Control of Fetal Membrane Prostaglandin E2 Production by Bacteria
The effect of bacteria on the production of prostaglandin E2 (PGE2) and PGE2 metabolites by fetal membranes has been investigated. Live bacteria stimulated a large increase in the levels of PGE2 metabolites, but only a small increase in the levels of PGE2 on the fetal side of the membranes. No signi...
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| Veröffentlicht in: | Acta obstetricia et gynecologica Scandinavica 1990, Vol.69 (5), p.405-408 |
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| container_issue | 5 |
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| container_title | Acta obstetricia et gynecologica Scandinavica |
| container_volume | 69 |
| creator | Helmig, Rikke Roseblade, Christopher K. Uldbjerg, Niels Elder, Murdoch G. Sullivan, Mark H. F. |
| description | The effect of bacteria on the production of prostaglandin E2 (PGE2) and PGE2 metabolites by fetal membranes has been investigated. Live bacteria stimulated a large increase in the levels of PGE2 metabolites, but only a small increase in the levels of PGE2 on the fetal side of the membranes. No significant changes in the levels of PGE2 or its metabolites were found on the maternal side. Bacteria may therefore stimulate PGE2 production by fetal membranes during short-term incubations, but it seems that the metabolic capacity of the chorion was so high that no change in PGE2 levels was detectable on the maternal side of the fetal membranes. This was confirmed by the finding that < 1 % of 3H-PGE2 added to the fetal side of the membrane reached the maternal side without being metabolized. |
| doi_str_mv | 10.3109/00016349009013302 |
| format | Article |
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This was confirmed by the finding that < 1 % of 3H-PGE2 added to the fetal side of the membrane reached the maternal side without being metabolized.</description><identifier>ISSN: 0001-6349</identifier><identifier>EISSN: 1600-0412</identifier><identifier>DOI: 10.3109/00016349009013302</identifier><identifier>PMID: 2270765</identifier><identifier>CODEN: AOGSAE</identifier><language>eng</language><publisher>Oxford, UK: Informa UK Ltd</publisher><subject>Biological and medical sciences ; Culture Techniques ; Dinoprostone - metabolism ; Escherichia coli ; Extraembryonic Membranes - metabolism ; Extraembryonic Membranes - microbiology ; Female ; Gynecology. Andrology. Obstetrics ; Humans ; Lactobacillus ; Management. Prenatal diagnosis ; Medical sciences ; Pregnancy ; Pregnancy. Fetus. Placenta ; Streptococcus agalactiae</subject><ispartof>Acta obstetricia et gynecologica Scandinavica, 1990, Vol.69 (5), p.405-408</ispartof><rights>1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1990</rights><rights>1990 Acta Obstet Gynecol Scand</rights><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5063-8c6fbfa5378fe8ac3eb9e95ae625cfa3b114f47af9d0f91d9546b25fa85564f03</citedby><cites>FETCH-LOGICAL-c5063-8c6fbfa5378fe8ac3eb9e95ae625cfa3b114f47af9d0f91d9546b25fa85564f03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.3109%2F00016349009013302$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.3109%2F00016349009013302$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,4024,27923,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19611530$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2270765$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Helmig, Rikke</creatorcontrib><creatorcontrib>Roseblade, Christopher K.</creatorcontrib><creatorcontrib>Uldbjerg, Niels</creatorcontrib><creatorcontrib>Elder, Murdoch G.</creatorcontrib><creatorcontrib>Sullivan, Mark H. F.</creatorcontrib><title>Control of Fetal Membrane Prostaglandin E2 Production by Bacteria</title><title>Acta obstetricia et gynecologica Scandinavica</title><addtitle>Acta Obstet Gynecol Scand</addtitle><description>The effect of bacteria on the production of prostaglandin E2 (PGE2) and PGE2 metabolites by fetal membranes has been investigated. Live bacteria stimulated a large increase in the levels of PGE2 metabolites, but only a small increase in the levels of PGE2 on the fetal side of the membranes. No significant changes in the levels of PGE2 or its metabolites were found on the maternal side. Bacteria may therefore stimulate PGE2 production by fetal membranes during short-term incubations, but it seems that the metabolic capacity of the chorion was so high that no change in PGE2 levels was detectable on the maternal side of the fetal membranes. This was confirmed by the finding that < 1 % of 3H-PGE2 added to the fetal side of the membrane reached the maternal side without being metabolized.