Flumethason-induced calving is preceded by a period of myometrial inhibition during luteolysis
The temporal relationship among changes of the concentrations of the 13,14-dihydro-15-keto metabolite of prostaglandin F2 alpha (PGFM), estrone (E1) and estrone sulphate (E1S) in maternal arterial plasma (MP) and amniotic fluid (AF), the prepartum progesterone (P4) decline in MP, and the evolution o...
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Veröffentlicht in: | Biology of reproduction 1990-09, Vol.43 (3), p.466-471 |
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container_title | Biology of reproduction |
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creator | Janszen, B.P.M. (University of Utrecht, Utrecht, The Netherlands) Knijn, H Weyden, G.C. van der Bevers, M.M Dieleman, S.J Taverne, M.A.M |
description | The temporal relationship among changes of the concentrations of the 13,14-dihydro-15-keto metabolite of prostaglandin F2
alpha (PGFM), estrone (E1) and estrone sulphate (E1S) in maternal arterial plasma (MP) and amniotic fluid (AF), the prepartum
progesterone (P4) decline in MP, and the evolution of uterine electromyographic (EMG) activity was investigated in 6 cows.
Calving was induced by a single i.m. injection of 5 mg flumethason on Day 270 of gestation. The period under investigation
was subdivided into four consecutive periods: Period 1 covered the last 2 days before flumethason treatment; Period 2 (mean
+/- SEM duration: 16.1 +/- 2.5 h), Period 3 (8.8 +/- 1.1 h), and Period 4 (13.0 +/- 1.5 h) together included the interval
between injection and the onset of the expulsive stage of induced parturition. Each was defined by its pattern of uterine
EMG activity. During Periods 1 and 2, this activity occurred in long episodes (2-20 min; contractures) at a similar mean (+/-
SEM) frequency (0.51 +/- 0.14/h and 0.42 +/- 0.07/h, respectively). No significant differences in hormonal concentrations
in MP and AF between these two periods were detected. During Period 3, contractures nearly disappeared (freq: 0.09 +/- 0.05/h),
and in MP mean P4 levels were significantly lower and PGFM levels were significantly higher than before. Mean PGFM concentrations
in AF were not significantly changed during Period 3. Finally, during Period 4, EMG activity reappeared and a parturient EMG
pattern gradually evolved in the presence of a further significant decline of P4 levels and significant increase of PGFM concentrations
in MP. |
doi_str_mv | 10.1095/biolreprod43.3.466 |
format | Article |
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alpha (PGFM), estrone (E1) and estrone sulphate (E1S) in maternal arterial plasma (MP) and amniotic fluid (AF), the prepartum
progesterone (P4) decline in MP, and the evolution of uterine electromyographic (EMG) activity was investigated in 6 cows.
