Rearrangement, Amplification and Overexpression of c-Ha Ras Gene in Premalignant Lesion of Turcot's Syndrome
Ras gene family (c-Ha, Ki, N ras) and c-myc proto-oncogenes were analyzed in seven colonic and three gastric adenomatous polyps obtained from a patient with Turcot's syndrome. The rearrangement and amplification as well as overexpression of c-Ha ras gene in one colonic adenomatous polyp were de...
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| Veröffentlicht in: | Japanese Journal of Medicine 1990, Vol.29(4), pp.391-396 |
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| container_end_page | 396 |
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| container_start_page | 391 |
| container_title | Japanese Journal of Medicine |
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| creator | MINAMI, Takeshi HIMENO, Seiichi SHINOMURA, Yasuhisa KARIYA, Yoshinori TARUI, Seiichiro SAKURAI, Masami |
| description | Ras gene family (c-Ha, Ki, N ras) and c-myc proto-oncogenes were analyzed in seven colonic and three gastric adenomatous polyps obtained from a patient with Turcot's syndrome. The rearrangement and amplification as well as overexpression of c-Ha ras gene in one colonic adenomatous polyp were determined. The amplified c-Ha ras gene in this polyp revealed larger fragments of BamHI, PstI and Sad than those in the normal colonic mucosa from the same patient. But, such abnormalities were not observed in other polyps. No abnormalities of c-Ki ras, c-N ras or c-myc gene were observed in any polyps. These results suggest that the alternations of c-Ha ras gene in this patient may not be responsible for the adenomatous change, but may be related to the transition from adenoma to carcinoma of the colon. |
| doi_str_mv | 10.2169/internalmedicine1962.29.391 |
| format | Article |
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The rearrangement and amplification as well as overexpression of c-Ha ras gene in one colonic adenomatous polyp were determined. The amplified c-Ha ras gene in this polyp revealed larger fragments of BamHI, PstI and Sad than those in the normal colonic mucosa from the same patient. But, such abnormalities were not observed in other polyps. No abnormalities of c-Ki ras, c-N ras or c-myc gene were observed in any polyps. These results suggest that the alternations of c-Ha ras gene in this patient may not be responsible for the adenomatous change, but may be related to the transition from adenoma to carcinoma of the colon.</description><identifier>ISSN: 0021-5120</identifier><identifier>EISSN: 1881-123X</identifier><identifier>DOI: 10.2169/internalmedicine1962.29.391</identifier><identifier>PMID: 1703248</identifier><language>eng</language><publisher>Japan: The Japanese Society of Internal Medicine</publisher><subject>Adenoma - genetics ; Adenoma - pathology ; Adult ; Blotting, Northern ; Blotting, Southern ; Brain Neoplasms - genetics ; c-Ha ras proto-oncogene ; Colonic polyp ; Colonic Polyps - genetics ; DNA - analysis ; Gene Rearrangement ; Genes, ras - genetics ; Glioma - genetics ; Humans ; Male ; Malignant potential ; Multigene Family ; Polyps - genetics ; Polyps - pathology ; RNA - analysis ; Stomach Neoplasms - genetics ; Syndrome</subject><ispartof>Japanese Journal of Medicine, 1990, Vol.29(4), pp.391-396</ispartof><rights>The Japanese Society of Internal Medicine</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c444t-f01f302783ca4b1d8c3a12d11a4462c79350a834278ca98833b5df2c9ecff193</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1876,4009,27902,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1703248$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MINAMI, Takeshi</creatorcontrib><creatorcontrib>HIMENO, Seiichi</creatorcontrib><creatorcontrib>SHINOMURA, Yasuhisa</creatorcontrib><creatorcontrib>KARIYA, Yoshinori</creatorcontrib><creatorcontrib>TARUI, Seiichiro</creatorcontrib><creatorcontrib>SAKURAI, Masami</creatorcontrib><title>Rearrangement, Amplification and Overexpression of c-Ha Ras Gene in Premalignant Lesion of Turcot's Syndrome</title><title>Japanese Journal of Medicine</title><addtitle>Japanese Journal of Medicine</addtitle><description>Ras gene family (c-Ha, Ki, N ras) and c-myc proto-oncogenes were analyzed in seven colonic and three gastric adenomatous polyps obtained from a patient with Turcot's syndrome. The rearrangement and amplification as well as overexpression of c-Ha ras gene in one colonic adenomatous polyp were determined. The amplified c-Ha ras gene in this polyp revealed larger fragments of BamHI, PstI and Sad than those in the normal colonic mucosa from the same patient. But, such abnormalities were not observed in other polyps. No abnormalities of c-Ki ras, c-N ras or c-myc gene were observed in any polyps. These results suggest that the alternations of c-Ha ras gene in this patient may not be responsible for the adenomatous change, but may be related to the transition from adenoma to carcinoma of the colon.