Effect of Nifedipine on Blood Pressure and on Intracellular Calcium in Arterial Hypertension
In 13 patients with essential and renal hypertension, the influence of nifedipine on the intracellular free Ca concentration was tested. Measurements of free Ca were performed with a Ca-selective electrode. The patients were additionally treated with a conventional antihypertensive combination thera...
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| Veröffentlicht in: | Journal of cardiovascular pharmacology 1982, Vol.4 Suppl 3 (Supplement 3), p.S306-S306 |
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| container_issue | Supplement 3 |
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| container_title | Journal of cardiovascular pharmacology |
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| creator | Zidek, W Losse, H Vetter, H |
| description | In 13 patients with essential and renal hypertension, the influence of nifedipine on the intracellular free Ca concentration was tested. Measurements of free Ca were performed with a Ca-selective electrode. The patients were additionally treated with a conventional antihypertensive combination therapy, by which the blood pressure could not be lowered satisfactorily. Under treatment with 30–60 mg of nifedipine daily, blood pressure was lowered from 192 ± 23/95 ± 15 mm Hg to 147 ± 20/83 ± 16 mm Hg. The intracellular Caactivity fell from 7,115 ± 14,139 to 1,886 ± 3,748 μmol/L (p < 0.05). The decrease in intracellular Ca correlated very well with the initial value of Ca activity (r = 0.966)furthermore, a relationship was found with the serum creatinine level (r = 0.48). On the other hand, there was no correlation with the decrease in blood pressure. In the lower dose range, nifedipine did not elicit a clear reduction in intracellular Ca. The results show that intracellular Ca activity can be influenced by Caantagonists, but that there is no direct relationship between intracellular free calcium and blood pressure. |
| doi_str_mv | 10.1097/00005344-198200433-00009 |
| format | Article |
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Measurements of free Ca were performed with a Ca-selective electrode. The patients were additionally treated with a conventional antihypertensive combination therapy, by which the blood pressure could not be lowered satisfactorily. Under treatment with 30–60 mg of nifedipine daily, blood pressure was lowered from 192 ± 23/95 ± 15 mm Hg to 147 ± 20/83 ± 16 mm Hg. The intracellular Caactivity fell from 7,115 ± 14,139 to 1,886 ± 3,748 μmol/L (p < 0.05). The decrease in intracellular Ca correlated very well with the initial value of Ca activity (r = 0.966)furthermore, a relationship was found with the serum creatinine level (r = 0.48). On the other hand, there was no correlation with the decrease in blood pressure. In the lower dose range, nifedipine did not elicit a clear reduction in intracellular Ca. The results show that intracellular Ca activity can be influenced by Caantagonists, but that there is no direct relationship between intracellular free calcium and blood pressure.</description><identifier>ISSN: 0160-2446</identifier><identifier>EISSN: 1533-4023</identifier><identifier>DOI: 10.1097/00005344-198200433-00009</identifier><identifier>PMID: 6184558</identifier><language>eng</language><publisher>United States: Lippincott-Raven Publishers</publisher><subject>Adult ; Aged ; Blood Pressure - drug effects ; Calcium - metabolism ; Calcium Channel Blockers - pharmacology ; Creatinine - blood ; Erythrocytes - metabolism ; Female ; Humans ; Hypertension - metabolism ; Hypertension - physiopathology ; Intracellular Fluid - metabolism ; Male ; Middle Aged ; Nifedipine - pharmacology ; Pyridines - pharmacology</subject><ispartof>Journal of cardiovascular pharmacology, 1982, Vol.4 Suppl 3 (Supplement 3), p.S306-S306</ispartof><rights>Lippincott-Raven Publishers.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4059-7746dc4dc02175fb11b4be268e58ed3a975cb0d130e2899f613f82eb39fc385a3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&NEWS=n&CSC=Y&PAGE=fulltext&D=ovft&AN=00005344-198200433-00009$$EHTML$$P50$$Gwolterskluwer$$H</linktohtml><link.rule.ids>314,776,780,4009,4594,27902,27903,27904,65209</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6184558$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zidek, W</creatorcontrib><creatorcontrib>Losse, H</creatorcontrib><creatorcontrib>Vetter, H</creatorcontrib><title>Effect of Nifedipine on Blood Pressure and on Intracellular Calcium in Arterial Hypertension</title><title>Journal of cardiovascular pharmacology</title><addtitle>J Cardiovasc Pharmacol</addtitle><description>In 13 patients with essential and renal hypertension, the influence of nifedipine on the intracellular free Ca concentration was tested. Measurements of free Ca were performed with a Ca-selective electrode. The patients were additionally treated with a conventional antihypertensive combination therapy, by which the blood pressure could not be lowered satisfactorily. Under treatment with 30–60 mg of nifedipine daily, blood pressure was lowered from 192 ± 23/95 ± 15 mm Hg to 147 ± 20/83 ± 16 mm Hg. The intracellular Caactivity fell from 7,115 ± 14,139 to 1,886 ± 3,748 μmol/L (p < 0.05). The decrease in intracellular Ca correlated very well with the initial value of Ca activity (r = 0.966)furthermore, a relationship was found with the serum creatinine level (r = 0.48). On the other hand, there was no correlation with the decrease in blood pressure. In the lower dose range, nifedipine did not elicit a clear reduction in intracellular Ca. The results show that intracellular Ca activity can be influenced by Caantagonists, but that there is no direct relationship between intracellular free calcium and blood pressure.