Calving was induced by a single i.m. injection of 5 mg flumethason on Day 270 of gestation. The period under investigation
was subdivided into four consecutive periods: Period 1 covered the last 2 days before flumethason treatment; Period 2 (mean
+/- SEM duration: 16.1 +/- 2.5 h), Period 3 (8.8 +/- 1.1 h), and Period 4 (13.0 +/- 1.5 h) together included the interval
between injection and the onset of the expulsive stage of induced parturition. Each was defined by its pattern of uterine
EMG activity. During Periods 1 and 2, this activity occurred in long episodes (2-20 min; contractures) at a similar mean (+/-
SEM) frequency (0.51 +/- 0.14/h and 0.42 +/- 0.07/h, respectively). No significant differences in hormonal concentrations
in MP and AF between these two periods were detected. During Period 3, contractures nearly disappeared (freq: 0.09 +/- 0.05/h),
and in MP mean P4 levels were significantly lower and PGFM levels were significantly higher than before. Mean PGFM concentrations
in AF were not significantly changed during Period 3. Finally, during Period 4, EMG activity reappeared and a parturient EMG
pattern gradually evolved in the presence of a further significant decline of P4 levels and significant increase of PGFM concentrations
in MP.</description><identifier>ISSN: 0006-3363</identifier><identifier>EISSN: 1529-7268</identifier><identifier>DOI: 10.1095/biolreprod43.3.466</identifier><identifier>PMID: 2271727</identifier><identifier>CODEN: BIREBV</identifier><language>eng</language><publisher>Madison, WI: Society for the Study of Reproduction</publisher><subject>AMNIOTIC FLUID ; Amniotic Fluid - metabolism ; Animals ; Biological and medical sciences ; BODY FLUIDS ; CARACT MICROMORFOLOGICAS DEL SUELO ; Cattle - physiology ; CICLO ESTRAL ; COWS ; CYCLE OESTRAL ; Dinoprost - analogs & derivatives ; Dinoprost - biosynthesis ; Electromyography ; ESTEROIDES ; ESTROGENOS ; ESTRONE ; Estrone - analogs & derivatives ; Estrone - metabolism ; Female ; FLUMETASONE ; Flumethasone - pharmacology ; Fundamental and applied biological sciences. Psychology ; HORMONAS SINTETICAS ; Hormone metabolism and regulation ; HORMONE SYNTHETIQUE ; Labor, Induced ; LIQUIDE BIOLOGIQUE ; LIQUIDOS CORPORALES ; MYOMETRIUM ; Myometrium - drug effects ; OESTROGENE ; OESTROGENS ; OESTROUS CYCLE ; PARTO ; PARTURITION ; PLASMA ; Pregnancy ; Pregnancy. Parturition. Lactation ; Progesterone - blood ; PROSTAGLANDINAS ; PROSTAGLANDINE ; PROSTAGLANDINS ; SOIL MICROMORPHOLOGICAL FEATURES ; STEROIDE ; STEROIDS ; SYNTHETIC HORMONES ; TRAIT MICROMORPHOLOGIQUE DU SOL ; Uterine Contraction - drug effects ; UTERO ; UTERUS ; VACA ; VACHE ; Vertebrates: reproduction</subject><ispartof>Biology of reproduction, 1990-09, Vol.43 (3), p.466-471</ispartof><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c377t-93e5211b8be84d31b80c5798016de7cb8c11c3e657b3ff312422e8b087c59b773</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19445263$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2271727$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Janszen, B.P.M. (University of Utrecht, Utrecht, The Netherlands)</creatorcontrib><creatorcontrib>Knijn, H</creatorcontrib><creatorcontrib>Weyden, G.C. van der</creatorcontrib><creatorcontrib>Bevers, M.M</creatorcontrib><creatorcontrib>Dieleman, S.J</creatorcontrib><creatorcontrib>Taverne, M.A.M</creatorcontrib><title>Flumethason-induced calving is preceded by a period of myometrial inhibition during luteolysis</title><title>Biology of reproduction</title><addtitle>Biol Reprod</addtitle><description>The temporal relationship among changes of the concentrations of the 13,14-dihydro-15-keto metabolite of prostaglandin F2
alpha (PGFM), estrone (E1) and estrone sulphate (E1S) in maternal arterial plasma (MP) and amniotic fluid (AF), the prepartum
progesterone (P4) decline in MP, and the evolution of uterine electromyographic (EMG) activity was investigated in 6 cows.
