Esters of Nipecotic and Isonipecotic Acids as Potential Anticonvulsants

A variety of esters of nipecotic and isonipecotic acids were synthesized and evaluated for anticonvulsant activity. The ester group was varied in terms of lipophilicity and reactivity toward hydrolysis. The esters were screened against seizures induced by electroshock, pentylenetetrazol, and the put...

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Veröffentlicht in:	Journal of pharmaceutical sciences 1982-11, Vol.71 (11), p.1214-1219
Hauptverfasser:	Michael Crider, A., Tita, Terence T., Wood, J.D., Hinko, Christine N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anticonvulsants - chemical synthesis Anticonvulsants-potential Anticonvulsants—potential, esters of nipecotic and isonipecotic acids, mice Bicuculline - antagonists & inhibitors Chemical Phenomena Chemistry Chemistry, Physical esters of nipecotic and isonipecotic acids isonipecotic acid Isonipecotic acid-esters Isonipecotic Acids - chemical synthesis Isonipecotic Acids - pharmacology Isonipecotic acid—esters, nipecotic acid, potential anticonvulsants, mice Keyphrases Mice nipecotic acid Nipecotic acid-esters Nipecotic Acids - chemical synthesis Nipecotic Acids - pharmacology Nipecotic acid—esters, isonipecotic acid, potential anticonvulsants, mice Pentylenetetrazole - antagonists & inhibitors potential anticonvulsants
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