Isotachophoresis of cerebrospinal fluid
Unconcentrated cerebrospinal fluid (CSF) was mixed in a constant ratio with carrier ampholytes and spacer amino acids and analysed by isotachophoresis. Examination of the cerebrospinal fluids from 113 patients showed characteristic patterns for normal, acute viral and acute bacterial meningitis. CSF...
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| Veröffentlicht in: | Journal of the neurological sciences 1982-11, Vol.56 (2), p.283-292 |
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| container_end_page | 292 |
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| container_issue | 2 |
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| container_title | Journal of the neurological sciences |
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| creator | Smuts, Heidi E.M. Russell, B.W. Moodie, J.W. |
| description | Unconcentrated cerebrospinal fluid (CSF) was mixed in a constant ratio with carrier ampholytes and spacer amino acids and analysed by isotachophoresis. Examination of the cerebrospinal fluids from 113 patients showed characteristic patterns for normal, acute viral and acute bacterial meningitis. CSF from cases of subacute sclerosing panencephalitis (SSPE) and multiple sclerosis (MS) differed from these and from each other in the gamma-globulin region. This technique provides useful information on the integrity of the blood-brain barrier and is able to determine whether immunoglobulins present arise within the central nervous system or enter through a damaged barrier. |
| doi_str_mv | 10.1016/0022-510X(82)90149-6 |
| format | Article |
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Examination of the cerebrospinal fluids from 113 patients showed characteristic patterns for normal, acute viral and acute bacterial meningitis. CSF from cases of subacute sclerosing panencephalitis (SSPE) and multiple sclerosis (MS) differed from these and from each other in the gamma-globulin region. 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Examination of the cerebrospinal fluids from 113 patients showed characteristic patterns for normal, acute viral and acute bacterial meningitis. CSF from cases of subacute sclerosing panencephalitis (SSPE) and multiple sclerosis (MS) differed from these and from each other in the gamma-globulin region. This technique provides useful information on the integrity of the blood-brain barrier and is able to determine whether immunoglobulins present arise within the central nervous system or enter through a damaged barrier.</description><subject>Blood-Brain Barrier</subject><subject>Central Nervous System Diseases - cerebrospinal fluid</subject><subject>Cryptococcosis - cerebrospinal fluid</subject><subject>Humans</subject><subject>Immunoglobulins - cerebrospinal fluid</subject><subject>Meningitis - cerebrospinal fluid</subject><subject>Meningitis, Viral - cerebrospinal fluid</subject><subject>Meningoencephalitis - cerebrospinal fluid</subject><subject>Multiple Sclerosis - cerebrospinal fluid</subject><subject>Subacute Sclerosing Panencephalitis - cerebrospinal fluid</subject><subject>Subarachnoid Hemorrhage - cerebrospinal fluid</subject><issn>0022-510X</issn><issn>1878-5883</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1982</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UMtKAzEUDaLUWv0Dha58LEaTzOS1EaT4KBTcKLgLmeQOjUybMZkR_HtTW7p0dS-cx73nIHRO8C3BhN9hTGnBCP64lvRGYVKpgh-gMZFCFkzK8hCN95RjdJLSJ8aYS6lGaCSIYIzRMbqap9AbuwzdMkRIPk1DM7UQoY4hdX5t2mnTDt6doqPGtAnOdnOC3p8e32YvxeL1eT57WBS2ZKIveC0qa2QlGPCGlqYyjhMHlitgFVCqXF6ckk5Qw5VUDNeC1VAbkZXKqnKCLre-XQxfA6Rer3yy0LZmDWFIWuZEjGGaidWWaPOjKUKju-hXJv5ogvWmH70JrzfhtaT6rx_Ns-xi5z_UK3B70a6QjN9vccghvz1EnayHtQXnI9heu-D_P_AL-4B0Fw</recordid><startdate>198211</startdate><enddate>198211</enddate><creator>Smuts, Heidi E.M.</creator><creator>Russell, B.W.</creator><creator>Moodie, J.W.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198211</creationdate><title>Isotachophoresis of cerebrospinal fluid</title><author>Smuts, Heidi E.M. ; Russell, B.W. ; Moodie, J.W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-6b74ca8475e6f23a4ad61dec69e54e229d9e5d98d72a698950b75beba76b79c93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1982</creationdate><topic>Blood-Brain Barrier</topic><topic>Central Nervous System Diseases - cerebrospinal fluid</topic><topic>Cryptococcosis - cerebrospinal fluid</topic><topic>Humans</topic><topic>Immunoglobulins - cerebrospinal fluid</topic><topic>Meningitis - cerebrospinal fluid</topic><topic>Meningitis, Viral - cerebrospinal fluid</topic><topic>Meningoencephalitis - cerebrospinal fluid</topic><topic>Multiple Sclerosis - cerebrospinal fluid</topic><topic>Subacute Sclerosing Panencephalitis - cerebrospinal fluid</topic><topic>Subarachnoid Hemorrhage - cerebrospinal fluid</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Smuts, Heidi E.M.</creatorcontrib><creatorcontrib>Russell, B.W.</creatorcontrib><creatorcontrib>Moodie, J.W.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the neurological sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Smuts, Heidi E.M.</au><au>Russell, B.W.</au><au>Moodie, J.W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Isotachophoresis of cerebrospinal fluid</atitle><jtitle>Journal of the neurological sciences</jtitle><addtitle>J Neurol Sci</addtitle><date>1982-11</date><risdate>1982</risdate><volume>56</volume><issue>2</issue><spage>283</spage><epage>292</epage><pages>283-292</pages><issn>0022-510X</issn><eissn>1878-5883</eissn><abstract>Unconcentrated cerebrospinal fluid (CSF) was mixed in a constant ratio with carrier ampholytes and spacer amino acids and analysed by isotachophoresis. 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| fulltext | fulltext |
| identifier | ISSN: 0022-510X |
| ispartof | Journal of the neurological sciences, 1982-11, Vol.56 (2), p.283-292 |
| issn | 0022-510X 1878-5883 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_80225502 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Blood-Brain Barrier Central Nervous System Diseases - cerebrospinal fluid Cryptococcosis - cerebrospinal fluid Humans Immunoglobulins - cerebrospinal fluid Meningitis - cerebrospinal fluid Meningitis, Viral - cerebrospinal fluid Meningoencephalitis - cerebrospinal fluid Multiple Sclerosis - cerebrospinal fluid Subacute Sclerosing Panencephalitis - cerebrospinal fluid Subarachnoid Hemorrhage - cerebrospinal fluid |
| title | Isotachophoresis of cerebrospinal fluid |
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