Calving was induced by a single i.m. injection of 5 mg flumethason on Day 270 of gestation. The period under investigation
was subdivided into four consecutive periods: Period 1 covered the last 2 days before flumethason treatment; Period 2 (mean
+/- SEM duration: 16.1 +/- 2.5 h), Period 3 (8.8 +/- 1.1 h), and Period 4 (13.0 +/- 1.5 h) together included the interval
between injection and the onset of the expulsive stage of induced parturition. Each was defined by its pattern of uterine
EMG activity. During Periods 1 and 2, this activity occurred in long episodes (2-20 min; contractures) at a similar mean (+/-
SEM) frequency (0.51 +/- 0.14/h and 0.42 +/- 0.07/h, respectively). No significant differences in hormonal concentrations
in MP and AF between these two periods were detected. During Period 3, contractures nearly disappeared (freq: 0.09 +/- 0.05/h),
and in MP mean P4 levels were significantly lower and PGFM levels were significantly higher than before. Mean PGFM concentrations
in AF were not significantly changed during Period 3. Finally, during Period 4, EMG activity reappeared and a parturient EMG
pattern gradually evolved in the presence of a further significant decline of P4 levels and significant increase of PGFM concentrations
in MP.</description><subject>AMNIOTIC FLUID</subject><subject>Amniotic Fluid - metabolism</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>BODY FLUIDS</subject><subject>CARACT MICROMORFOLOGICAS DEL SUELO</subject><subject>Cattle - physiology</subject><subject>CICLO ESTRAL</subject><subject>COWS</subject><subject>CYCLE OESTRAL</subject><subject>Dinoprost - analogs & derivatives</subject><subject>Dinoprost - biosynthesis</subject><subject>Electromyography</subject><subject>ESTEROIDES</subject><subject>ESTROGENOS</subject><subject>ESTRONE</subject><subject>Estrone - analogs & derivatives</subject><subject>Estrone - metabolism</subject><subject>Female</subject><subject>FLUMETASONE</subject><subject>Flumethasone - pharmacology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>HORMONAS SINTETICAS</subject><subject>Hormone metabolism and regulation</subject><subject>HORMONE SYNTHETIQUE</subject><subject>Labor, Induced</subject><subject>LIQUIDE BIOLOGIQUE</subject><subject>LIQUIDOS CORPORALES</subject><subject>MYOMETRIUM</subject><subject>Myometrium - drug effects</subject><subject>OESTROGENE</subject><subject>OESTROGENS</subject><subject>OESTROUS CYCLE</subject><subject>PARTO</subject><subject>PARTURITION</subject><subject>PLASMA</subject><subject>Pregnancy</subject><subject>Pregnancy. Parturition. Lactation</subject><subject>Progesterone - blood</subject><subject>PROSTAGLANDINAS</subject><subject>PROSTAGLANDINE</subject><subject>PROSTAGLANDINS</subject><subject>SOIL MICROMORPHOLOGICAL FEATURES</subject><subject>STEROIDE</subject><subject>STEROIDS</subject><subject>SYNTHETIC HORMONES</subject><subject>TRAIT MICROMORPHOLOGIQUE DU SOL</subject><subject>Uterine Contraction - drug effects</subject><subject>UTERO</subject><subject>UTERUS</subject><subject>VACA</subject><subject>VACHE</subject><subject>Vertebrates: reproduction</subject><issn>0006-3363</issn><issn>1529-7268</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkMFq3DAQhkVoSTdpXyBQ0KW9eStpbEs-ltA0hUAPTa4RkjzeVZCtrWRn2bevwi5NThIz__8NfIRccbbmrGu-WR9Dwl2KfQ1rWNdte0ZWvBFdJUWr3pEVY6ytAFr4QC5yfmKM1yDgnJwLIbkUckUeb8Iy4rw1OU6Vn_rFYU-dCc9-2lCf6S5hmZSZPVBDd5h87Gkc6HiIpZa8CdRPW2_97ONE-yW99MIyYwyH7PNH8n4wIeOn03tJHm5-3F_fVne_f_66_n5XOZByrjrARnBulUVV91A-zDWyU4y3PUpnlePcAbaNtDAMwEUtBCrLlHRNZ6WES_L1yC0y_i6YZz367DAEM2Fcslas4JkSJSiOQZdizgkHvUt-NOmgOdMvUvVbqRp0kVpKn0_0xY7Y_6-cLJb9l9Pe5OJuSGZyPr-Su7puRAuvua3fbPc-oc6jCaFQQe_3-zf3ro65wURtNqmwHv50nLWKSfgHVBqYsw</recordid><startdate>19900901</startdate><enddate>19900901</enddate><creator>Janszen, B.P.M. (University of Utrecht, Utrecht, The