Exogenous Somatostatin Raises Plasma Insulin Levels in Patients with Insulin-Dependent Diabetes Mellitus
Summary The effect of cyclic somatostatin on circulating insulin levels was studied in eight patients with insulin-dependent diabetes mellitus (IDDM). The study was performed after an overnight fast when their subcutaneous depots of insulin had been depleted during i. v. insulin substitution for 18...
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| Veröffentlicht in: | Hormone and metabolic research 1990-11, Vol.22 (11), p.581-583 |
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| container_issue | 11 |
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| container_title | Hormone and metabolic research |
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| creator | Kollind, M. Moberg, E. Lins, P.-E. Adamson, U. |
| description | Summary
The effect of cyclic somatostatin on circulating insulin levels was studied in eight patients with insulin-dependent diabetes mellitus (IDDM). The study was performed after an overnight fast when their subcutaneous depots of insulin had been depleted during i. v. insulin substitution for 18 hours. A constant rate i. v. insulin infusion (0.4 mU/kg/min) was given for 240 min and somatostatin was co-infused between 60-120 min (100 μg/h) and 180-240 min (250 μg/h) respectively. Plasma insulin, blood glucose and hematocrit were measured at 15 min intervals. Hematocrit fell from 41.7 to 38.3% during the study period. Somatostatin increased the plasma insulin levels, corrected for the changes of hematocrit, by approximately 8% in the low dose (P < 0.05) as well as in the high dose (P < 0.05) period. It is concluded that somatostatin interferes with the clearance of insulin thereby increasing the circulating plasma insulin levels in IDDM patients without residual insulin secretion. |
| doi_str_mv | 10.1055/s-2007-1004978 |
| format | Article |
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The effect of cyclic somatostatin on circulating insulin levels was studied in eight patients with insulin-dependent diabetes mellitus (IDDM). The study was performed after an overnight fast when their subcutaneous depots of insulin had been depleted during i. v. insulin substitution for 18 hours. A constant rate i. v. insulin infusion (0.4 mU/kg/min) was given for 240 min and somatostatin was co-infused between 60-120 min (100 μg/h) and 180-240 min (250 μg/h) respectively. Plasma insulin, blood glucose and hematocrit were measured at 15 min intervals. Hematocrit fell from 41.7 to 38.3% during the study period. Somatostatin increased the plasma insulin levels, corrected for the changes of hematocrit, by approximately 8% in the low dose (P < 0.05) as well as in the high dose (P < 0.05) period. It is concluded that somatostatin interferes with the clearance of insulin thereby increasing the circulating plasma insulin levels in IDDM patients without residual insulin secretion.</description><identifier>ISSN: 0018-5043</identifier><identifier>EISSN: 1439-4286</identifier><identifier>DOI: 10.1055/s-2007-1004978</identifier><identifier>PMID: 1980258</identifier><identifier>CODEN: HMMRA2</identifier><language>eng</language><publisher>Stuttgart: Thieme</publisher><subject>Adult ; Biological and medical sciences ; Blood Glucose - metabolism ; Clinical ; Diabetes Mellitus, Type 1 - blood ; Diabetes. Impaired glucose tolerance ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Female ; Hematocrit ; Humans ; Insulin - blood ; Kinetics ; Male ; Medical sciences ; Somatostatin - administration & dosage ; Somatostatin - pharmacology</subject><ispartof>Hormone and metabolic research, 1990-11, Vol.22 (11), p.581-583</ispartof><rights>Georg Thieme Verlag, Stuttgart · New York</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c388t-efcfc47ad71530db308d302bba1c380a98828ea1470f002dc332d66402dd38473</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-2007-1004978.pdf$$EPDF$$P50$$Gthieme$$H</linktopdf><link.rule.ids>314,780,784,3017,3018,27924,27925,54559</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5069757$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1980258$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kollind, M.</creatorcontrib><creatorcontrib>Moberg, E.</creatorcontrib><creatorcontrib>Lins, P.-E.</creatorcontrib><creatorcontrib>Adamson, U.</creatorcontrib><title>Exogenous Somatostatin Raises Plasma Insulin Levels in Patients with Insulin-Dependent Diabetes Mellitus</title><title>Hormone and metabolic research</title><addtitle>Horm Metab Res</addtitle><description>Summary
