Severity of glomerulonephritis induced in different strains of suckling mice by infection with lymphocytic choriomeningitis virus: Correlation with amounts of endogenous interferon and circulating immune complexes
Renal lesions due to neonatal infection with lymphocytic choriomeningitis virus were studied in three different strains of mice known to produce different amounts of viral interferon. Very severe ultrastructural lesions similar to those induced by exogenous interferon were found as early as day 8 in...
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| Veröffentlicht in: | The Journal of pathology 1982-12, Vol.138 (4), p.325-336 |
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| container_title | The Journal of pathology |
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| creator | Woodrow, D. Ronco, P. Riviere, Y. Moss, J. Gresser, I. Guillon, J. C. Morel-Maroger, L. Sloper, J. C. Verroust, P. |
| description | Renal lesions due to neonatal infection with lymphocytic choriomeningitis virus were studied in three different strains of mice known to produce different amounts of viral interferon. Very severe ultrastructural lesions similar to those induced by exogenous interferon were found as early as day 8 in C3H mice which produced the highest amount of interferon. Further studies could not be performed in these mice since all died by day 14. Balb/c mice produced the lowest amount of interferon and had very mild ultrastructural lesions. An intermediate pattern was found in Swiss mice. After 30 days of infection, severe immune complex type glomerulonephritis detectable by light microscopy and immunofluorescence was observed in Swiss mice whereas mild lesions only were found in Balb/c mice. Circulating immune complexes were present in both strains but in greater amounts in Swiss than Balb/c mice. These results suggest that two factors at least are important in the development of glomerulonephritis: interferon produced early in life and the load of circulating immune complexes. |
| doi_str_mv | 10.1002/path.1711380404 |
| format | Article |
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C. ; Morel-Maroger, L. ; Sloper, J. C. ; Verroust, P.</creator><creatorcontrib>Woodrow, D. ; Ronco, P. ; Riviere, Y. ; Moss, J. ; Gresser, I. ; Guillon, J. C. ; Morel-Maroger, L. ; Sloper, J. C. ; Verroust, P.</creatorcontrib><description>Renal lesions due to neonatal infection with lymphocytic choriomeningitis virus were studied in three different strains of mice known to produce different amounts of viral interferon. Very severe ultrastructural lesions similar to those induced by exogenous interferon were found as early as day 8 in C3H mice which produced the highest amount of interferon. Further studies could not be performed in these mice since all died by day 14. Balb/c mice produced the lowest amount of interferon and had very mild ultrastructural lesions. An intermediate pattern was found in Swiss mice. After 30 days of infection, severe immune complex type glomerulonephritis detectable by light microscopy and immunofluorescence was observed in Swiss mice whereas mild lesions only were found in Balb/c mice. Circulating immune complexes were present in both strains but in greater amounts in Swiss than Balb/c mice. These results suggest that two factors at least are important in the development of glomerulonephritis: interferon produced early in life and the load of circulating immune complexes.</description><identifier>ISSN: 0022-3417</identifier><identifier>EISSN: 1096-9896</identifier><identifier>DOI: 10.1002/path.1711380404</identifier><identifier>PMID: 6184462</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Animals ; Animals, Suckling ; Antigen-Antibody Complex - analysis ; Glomerulonephritis - etiology ; Glomerulonephritis - immunology ; Glomerulonephritis - pathology ; Immunoglobulin G - analysis ; Interferons - blood ; Kidney Glomerulus - ultrastructure ; Lymphocytic Choriomeningitis - complications ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C3H ; Microscopy, Electron ; Time Factors</subject><ispartof>The Journal of pathology, 1982-12, Vol.138 (4), p.325-336</ispartof><rights>Copyright © 1982 The Pathological Society of Great Britain and Ireland</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3824-fff39d8a04fcfaae9085e045530b5da21d6a218b3fa6cfca0cb9433c085281223</citedby><cites>FETCH-LOGICAL-c3824-fff39d8a04fcfaae9085e045530b5da21d6a218b3fa6cfca0cb9433c085281223</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fpath.1711380404$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fpath.1711380404$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6184462$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Woodrow, D.