Netherlands)</creator><creator>Knijn, H</creator><creator>Weyden, G.C. van der</creator><creator>Bevers, M.M</creator><creator>Dieleman, S.J</creator><creator>Taverne, M.A.M</creator><general>Society for the Study of Reproduction</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19900901</creationdate><title>Flumethason-induced calving is preceded by a period of myometrial inhibition during luteolysis</title><author>Janszen, B.P.M. (University of Utrecht, Utrecht, The Netherlands) ; Knijn, H ; Weyden, G.C. van der ; Bevers, M.M ; Dieleman, S.J ; Taverne, M.A.M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c377t-93e5211b8be84d31b80c5798016de7cb8c11c3e657b3ff312422e8b087c59b773</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>AMNIOTIC FLUID</topic><topic>Amniotic Fluid - metabolism</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>BODY FLUIDS</topic><topic>CARACT MICROMORFOLOGICAS DEL SUELO</topic><topic>Cattle - physiology</topic><topic>CICLO ESTRAL</topic><topic>COWS</topic><topic>CYCLE OESTRAL</topic><topic>Dinoprost - analogs & derivatives</topic><topic>Dinoprost - biosynthesis</topic><topic>Electromyography</topic><topic>ESTEROIDES</topic><topic>ESTROGENOS</topic><topic>ESTRONE</topic><topic>Estrone - analogs & derivatives</topic><topic>Estrone - metabolism</topic><topic>Female</topic><topic>FLUMETASONE</topic><topic>Flumethasone - pharmacology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>HORMONAS SINTETICAS</topic><topic>Hormone metabolism and regulation</topic><topic>HORMONE SYNTHETIQUE</topic><topic>Labor, Induced</topic><topic>LIQUIDE BIOLOGIQUE</topic><topic>LIQUIDOS CORPORALES</topic><topic>MYOMETRIUM</topic><topic>Myometrium - drug effects</topic><topic>OESTROGENE</topic><topic>OESTROGENS</topic><topic>OESTROUS CYCLE</topic><topic>PARTO</topic><topic>PARTURITION</topic><topic>PLASMA</topic><topic>Pregnancy</topic><topic>Pregnancy. Parturition. Lactation</topic><topic>Progesterone - blood</topic><topic>PROSTAGLANDINAS</topic><topic>PROSTAGLANDINE</topic><topic>PROSTAGLANDINS</topic><topic>SOIL MICROMORPHOLOGICAL FEATURES</topic><topic>STEROIDE</topic><topic>STEROIDS</topic><topic>SYNTHETIC HORMONES</topic><topic>TRAIT MICROMORPHOLOGIQUE DU SOL</topic><topic>Uterine Contraction - drug effects</topic><topic>UTERO</topic><topic>UTERUS</topic><topic>VACA</topic><topic>VACHE</topic><topic>Vertebrates: reproduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Janszen, B.P.M. (University of Utrecht, Utrecht, The Netherlands)</creatorcontrib><creatorcontrib>Knijn, H</creatorcontrib><creatorcontrib>Weyden, G.C. van der</creatorcontrib><creatorcontrib>Bevers, M.M</creatorcontrib><creatorcontrib>Dieleman, S.J</creatorcontrib><creatorcontrib>Taverne, M.A.M</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biology of reproduction</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Janszen, B.P.M. (University of Utrecht, Utrecht, The Netherlands)</au><au>Knijn, H</au><au>Weyden, G.C. van der</au><au>Bevers, M.M</au><au>Dieleman, S.J</au><au>Taverne, M.A.M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Flumethason-induced calving is preceded by a period of myometrial inhibition during luteolysis</atitle><jtitle>Biology of reproduction</jtitle><addtitle>Biol Reprod</addtitle><date>1990-09-01</date><risdate>1990</risdate><volume>43</volume><issue>3</issue><spage>466</spage><epage>471</epage><pages>466-471</pages><issn>0006-3363</issn><eissn>1529-7268</eissn><coden>BIREBV</coden><abstract>The temporal relationship among changes of the concentrations of the 13,14-dihydro-15-keto metabolite of prostaglandin F2
alpha (PGFM), estrone (E1) and estrone sulphate (E1S) in maternal arterial plasma (MP) and amniotic fluid (AF), the prepartum
progesterone (P4) decline in MP, and the evolution of uterine electromyographic (EMG) activity was investigated in 6 cows.