</description><subject>Adult</subject><subject>Aged</subject><subject>Blood Pressure - drug effects</subject><subject>Calcium - metabolism</subject><subject>Calcium Channel Blockers - pharmacology</subject><subject>Creatinine - blood</subject><subject>Erythrocytes - metabolism</subject><subject>Female</subject><subject>Humans</subject><subject>Hypertension - metabolism</subject><subject>Hypertension - physiopathology</subject><subject>Intracellular Fluid - metabolism</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Nifedipine - pharmacology</subject><subject>Pyridines - pharmacology</subject><issn>0160-2446</issn><issn>1533-4023</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1982</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU1P3DAQhq2KChban1DJJ24p46_EPtIVFCREe2hvlSzHGQsXb7y1EyH-fbPswo25ePzOvJ7RY0Iog68MTHcBSyghZcOM5gBSiGYnmQ9kxdRykcDFEVkBa6HhUrYn5LTWvwBMqq49Jsct01IpvSJ_rkJAP9Ec6H0MOMRtHJHmkX5LOQ_0Z8Fa54LUjcNOvR2n4jymNCdX6NolH-cNjSO9LBOW6BK9ed7iko815vET-Rhcqvj5cJ6R39dXv9Y3zd2P77fry7vGS1Cm6TrZDl4OHjjrVOgZ62WPvNWoNA7CmU75HgYmALk2JrRMBM2xFyZ4oZUTZ-R8_-625H8z1sluYt1t6UbMc7UaOO_AsKVR7xt9ybUWDHZb4saVZ8vA7sDaV7D2DeyLZBbrl8OMud_g8GY8kFzqcl9_ymlBUR_T_ITFPqBL04N977_Ef3W7gug</recordid><startdate>1982</startdate><enddate>1982</enddate><creator>Zidek, W</creator><creator>Losse, H</creator><creator>Vetter, H</creator><general>Lippincott-Raven Publishers</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1982</creationdate><title>Effect of Nifedipine on Blood Pressure and on Intracellular Calcium in Arterial Hypertension</title><author>Zidek, W ; Losse, H ; Vetter, H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4059-7746dc4dc02175fb11b4be268e58ed3a975cb0d130e2899f613f82eb39fc385a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1982</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Blood Pressure - drug effects</topic><topic>Calcium - metabolism</topic><topic>Calcium Channel Blockers - pharmacology</topic><topic>Creatinine - blood</topic><topic>Erythrocytes - metabolism</topic><topic>Female</topic><topic>Humans</topic><topic>Hypertension - metabolism</topic><topic>Hypertension - physiopathology</topic><topic>Intracellular Fluid - metabolism</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Nifedipine - pharmacology</topic><topic>Pyridines - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zidek, W</creatorcontrib><creatorcontrib>Losse, H</creatorcontrib><creatorcontrib>Vetter, H</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cardiovascular pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zidek, W</au><au>Losse, H</au><au>Vetter, H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Nifedipine on Blood Pressure and on Intracellular Calcium in Arterial Hypertension</atitle><jtitle>Journal of cardiovascular pharmacology</jtitle><addtitle>J Cardiovasc Pharmacol</addtitle><date>1982</date><risdate>1982</risdate><volume>4 Suppl 3</volume><issue>Supplement 3</issue><spage>S306</spage><epage>S306</epage><pages>S306-S306</pages><issn>0160-2446</issn><eissn>1533-4023</eissn><abstract>In 13 patients with essential and renal hypertension, the influence of nifedipine on the intracellular free Ca concentration was tested. Measurements of free Ca were performed with a Ca-selective electrode. The patients were additionally treated with a conventional antihypertensive combination therapy, by which the blood pressure could not be lowered satisfactorily. Under treatment with 30–60 mg of nifedipine daily, blood pressure was lowered from 192 ± 23/95 ± 15 mm Hg to 147 ± 20/83 ± 16 mm Hg. The intracellular Caactivity fell from 7,115 ± 14,139 to 1,886 ± 3,748 μmol/L (p < 0.05). The decrease in intracellular Ca correlated very well with the initial value of Ca activity (r = 0.966)furthermore, a relationship was found with the serum creatinine level (r = 0.48). On the other hand, there was no correlation with the decrease in blood pressure. In the lower dose range, nifedipine did not elicit a clear reduction in intracellular Ca. The results show that intracellular Ca activity can be influenced by Caantagonists, but that there is no direct relationship between intracellular free calcium and blood pressure.</abstract><cop>United States</cop><pub>Lippincott-Raven Publishers</pub><pmid>6184558</pmid><doi>10.1097/00005344-198200433-00009</doi><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0160-2446 |
| ispartof | Journal of cardiovascular pharmacology, 1982, Vol.4 Suppl 3 (Supplement 3), p.S306-S306 |
| issn | 0160-2446 1533-4023 |
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| source | MEDLINE; Journals@Ovid LWW Legacy Archive; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Journals@Ovid Ovid Autoload |
| subjects | Adult Aged Blood Pressure - drug effects Calcium - metabolism Calcium Channel Blockers - pharmacology Creatinine - blood Erythrocytes - metabolism Female Humans Hypertension - metabolism Hypertension - physiopathology Intracellular Fluid - metabolism Male Middle Aged Nifedipine - pharmacology Pyridines - pharmacology |
| title | Effect of Nifedipine on Blood Pressure and on Intracellular Calcium in Arterial Hypertension |
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