The effect of cyclic somatostatin on circulating insulin levels was studied in eight patients with insulin-dependent diabetes mellitus (IDDM). The study was performed after an overnight fast when their subcutaneous depots of insulin had been depleted during i. v. insulin substitution for 18 hours. A constant rate i. v. insulin infusion (0.4 mU/kg/min) was given for 240 min and somatostatin was co-infused between 60-120 min (100 μg/h) and 180-240 min (250 μg/h) respectively. Plasma insulin, blood glucose and hematocrit were measured at 15 min intervals. Hematocrit fell from 41.7 to 38.3% during the study period. Somatostatin increased the plasma insulin levels, corrected for the changes of hematocrit, by approximately 8% in the low dose (P < 0.05) as well as in the high dose (P < 0.05) period. It is concluded that somatostatin interferes with the clearance of insulin thereby increasing the circulating plasma insulin levels in IDDM patients without residual insulin secretion.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Blood Glucose - metabolism</subject><subject>Clinical</subject><subject>Diabetes Mellitus, Type 1 - blood</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Etiopathogenesis. Screening. Investigations. Target tissue resistance</subject><subject>Female</subject><subject>Hematocrit</subject><subject>Humans</subject><subject>Insulin - blood</subject><subject>Kinetics</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Somatostatin - administration & dosage</subject><subject>Somatostatin - pharmacology</subject><issn>0018-5043</issn><issn>1439-4286</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1P3DAQhq2Kii7Qa29IOSBuhnFsJ86xYvlYaauuCpwtJ5mwRvnYZhxa_j1e7Zaeqp48nnk843dexr4IuBCg9SXxFCDnAkAVufnAZkLJgqvUZAdsBiAM16DkJ3ZE9ByvqhDqkB2KwkCqzYytr38PT9gPEyX3Q-fCQMEF3yc_nCekZNU66lyy6GlqY3aJL9hSEqNVpLAPlPzyYf2nzue4wb6O-WTuXYkhdviGbevDRCfsY-Naws_785g93lw_XN3x5ffbxdXXJa-kMYFjUzWVyl2dCy2hLiWYWkJalk5EAFxhTGrQCZVDA5DWlZRpnWUqhrU0KpfH7HzXdzMOPyekYDtPVfyE6zGqtFG3yGUm_wsKXaSZNkUEL3ZgNQ5EIzZ2M_rOja9WgN16YMluPbB7D-KD033nqeyw_ovvlh7rZ_u6o8q1zej6ytM7piErcr1VwndYWHvs0D4P09jH1f1r7BtqdZzj</recordid><startdate>19901101</startdate><enddate>19901101</enddate><creator>Kollind, M.</creator><creator>Moberg, E.</creator><creator>Lins, P.-E.</creator><creator>Adamson, U.</creator><general>Thieme</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19901101</creationdate><title>Exogenous Somatostatin Raises Plasma Insulin Levels in Patients with Insulin-Dependent Diabetes Mellitus</title><author>Kollind, M. ; Moberg, E. ; Lins, P.-E. ; Adamson, U.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c388t-efcfc47ad71530db308d302bba1c380a98828ea1470f002dc332d66402dd38473</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Blood Glucose - metabolism</topic><topic>Clinical</topic><topic>Diabetes Mellitus, Type 1 - blood</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Etiopathogenesis. Screening. Investigations. Target tissue resistance</topic><topic>Female</topic><topic>Hematocrit</topic><topic>Humans</topic><topic>Insulin - blood</topic><topic>Kinetics</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Somatostatin - administration & dosage</topic><topic>Somatostatin - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kollind, M.</creatorcontrib><creatorcontrib>Moberg, E.</creatorcontrib><creatorcontrib>Lins, P.-E.</creatorcontrib><creatorcontrib>Adamson, U.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Hormone and metabolic research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kollind, M.</au><au>Moberg, E.</au><au>Lins, P.-E.</au><au>Adamson, U.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Exogenous Somatostatin Raises Plasma Insulin Levels in Patients with Insulin-Dependent Diabetes Mellitus</atitle><jtitle>Hormone and metabolic research</jtitle><addtitle>Horm Metab Res</addtitle><date>1990-11-01</date><risdate>1990</risdate><volume>22</volume><issue>11</issue><spage>581</spage><epage>583</epage><pages>581-583</pages><issn>0018-5043</issn><eissn>1439-4286</eissn><coden>HMMRA2</coden><abstract>Summary
The effect of cyclic somatostatin on circulating insulin levels was studied in eight patients with insulin-dependent diabetes mellitus (IDDM). The study was performed after an overnight fast when their subcutaneous depots of insulin had been depleted during i. v. insulin substitution for 18 hours. A constant rate i. v. insulin infusion (0.4 mU/kg/min) was given for 240 min and somatostatin was co-infused between 60-120 min (100 μg/h) and 180-240 min (250 μg/h) respectively. Plasma insulin, blood glucose and hematocrit were measured at 15 min intervals. Hematocrit fell from 41.7 to 38.3% during the study period. Somatostatin increased the plasma insulin levels, corrected for the changes of hematocrit, by approximately 8% in the low dose (P < 0.05) as well as in the high dose (P < 0.05) period. It is concluded that somatostatin interferes with the clearance of insulin thereby increasing the circulating plasma insulin levels in IDDM patients without residual insulin secretion.</abstract><cop>Stuttgart</cop><cop>New York, NY</cop><pub>Thieme</pub><pmid>1980258</pmid><doi>10.1055/s-2007-1004978</doi><tpages>3</tpages></addata></record> |
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| language | eng |
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| source | MEDLINE; Thieme Connect Journals |
| subjects | Adult Biological and medical sciences Blood Glucose - metabolism Clinical Diabetes Mellitus, Type 1 - blood Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Female Hematocrit Humans Insulin - blood Kinetics Male Medical sciences Somatostatin - administration & dosage Somatostatin - pharmacology |
| title | Exogenous Somatostatin Raises Plasma Insulin Levels in Patients with Insulin-Dependent Diabetes Mellitus |
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