</description><subject>Adenoma - genetics</subject><subject>Adenoma - pathology</subject><subject>Adult</subject><subject>Blotting, Northern</subject><subject>Blotting, Southern</subject><subject>Brain Neoplasms - genetics</subject><subject>c-Ha ras proto-oncogene</subject><subject>Colonic polyp</subject><subject>Colonic Polyps - genetics</subject><subject>DNA - analysis</subject><subject>Gene Rearrangement</subject><subject>Genes, ras - genetics</subject><subject>Glioma - genetics</subject><subject>Humans</subject><subject>Male</subject><subject>Malignant potential</subject><subject>Multigene Family</subject><subject>Polyps - genetics</subject><subject>Polyps - pathology</subject><subject>RNA - analysis</subject><subject>Stomach Neoplasms - genetics</subject><subject>Syndrome</subject><issn>0021-5120</issn><issn>1881-123X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kNFrFDEQxoNY6tn6JwgBQV_caybJ3SX4VIq2wkFLew--hbns5EzZzZ5JTux_75at9UVfZmC-38w3fIy9AzGXsLRnMVXKCbue2uhjIrBLOZd2riy8YDMwBhqQ6ttLNhNCQrMAKV6x16XcC6GX0shjdgwroaQ2M9bdEuaMaUc9pfqRn_f7LoboscYhcUwtv_5JmX7tM5XyOBoC980V8lss_JIS8Zj4TaYeu7hLmCpf0x9uc8h-qB8Kv3tIbR56OmVHAbtCb576Cdt8-by5uGrW15dfL87Xjdda1yYICErIlVEe9RZa4xWCbAFQj__7lVULgUbpkfBojVFqu2iD9JZ8CGDVCXs_nd3n4ceBSnV9LJ66DhMNh-KMkFIppUfw0wT6PJSSKbh9jj3mBwfCPUbt_hW1k9aNUY_bb59sDttR_7s7ZTvqN5N-Xyru6FnHXKPv6L-39VRGi2fUf8fsKKnfWkeeEg</recordid><startdate>1990</startdate><enddate>1990</enddate><creator>MINAMI, Takeshi</creator><creator>HIMENO, Seiichi</creator><creator>SHINOMURA, Yasuhisa</creator><creator>KARIYA, Yoshinori</creator><creator>TARUI, Seiichiro</creator><creator>SAKURAI, Masami</creator><general>The Japanese Society of Internal Medicine</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1990</creationdate><title>Rearrangement, Amplification and Overexpression of c-Ha Ras Gene in Premalignant Lesion of Turcot's Syndrome</title><author>MINAMI, Takeshi ; HIMENO, Seiichi ; SHINOMURA, Yasuhisa ; KARIYA, Yoshinori ; TARUI, Seiichiro ; SAKURAI, Masami</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c444t-f01f302783ca4b1d8c3a12d11a4462c79350a834278ca98833b5df2c9ecff193</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Adenoma - genetics</topic><topic>Adenoma - pathology</topic><topic>Adult</topic><topic>Blotting, Northern</topic><topic>Blotting, Southern</topic><topic>Brain Neoplasms - genetics</topic><topic>c-Ha ras proto-oncogene</topic><topic>Colonic polyp</topic><topic>Colonic Polyps - genetics</topic><topic>DNA - analysis</topic><topic>Gene Rearrangement</topic><topic>Genes, ras - genetics</topic><topic>Glioma - genetics</topic><topic>Humans</topic><topic>Male</topic><topic>Malignant potential</topic><topic>Multigene Family</topic><topic>Polyps - genetics</topic><topic>Polyps - pathology</topic><topic>RNA - analysis</topic><topic>Stomach Neoplasms - genetics</topic><topic>Syndrome</topic><toplevel>online_resources</toplevel><creatorcontrib>MINAMI, Takeshi</creatorcontrib><creatorcontrib>HIMENO, Seiichi</creatorcontrib><creatorcontrib>SHINOMURA, Yasuhisa</creatorcontrib><creatorcontrib>KARIYA, Yoshinori</creatorcontrib><creatorcontrib>TARUI, Seiichiro</creatorcontrib><creatorcontrib>SAKURAI, Masami</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Japanese Journal of Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MINAMI, Takeshi</au><au>HIMENO, Seiichi</au><au>SHINOMURA, Yasuhisa</au><au>KARIYA, Yoshinori</au><au>TARUI, Seiichiro</au><au>SAKURAI, Masami</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Rearrangement, Amplification and Overexpression of c-Ha Ras Gene in Premalignant Lesion of Turcot's Syndrome</atitle><jtitle>Japanese Journal of Medicine</jtitle><addtitle>Japanese Journal of Medicine</addtitle><date>1990</date><risdate>1990</risdate><volume>29</volume><issue>4</issue><spage>391</spage><epage>396</epage><pages>391-396</pages><issn>0021-5120</issn><eissn>1881-123X</eissn><abstract>Ras gene family (c-Ha, Ki, N ras) and c-myc proto-oncogenes were analyzed in seven colonic and three gastric adenomatous polyps obtained from a patient with Turcot's syndrome. The rearrangement and amplification as well as overexpression of c-Ha ras gene in one colonic adenomatous polyp were determined. The amplified c-Ha ras gene in this polyp revealed larger fragments of BamHI, PstI and Sad than those in the normal colonic mucosa from the same patient. But, such abnormalities were not observed in other polyps. No abnormalities of c-Ki ras, c-N ras or c-myc gene were observed in any polyps. These results suggest that the alternations of c-Ha ras gene in this patient may not be responsible for the adenomatous change, but may be related to the transition from adenoma to carcinoma of the colon.</abstract><cop>Japan</cop><pub>The Japanese Society of Internal Medicine</pub><pmid>1703248</pmid><doi>10.2169/internalmedicine1962.29.391</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Japanese Journal of Medicine, 1990, Vol.29(4), pp.391-396 |
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| language | eng |
| recordid | cdi_proquest_miscellaneous_80223334 |
| source | J-STAGE Free; MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Adenoma - genetics Adenoma - pathology Adult Blotting, Northern Blotting, Southern Brain Neoplasms - genetics c-Ha ras proto-oncogene Colonic polyp Colonic Polyps - genetics DNA - analysis Gene Rearrangement Genes, ras - genetics Glioma - genetics Humans Male Malignant potential Multigene Family Polyps - genetics Polyps - pathology RNA - analysis Stomach Neoplasms - genetics Syndrome |
| title | Rearrangement, Amplification and Overexpression of c-Ha Ras Gene in Premalignant Lesion of Turcot's Syndrome |
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