Isolation, Identification, and Synthesis of the Major Sulpiride Metabolite in Primates

The major metabolite of sulpiride, iV-[(l-ethyl-2-pyrroli-diny])methyl]-5-sulfamoyl-2-anisamide (I), in the monkey is JV-[(1-ethy]-5-oxo-2-pyrrolidinyl)methyl]-5-sulfamoyl-2-anisamide (II). It is also a metabolite in other laboratory animal species and possibly at very low levels in humans. Treatmen...

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Veröffentlicht in:	Journal of pharmaceutical sciences 1982-11, Vol.71 (11), p.1199-1203
Hauptverfasser:	Brennan, J.J., Imondi, A.R., Westmoreland, D.G., Williamson, M.J.
Format:	Artikel
Sprache:	eng
Schlagworte:	and synthesis and synthesis of major metabolites Animals Biotransformation Chromatography, High Pressure Liquid High-pressure liquid chromatography-analysis High-pressure liquid chromatography—analysis, major sulpiride metabolites, monkeys identification isolation Keyphrases Macaca mulatta Magnetic Resonance Spectroscopy major sulpiride metabolites Male Metabolites-sulpiride Metabolites— sulpiride, isolation, identification, and synthesis, monkeys monkeys Sulpiride - analogs & derivatives Sulpiride - chemical synthesis Sulpiride - isolation & purification Sulpiride - metabolism Sulpiride-isolation Sulpiride—isolation, identification, and synthesis of major metabolites, monkeys
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