Effect of pro-atrial natriuretic peptides 1–30, 31–67 and 99–126 on angiotensin II-stimulated aldosterone production in calf adrenal cells
Pro-atrial natriuretic peptide (Pro-ANP) is a 126 amino acid peptide from which atrial natriuretic peptide (ANP) (99–126 amino acid) is derived. ANP has potent diuretic, natriuretic and vasodilatory properties. ANP is also a potent direct and indirect inhibitor of aldosterone secretion. The N-termin...
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| Veröffentlicht in: | The Journal of steroid biochemistry and molecular biology 1990-11, Vol.37 (4), p.617-619 |
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| creator | Denker, Paul S. Vesely, David L. Gómez-Sánchez, Celso E. |
| description | Pro-atrial natriuretic peptide (Pro-ANP) is a 126 amino acid peptide from which atrial natriuretic peptide (ANP) (99–126 amino acid) is derived. ANP has potent diuretic, natriuretic and vasodilatory properties. ANP is also a potent direct and indirect inhibitor of aldosterone secretion. The N-terminus of the ANP prohormone containing the peptides 1–30 and 31–67 have been demonstrated to have diuretic, natriuretic and vasodilatory properties.
Dispersed calf zona glomerulosa cells were incubated with angiotensin II (A-II) and increasing concentrations of ANP, ProANP 1–30 and 31–67 to determine if their reported natriuretic activity was mediated through suppression of aldosterone secretion. ANP as reported by many investigators produced a dose-dependent and potent inhibition of A-II-mediated aldosterone secretion. The Pro-ANP 1–30 and 31–67 did not affect A-II-stimulated aldosterone secretion at any of the doses tested. This study shows that the reported natriuretic effect of the fragments is not mediated by inhibition of aldosterone secretion. |
| doi_str_mv | 10.1016/0960-0760(90)90410-M |
| format | Article |
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Dispersed calf zona glomerulosa cells were incubated with angiotensin II (A-II) and increasing concentrations of ANP, ProANP 1–30 and 31–67 to determine if their reported natriuretic activity was mediated through suppression of aldosterone secretion. ANP as reported by many investigators produced a dose-dependent and potent inhibition of A-II-mediated aldosterone secretion. The Pro-ANP 1–30 and 31–67 did not affect A-II-stimulated aldosterone secretion at any of the doses tested. This study shows that the reported natriuretic effect of the fragments is not mediated by inhibition of aldosterone secretion.</description><identifier>ISSN: 0960-0760</identifier><identifier>EISSN: 1879-1220</identifier><identifier>DOI: 10.1016/0960-0760(90)90410-M</identifier><identifier>PMID: 2149056</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Adrenals. Interrenals ; Adrenocortical hormones. Regulation ; Aldosterone - biosynthesis ; Aldosterone - metabolism ; Angiotensin II - antagonists & inhibitors ; Angiotensin II - pharmacology ; Animals ; Atrial Natriuretic Factor - pharmacology ; Biological and medical sciences ; Cattle ; Fundamental and applied biological sciences. Psychology ; Peptide Fragments - pharmacology ; Protein Precursors - pharmacology ; Vertebrates: endocrinology ; Zona Glomerulosa - drug effects ; Zona Glomerulosa - metabolism</subject><ispartof>The Journal of steroid biochemistry and molecular biology, 1990-11, Vol.37 (4), p.617-619</ispartof><rights>1990</rights><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c399t-6b2dbef7aac0909ef46d8248df44027b14d05e302aab1474545cd4c225a1a57d3</citedby><cites>FETCH-LOGICAL-c399t-6b2dbef7aac0909ef46d8248df44027b14d05e302aab1474545cd4c225a1a57d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0960-0760(90)90410-M$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,778,782,3539,27911,27912,45982</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19653440$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2149056$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Denker, Paul S.</creatorcontrib><creatorcontrib>Vesely, David L.</creatorcontrib><creatorcontrib>Gómez-Sánchez, Celso E.</creatorcontrib><title>Effect of pro-atrial natriuretic peptides 1–30, 31–67 and 99–126 on angiotensin II-stimulated aldosterone production in calf adrenal cells</title><title>The Journal of steroid biochemistry and molecular biology</title><addtitle>J Steroid Biochem Mol Biol</addtitle><description>Pro-atrial natriuretic peptide (Pro-ANP) is a 126 amino acid peptide from which atrial natriuretic peptide (ANP) (99–126 amino acid) is derived. ANP has potent diuretic, natriuretic and vasodilatory properties. ANP is also a potent direct and indirect inhibitor of aldosterone secretion. The N-terminus of the ANP prohormone containing the peptides 1–30 and 31–67 have been demonstrated to have diuretic, natriuretic and vasodilatory properties.