Calving was induced by a single i.m. injection of 5 mg flumethason on Day 270 of gestation. The period under investigation
was subdivided into four consecutive periods: Period 1 covered the last 2 days before flumethason treatment; Period 2 (mean
+/- SEM duration: 16.1 +/- 2.5 h), Period 3 (8.8 +/- 1.1 h), and Period 4 (13.0 +/- 1.5 h) together included the interval
between injection and the onset of the expulsive stage of induced parturition. Each was defined by its pattern of uterine
EMG activity. During Periods 1 and 2, this activity occurred in long episodes (2-20 min; contractures) at a similar mean (+/-
SEM) frequency (0.51 +/- 0.14/h and 0.42 +/- 0.07/h, respectively). No significant differences in hormonal concentrations
in MP and AF between these two periods were detected. During Period 3, contractures nearly disappeared (freq: 0.09 +/- 0.05/h),
and in MP mean P4 levels were significantly lower and PGFM levels were significantly higher than before. Mean PGFM concentrations
in AF were not significantly changed during Period 3. Finally, during Period 4, EMG activity reappeared and a parturient EMG
pattern gradually evolved in the presence of a further significant decline of P4 levels and significant increase of PGFM concentrations
in MP.</abstract><cop>Madison, WI</cop><pub>Society for the Study of Reproduction</pub><pmid>2271727</pmid><doi>10.1095/biolreprod43.3.466</doi><tpages>6</tpages></addata></record> |
fulltext | fulltext |
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ispartof | Biology of reproduction, 1990-09, Vol.43 (3), p.466-471 |
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language | eng |
recordid | cdi_proquest_miscellaneous_80211082 |
source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
subjects | AMNIOTIC FLUID Amniotic Fluid - metabolism Animals Biological and medical sciences BODY FLUIDS CARACT MICROMORFOLOGICAS DEL SUELO Cattle - physiology CICLO ESTRAL COWS CYCLE OESTRAL Dinoprost - analogs & derivatives Dinoprost - biosynthesis Electromyography ESTEROIDES ESTROGENOS ESTRONE Estrone - analogs & derivatives Estrone - metabolism Female FLUMETASONE Flumethasone - pharmacology Fundamental and applied biological sciences. Psychology HORMONAS SINTETICAS Hormone metabolism and regulation HORMONE SYNTHETIQUE Labor, Induced LIQUIDE BIOLOGIQUE LIQUIDOS CORPORALES MYOMETRIUM Myometrium - drug effects OESTROGENE OESTROGENS OESTROUS CYCLE PARTO PARTURITION PLASMA Pregnancy Pregnancy. Parturition. Lactation Progesterone - blood PROSTAGLANDINAS PROSTAGLANDINE PROSTAGLANDINS SOIL MICROMORPHOLOGICAL FEATURES STEROIDE STEROIDS SYNTHETIC HORMONES TRAIT MICROMORPHOLOGIQUE DU SOL Uterine Contraction - drug effects UTERO UTERUS VACA VACHE Vertebrates: reproduction |
title | Flumethason-induced calving is preceded by a period of myometrial inhibition during luteolysis |
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