</creatorcontrib><creatorcontrib>Ronco, P.</creatorcontrib><creatorcontrib>Riviere, Y.</creatorcontrib><creatorcontrib>Moss, J.</creatorcontrib><creatorcontrib>Gresser, I.</creatorcontrib><creatorcontrib>Guillon, J. C.</creatorcontrib><creatorcontrib>Morel-Maroger, L.</creatorcontrib><creatorcontrib>Sloper, J. C.</creatorcontrib><creatorcontrib>Verroust, P.</creatorcontrib><title>Severity of glomerulonephritis induced in different strains of suckling mice by infection with lymphocytic choriomeningitis virus: Correlation with amounts of endogenous interferon and circulating immune complexes</title><title>The Journal of pathology</title><addtitle>J. Pathol</addtitle><description>Renal lesions due to neonatal infection with lymphocytic choriomeningitis virus were studied in three different strains of mice known to produce different amounts of viral interferon. Very severe ultrastructural lesions similar to those induced by exogenous interferon were found as early as day 8 in C3H mice which produced the highest amount of interferon. Further studies could not be performed in these mice since all died by day 14. Balb/c mice produced the lowest amount of interferon and had very mild ultrastructural lesions. An intermediate pattern was found in Swiss mice. After 30 days of infection, severe immune complex type glomerulonephritis detectable by light microscopy and immunofluorescence was observed in Swiss mice whereas mild lesions only were found in Balb/c mice. Circulating immune complexes were present in both strains but in greater amounts in Swiss than Balb/c mice. These results suggest that two factors at least are important in the development of glomerulonephritis: interferon produced early in life and the load of circulating immune complexes.</description><subject>Animals</subject><subject>Animals, Suckling</subject><subject>Antigen-Antibody Complex - analysis</subject><subject>Glomerulonephritis - etiology</subject><subject>Glomerulonephritis - immunology</subject><subject>Glomerulonephritis - pathology</subject><subject>Immunoglobulin G - analysis</subject><subject>Interferons - blood</subject><subject>Kidney Glomerulus - ultrastructure</subject><subject>Lymphocytic Choriomeningitis - complications</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Mice, Inbred C3H</subject><subject>Microscopy, Electron</subject><subject>Time Factors</subject><issn>0022-3417</issn><issn>1096-9896</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1982</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFv1DAQhS0EKkvhzAnJJ25p7djJJnCqVtAiVYDEIqReLMcZb0wTO7Wdtvmh_B-c7qoVJy4eyfO9N6N5CL2l5IQSkp-OMnYndE0pqwgn_BlaUVKXWV3V5XO0SkSeMU7XL9GrEH4TQuq6KI7QUUkrzst8hf78gFvwJs7Yabzr3QB-6p2FsUufJmBj20lBmypujdbgwUYcopfGhkUSJnXdG7vDg1GAmzmBGlQ0zuI7Ezvcz8PYOTVHo7DqnDdpgk38g_mt8VP4gDfOe-jlk0gObrLxwR9s63Zg3bSsEsGnDRIlbYuV8WpaVGm4GYbJAlZuGHu4h_AavdCyD_DmUI_Rz8-ftpuL7PLb-ZfN2WWmWJXzTGvN6raShGulpYSaVAUQXhSMNEUrc9qW6akapmWptJJENTVnTCUsr2ies2P0fu87enczQYhiMEFB30sLaWVRpfunbOoEnu5B5V0IHrQYvRmknwUlYglSLEGKpyCT4t3BemoGaB_5Q3Kp_3HfvzM9zP-zE9_Pthf_uGd7tQkR7h_V0l-Lcs3Whfj19VxQtibb_OpKcPYXIlnCrw</recordid><startdate>198212</startdate><enddate>198212</enddate><creator>Woodrow, D.</creator><creator>Ronco, P.</creator><creator>Riviere, Y.</creator><creator>Moss, J.</creator><creator>Gresser, I.</creator><creator>Guillon, J. C.</creator><creator>Morel-Maroger, L.</creator><creator>Sloper, J. C.</creator><creator>Verroust, P.