Dispersed calf zona glomerulosa cells were incubated with angiotensin II (A-II) and increasing concentrations of ANP, ProANP 1–30 and 31–67 to determine if their reported natriuretic activity was mediated through suppression of aldosterone secretion. ANP as reported by many investigators produced a dose-dependent and potent inhibition of A-II-mediated aldosterone secretion. The Pro-ANP 1–30 and 31–67 did not affect A-II-stimulated aldosterone secretion at any of the doses tested. This study shows that the reported natriuretic effect of the fragments is not mediated by inhibition of aldosterone secretion.</description><subject>Adrenals. Interrenals</subject><subject>Adrenocortical hormones. Regulation</subject><subject>Aldosterone - biosynthesis</subject><subject>Aldosterone - metabolism</subject><subject>Angiotensin II - antagonists & inhibitors</subject><subject>Angiotensin II - pharmacology</subject><subject>Animals</subject><subject>Atrial Natriuretic Factor - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Cattle</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Peptide Fragments - pharmacology</subject><subject>Protein Precursors - pharmacology</subject><subject>Vertebrates: endocrinology</subject><subject>Zona Glomerulosa - drug effects</subject><subject>Zona Glomerulosa - metabolism</subject><issn>0960-0760</issn><issn>1879-1220</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc2KFDEQx4Mo67j6Bgq5KAq2VtLppHNZkGXVgV286DlkkmqJ9CRjkha8-QiCb-iTmGaG9aYQqCrqVx-pPyGPGbxiwORr0BI6UBKea3ihQTDobu6QDRuV7hjncJdsbpH75EEpXwCg75k6I2ecCQ2D3JCfV9OErtI00UNOna052JnG1S4Za3D0gIcaPBbKfv_41cNL2q-OVNRGT7VuPuOSptjizyFVjCVEut12pYb9MtuKntrZp1Ixp4jrFL-4GlpB45ydJ2p9xtimOpzn8pDcm-xc8NHJnpNPb68-Xr7vrj-8216-ue5cr3Xt5I77HU7KWgcaNE5C-pGL0U9CAFc7JjwM2AO3tvlKDGJwXjjOB8vsoHx_Tp4d-7aFvi5YqtmHsm5gI6almBE414rr_4JsGLUCPjRQHEGXUykZJ3PIYW_zd8PArIqZVQ6zymH0-ppi5qaVPTn1X3Z79LdFJ4la_ukpb8t6rmyjC-Vvby2Hvv25cRdHDtvVvgXMpriA0aEPuSlsfAr_XuQP62K0Rw</recordid><startdate>19901130</startdate><enddate>19901130</enddate><creator>Denker, Paul S.</creator><creator>Vesely, David L.</creator><creator>Gómez-Sánchez, Celso E.</creator><general>Elsevier Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19901130</creationdate><title>Effect of pro-atrial natriuretic peptides 1–30, 31–67 and 99–126 on angiotensin II-stimulated aldosterone production in calf adrenal cells</title><author>Denker, Paul S. ; Vesely, David L. ; Gómez-Sánchez, Celso E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c399t-6b2dbef7aac0909ef46d8248df44027b14d05e302aab1474545cd4c225a1a57d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Adrenals. Interrenals</topic><topic>Adrenocortical hormones. Regulation</topic><topic>Aldosterone - biosynthesis</topic><topic>Aldosterone - metabolism</topic><topic>Angiotensin II - antagonists & inhibitors</topic><topic>Angiotensin II - pharmacology</topic><topic>Animals</topic><topic>Atrial Natriuretic Factor - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Cattle</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Peptide Fragments - pharmacology</topic><topic>Protein Precursors - pharmacology</topic><topic>Vertebrates: endocrinology</topic><topic>Zona Glomerulosa - drug effects</topic><topic>Zona Glomerulosa - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Denker, Paul S.</creatorcontrib><creatorcontrib>Vesely, David L.</creatorcontrib><creatorcontrib>Gómez-Sánchez, Celso E.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of steroid biochemistry and molecular biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Denker, Paul S.</au><au>Vesely, David L.</au><au>Gómez-Sánchez, Celso E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of pro-atrial natriuretic peptides 1–30, 31–67 and 99–126 on angiotensin II-stimulated aldosterone production in calf adrenal cells</atitle><jtitle>The Journal of steroid biochemistry and molecular biology</jtitle><addtitle>J Steroid Biochem Mol Biol</addtitle><date>1990-11-30</date><risdate>1990</risdate><volume>37</volume><issue>4</issue><spage>617</spage><epage>619</epage><pages>617-619</pages><issn>0960-0760</issn><eissn>1879-1220</eissn><abstract>Pro-atrial natriuretic peptide (Pro-ANP) is a 126 amino acid peptide from which atrial natriuretic peptide (ANP) (99–126 amino acid) is derived. ANP has potent diuretic, natriuretic and vasodilatory properties. ANP is also a potent direct and indirect inhibitor of aldosterone secretion. The N-terminus of the ANP prohormone containing the peptides 1–30 and 31–67 have been demonstrated to have diuretic, natriuretic and vasodilatory properties.
Dispersed calf zona glomerulosa cells were incubated with angiotensin II (A-II) and increasing concentrations of ANP, ProANP 1–30 and 31–67 to determine if their reported natriuretic activity was mediated through suppression of aldosterone secretion. ANP as reported by many investigators produced a dose-dependent and potent inhibition of A-II-mediated aldosterone secretion. The Pro-ANP 1–30 and 31–67 did not affect A-II-stimulated aldosterone secretion at any of the doses tested. This study shows that the reported natriuretic effect of the fragments is not mediated by inhibition of aldosterone secretion.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>2149056</pmid><doi>10.1016/0960-0760(90)90410-M</doi><tpages>3</tpages></addata></record> |
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| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE |
| subjects | Adrenals. Interrenals Adrenocortical hormones. Regulation Aldosterone - biosynthesis Aldosterone - metabolism Angiotensin II - antagonists & inhibitors Angiotensin II - pharmacology Animals Atrial Natriuretic Factor - pharmacology Biological and medical sciences Cattle Fundamental and applied biological sciences. Psychology Peptide Fragments - pharmacology Protein Precursors - pharmacology Vertebrates: endocrinology Zona Glomerulosa - drug effects Zona Glomerulosa - metabolism |
| title | Effect of pro-atrial natriuretic peptides 1–30, 31–67 and 99–126 on angiotensin II-stimulated aldosterone production in calf adrenal cells |
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