</description><subject>Biological and medical sciences</subject><subject>Culture Techniques</subject><subject>Dinoprostone - metabolism</subject><subject>Escherichia coli</subject><subject>Extraembryonic Membranes - metabolism</subject><subject>Extraembryonic Membranes - microbiology</subject><subject>Female</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Lactobacillus</subject><subject>Management. Prenatal diagnosis</subject><subject>Medical sciences</subject><subject>Pregnancy</subject><subject>Pregnancy. Fetus. Placenta</subject><subject>Streptococcus agalactiae</subject><issn>0001-6349</issn><issn>1600-0412</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1u1DAUhS0EKkPhAVggZQO7wLUdO7FYTYd2oLS0CxCIjXXj2DQliYudqMzb19FEZYEEK8s-37k_x4Q8p_CaU1BvAIBKXigABZRzYA_IikqAHArKHpLVrOcz8Jg8ifE63VhZVAfkgLESSilWZL3xwxh8l3mXndgRu-zc9nXAwWaXwccRf3Q4NO2QHbP5oZnM2Pohq3fZEZrRhhafkkcOu2ifLech-XJy_HnzPj-72H7YrM9yI0DyvDLS1Q4FLytnKzTc1soqgVYyYRzymtLCFSU61YBTtFGikDUTDishZOGAH5JX-7o3wf-abBx130ZjuzSf9VPUFTDKZDWDdA-atEAM1umb0PYYdpqCnmPTf8WWPC-W4lPd2-beseSU9JeLjtFg51JApo1_CitJqeBzb7nnbtvO7v7fWK8vtiUInoz53tjG0f6-N2L4qWXJS6G_ftpqcfr92-U7JvTHxL9d-MH50OOVxW68MhisvvZTGNJP_GPdO3o2pAM</recordid><startdate>1990</startdate><enddate>1990</enddate><creator>Helmig, Rikke</creator><creator>Roseblade, Christopher K.</creator><creator>Uldbjerg, Niels</creator><creator>Elder, Murdoch G.</creator><creator>Sullivan, Mark H. 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Placenta</topic><topic>Streptococcus agalactiae</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Helmig, Rikke</creatorcontrib><creatorcontrib>Roseblade, Christopher K.</creatorcontrib><creatorcontrib>Uldbjerg, Niels</creatorcontrib><creatorcontrib>Elder, Murdoch G.</creatorcontrib><creatorcontrib>Sullivan, Mark H. 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F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Control of Fetal Membrane Prostaglandin E2 Production by Bacteria</atitle><jtitle>Acta obstetricia et gynecologica Scandinavica</jtitle><addtitle>Acta Obstet Gynecol Scand</addtitle><date>1990</date><risdate>1990</risdate><volume>69</volume><issue>5</issue><spage>405</spage><epage>408</epage><pages>405-408</pages><issn>0001-6349</issn><eissn>1600-0412</eissn><coden>AOGSAE</coden><abstract>The effect of bacteria on the production of prostaglandin E2 (PGE2) and PGE2 metabolites by fetal membranes has been investigated. Live bacteria stimulated a large increase in the levels of PGE2 metabolites, but only a small increase in the levels of PGE2 on the fetal side of the membranes. No significant changes in the levels of PGE2 or its metabolites were found on the maternal side. Bacteria may therefore stimulate PGE2 production by fetal membranes during short-term incubations, but it seems that the metabolic capacity of the chorion was so high that no change in PGE2 levels was detectable on the maternal side of the fetal membranes. This was confirmed by the finding that < 1 % of 3H-PGE2 added to the fetal side of the membrane reached the maternal side without being metabolized.</abstract><cop>Oxford, UK</cop><pub>Informa UK Ltd</pub><pmid>2270765</pmid><doi>10.3109/00016349009013302</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Acta obstetricia et gynecologica Scandinavica, 1990, Vol.69 (5), p.405-408 |
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| language | eng |
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| source | MEDLINE; Access via Wiley Online Library |
| subjects | Biological and medical sciences Culture Techniques Dinoprostone - metabolism Escherichia coli Extraembryonic Membranes - metabolism Extraembryonic Membranes - microbiology Female Gynecology. Andrology. Obstetrics Humans Lactobacillus Management. Prenatal diagnosis Medical sciences Pregnancy Pregnancy. Fetus. Placenta Streptococcus agalactiae |
| title | Control of Fetal Membrane Prostaglandin E2 Production by Bacteria |
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