161-83bc2ac2394e361f5fb888da9b89433252742f7801f15fdd007a4469979fa2bb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fardp.19903230811$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fardp.19903230811$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,4024,27923,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19440970$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2278516$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Barraclough, Paul</creatorcontrib><creatorcontrib>Black, James W.</creatorcontrib><creatorcontrib>Cambridge, David</creatorcontrib><creatorcontrib>Paul Gerskowitch, V.</creatorcontrib><creatorcontrib>Hull, Robert A. D.</creatorcontrib><creatorcontrib>Lyer, Ramachandran</creatorcontrib><creatorcontrib>Richard King, W.</creatorcontrib><creatorcontrib>Kneen, Clare O.</creatorcontrib><creatorcontrib>Nobbs, Malcolm S.</creatorcontrib><creatorcontrib>Shah, Gita P.</creatorcontrib><creatorcontrib>Smith, Steven</creatorcontrib><creatorcontrib>Vine, Susan J.</creatorcontrib><creatorcontrib>Whiting, Mark V.</creatorcontrib><title>Inotropic Activities of Imidazopyridines</title><title>Archiv der Pharmazie (Weinheim)</title><addtitle>Arch. Pharm. Pharm. Med. Chem</addtitle><description>A series of 2‐substituted 1H‐imidazo[4,5‐b]pyridines and the isomeric 1H‐imidazo[4,5‐c]pyridine derivatives has been prepared and evaluated as inotropic agents. The 1H‐imidazo‐[4,5‐b] derivatives were found to be consistently more potent than their isomers in the [4,5‐c] series in isolated guinea pig papillary muscle preparations. Structure‐activity relationships and the species‐dependence of inotropic potencies are discussed.
Inotrope Aktivität von Imidazopyridinen
Es wurde eine Reihe von 2‐substituierten 1H‐Imidazo[4,5‐b]‐pyridinen und der isomeren 1H‐Imidazo[4,5‐c]pyridin‐Derivate hergestellt und als inotrope Agentien evaluiert. Die 1H‐Imidazo‐[4,5‐b]‐Derivate erweisen sich als deutlich wirksamer als ihre Isomere in der [4,5‐c] Reihe am isolierten Papillarmuskel des Meerschweinchens. Es werden die Verhältnisse zwischen Struktur und Aktivität sowie die Artenabhängigkeit der inotropen Wirksamkeit diskutiert.</description><subject>Anesthesia</subject><subject>Animals</subject><subject>Cardiotonic Agents - chemical synthesis</subject><subject>Chemistry</subject><subject>Dogs</subject><subject>Exact sciences and technology</subject><subject>Female</subject><subject>Guinea Pigs</subject><subject>Heterocyclic compounds</subject><subject>Heterocyclic compounds with several n hetero atoms in the same ring, in separated rings or in fused rings</subject><subject>Imidazoles - chemical synthesis</subject><subject>Imidazoles - pharmacology</subject><subject>In Vitro Techniques</subject><subject>Male</subject><subject>Organic chemistry</subject><subject>Papillary Muscles - drug effects</subject><subject>Preparations and properties</subject><subject>Pyridines - chemical synthesis</subject><subject>Pyridines - pharmacology</subject><subject>Structure-Activity Relationship</subject><issn>0365-6233</issn><issn>1521-4184</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkDtPwzAUhS0EglLYWZC6gFhSrh-J7YGh4lkBBSEeEovlOLZkSJtgp0D59QS14jEx3eGc79x7D0JbGPoYgOzrUNR9LCVQQkFgvIQ6OCU4YViwZdQBmqVJRihdQ-sxPgEABZKuolVCuEhx1kF7w0nVhKr2pjcwjX_1jbexV7necOwL_VHVs-ALP7FxA604XUa7uZhddHdyfHt4llxcnQ4PBxeJYTjDiaC5IdoQKpmlGXapy4UQhZa5kIxSkhLOiOMCsMOpKwoArhnLpOTSaZLntIt257l1qF6mNjZq7KOxZakntppGJaD9FLhojTA3mlDFGKxTdfBjHWYKg_oqR32Vo36V0yLbi-xpPrbFN7Boo9V3FrqORpcu6Inx8SdXMgaSQ-s7mPvefGln_-5Vg5uj6793JHPex8a-f_M6PKuMU56qh9GpGl3eP56PTu4VoZ-lIIxk</recordid><startdate>1990</startdate><enddate>1990</enddate><creator>Barraclough, Paul</creator><creator>Black, James W.</creator><creator>Cambridge, David</creator><creator>Paul Gerskowitch, V.</creator><creator>Hull, Robert A. D.</creator><creator>Lyer, Ramachandran</creator><creator>Richard King, W.</creator><creator>Kneen, Clare O.</creator><creator>Nobbs, Malcolm S.</creator><creator>Shah, Gita P.</creator><creator>Smith, Steven</creator><creator>Vine, Susan J.</creator><creator>Whiting, Mark V.</creator><general>WILEY-VCH Verlag</general><general>WILEY‐VCH Verlag</general><general>Wiley-VCH</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1990</creationdate><title>Inotropic Activities of Imidazopyridines</title><author>Barraclough, Paul ; Black, James W. ; Cambridge, David ; Paul Gerskowitch, V. ; Hull, Robert A. D. ; Lyer, Ramachandran ; Richard King, W. ; Kneen, Clare O. ; Nobbs, Malcolm S. ; Shah, Gita P. ; Smith, Steven ; Vine, Susan J. ; Whiting, Mark V.