</creator><general>John Wiley & Sons, Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198212</creationdate><title>Severity of glomerulonephritis induced in different strains of suckling mice by infection with lymphocytic choriomeningitis virus: Correlation with amounts of endogenous interferon and circulating immune complexes</title><author>Woodrow, D. ; Ronco, P. ; Riviere, Y. ; Moss, J. ; Gresser, I. ; Guillon, J. C. ; Morel-Maroger, L. ; Sloper, J. C. ; Verroust, P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3824-fff39d8a04fcfaae9085e045530b5da21d6a218b3fa6cfca0cb9433c085281223</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1982</creationdate><topic>Animals</topic><topic>Animals, Suckling</topic><topic>Antigen-Antibody Complex - analysis</topic><topic>Glomerulonephritis - etiology</topic><topic>Glomerulonephritis - immunology</topic><topic>Glomerulonephritis - pathology</topic><topic>Immunoglobulin G - analysis</topic><topic>Interferons - blood</topic><topic>Kidney Glomerulus - ultrastructure</topic><topic>Lymphocytic Choriomeningitis - complications</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Mice, Inbred C3H</topic><topic>Microscopy, Electron</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Woodrow, D.</creatorcontrib><creatorcontrib>Ronco, P.</creatorcontrib><creatorcontrib>Riviere, Y.</creatorcontrib><creatorcontrib>Moss, J.</creatorcontrib><creatorcontrib>Gresser, I.</creatorcontrib><creatorcontrib>Guillon, J. 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C.</au><au>Verroust, P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Severity of glomerulonephritis induced in different strains of suckling mice by infection with lymphocytic choriomeningitis virus: Correlation with amounts of endogenous interferon and circulating immune complexes</atitle><jtitle>The Journal of pathology</jtitle><addtitle>J. Pathol</addtitle><date>1982-12</date><risdate>1982</risdate><volume>138</volume><issue>4</issue><spage>325</spage><epage>336</epage><pages>325-336</pages><issn>0022-3417</issn><eissn>1096-9896</eissn><abstract>Renal lesions due to neonatal infection with lymphocytic choriomeningitis virus were studied in three different strains of mice known to produce different amounts of viral interferon. Very severe ultrastructural lesions similar to those induced by exogenous interferon were found as early as day 8 in C3H mice which produced the highest amount of interferon. Further studies could not be performed in these mice since all died by day 14. Balb/c mice produced the lowest amount of interferon and had very mild ultrastructural lesions. An intermediate pattern was found in Swiss mice. After 30 days of infection, severe immune complex type glomerulonephritis detectable by light microscopy and immunofluorescence was observed in Swiss mice whereas mild lesions only were found in Balb/c mice. Circulating immune complexes were present in both strains but in greater amounts in Swiss than Balb/c mice. These results suggest that two factors at least are important in the development of glomerulonephritis: interferon produced early in life and the load of circulating immune complexes.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>6184462</pmid><doi>10.1002/path.1711380404</doi><tpages>12</tpages></addata></record> |
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| ispartof | The Journal of pathology, 1982-12, Vol.138 (4), p.325-336 |
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| source | Wiley Online Library - AutoHoldings Journals; MEDLINE |
| subjects | Animals Animals, Suckling Antigen-Antibody Complex - analysis Glomerulonephritis - etiology Glomerulonephritis - immunology Glomerulonephritis - pathology Immunoglobulin G - analysis Interferons - blood Kidney Glomerulus - ultrastructure Lymphocytic Choriomeningitis - complications Mice Mice, Inbred BALB C Mice, Inbred C3H Microscopy, Electron Time Factors |
| title | Severity of glomerulonephritis induced in different strains of suckling mice by infection with lymphocytic choriomeningitis virus: Correlation with amounts of endogenous interferon and circulating immune complexes |
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