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4161-83bc2ac2394e361f5fb888da9b89433252742f7801f15fdd007a4469979fa2bb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Anesthesia</topic><topic>Animals</topic><topic>Cardiotonic Agents - chemical synthesis</topic><topic>Chemistry</topic><topic>Dogs</topic><topic>Exact sciences and technology</topic><topic>Female</topic><topic>Guinea Pigs</topic><topic>Heterocyclic compounds</topic><topic>Heterocyclic compounds with several n hetero atoms in the same ring, in separated rings or in fused rings</topic><topic>Imidazoles - chemical synthesis</topic><topic>Imidazoles - pharmacology</topic><topic>In Vitro Techniques</topic><topic>Male</topic><topic>Organic chemistry</topic><topic>Papillary Muscles - drug effects</topic><topic>Preparations and properties</topic><topic>Pyridines - chemical synthesis</topic><topic>Pyridines - pharmacology</topic><topic>Structure-Activity Relationship</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Barraclough, Paul</creatorcontrib><creatorcontrib>Black, James W.</creatorcontrib><creatorcontrib>Cambridge, David</creatorcontrib><creatorcontrib>Paul Gerskowitch, V.</creatorcontrib><creatorcontrib>Hull, Robert A. D.</creatorcontrib><creatorcontrib>Lyer, Ramachandran</creatorcontrib><creatorcontrib>Richard King, W.</creatorcontrib><creatorcontrib>Kneen, Clare O.</creatorcontrib><creatorcontrib>Nobbs, Malcolm S.</creatorcontrib><creatorcontrib>Shah, Gita P.</creatorcontrib><creatorcontrib>Smith, Steven</creatorcontrib><creatorcontrib>Vine, Susan J.</creatorcontrib><creatorcontrib>Whiting, Mark V.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Archiv der Pharmazie (Weinheim)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Barraclough, Paul</au><au>Black, James W.</au><au>Cambridge, David</au><au>Paul Gerskowitch, V.</au><au>Hull, Robert A. D.</au><au>Lyer, Ramachandran</au><au>Richard King, W.</au><au>Kneen, Clare O.</au><au>Nobbs, Malcolm S.</au><au>Shah, Gita P.</au><au>Smith, Steven</au><au>Vine, Susan J.</au><au>Whiting, Mark V.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inotropic Activities of Imidazopyridines</atitle><jtitle>Archiv der Pharmazie (Weinheim)</jtitle><addtitle>Arch. Pharm. Pharm. Med. Chem</addtitle><date>1990</date><risdate>1990</risdate><volume>323</volume><issue>8</issue><spage>501</spage><epage>505</epage><pages>501-505</pages><issn>0365-6233</issn><eissn>1521-4184</eissn><coden>ARPMAS</coden><abstract>A series of 2‐substituted 1H‐imidazo[4,5‐b]pyridines and the isomeric 1H‐imidazo[4,5‐c]pyridine derivatives has been prepared and evaluated as inotropic agents. The 1H‐imidazo‐[4,5‐b] derivatives were found to be consistently more potent than their isomers in the [4,5‐c] series in isolated guinea pig papillary muscle preparations. Structure‐activity relationships and the species‐dependence of inotropic potencies are discussed.
Inotrope Aktivität von Imidazopyridinen
Es wurde eine Reihe von 2‐substituierten 1H‐Imidazo[4,5‐b]‐pyridinen und der isomeren 1H‐Imidazo[4,5‐c]pyridin‐Derivate hergestellt und als inotrope Agentien evaluiert. Die 1H‐Imidazo‐[4,5‐b]‐Derivate erweisen sich als deutlich wirksamer als ihre Isomere in der [4,5‐c] Reihe am isolierten Papillarmuskel des Meerschweinchens. Es werden die Verhältnisse zwischen Struktur und Aktivität sowie die Artenabhängigkeit der inotropen Wirksamkeit diskutiert.</abstract><cop>Hannover</cop><pub>WILEY-VCH Verlag</pub><pmid>2278516</pmid><doi>10.1002/ardp.19903230811</doi><tpages>5</tpages></addata></record> |
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| ispartof | Archiv der Pharmazie (Weinheim), 1990, Vol.323 (8), p.501-505 |
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| language | eng |
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| subjects | Anesthesia Animals Cardiotonic Agents - chemical synthesis Chemistry Dogs Exact sciences and technology Female Guinea Pigs Heterocyclic compounds Heterocyclic compounds with several n hetero atoms in the same ring, in separated rings or in fused rings Imidazoles - chemical synthesis Imidazoles - pharmacology In Vitro Techniques Male Organic chemistry Papillary Muscles - drug effects Preparations and properties Pyridines - chemical synthesis Pyridines - pharmacology Structure-Activity Relationship |
| title | Inotropic Activities of Imidazopyridines |
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