Non-peptide angiotensin II receptor antagonists discriminate subtypes of 125I-angiotensin II binding sites in the rat brain
We have utilized quantitative autoradiography to define subtypes of 125I-angiotensin II (AII) binding in rat brain. AII-1 binding (displaced by DuP 753) was found in the nucleus of the solitary tract and the hypothalamus, while AII-2 binding (displaced by WL 19) was found in the thalamus and lateral...
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| Veröffentlicht in: | European journal of pharmacology 1990-10, Vol.187 (1), p.123-126 |
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| container_end_page | 126 |
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| container_title | European journal of pharmacology |
| container_volume | 187 |
| creator | Gehlert, Donald R. Gackenheimer, Susan L. Reel, Jon K. Ho-Shen Lin Steinberg, Mitchell I. |
| description | We have utilized quantitative autoradiography to define subtypes of
125I-angiotensin II (AII) binding in rat brain. AII-1 binding (displaced by DuP 753) was found in the nucleus of the solitary tract and the hypothalamus, while AII-2 binding (displaced by WL 19) was found in the thalamus and lateral septum. These results indicate that subtypes of the AII receptor are present in the brain and the AII-1 receptor subtype is present in regions consistant with the known actions of angiotensin. |
| doi_str_mv | 10.1016/0014-2999(90)90348-A |
| format | Article |
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125I-angiotensin II (AII) binding in rat brain. AII-1 binding (displaced by DuP 753) was found in the nucleus of the solitary tract and the hypothalamus, while AII-2 binding (displaced by WL 19) was found in the thalamus and lateral septum. These results indicate that subtypes of the AII receptor are present in the brain and the AII-1 receptor subtype is present in regions consistant with the known actions of angiotensin.</description><subject>Angiotensin II - antagonists & inhibitors</subject><subject>Angiotensin II - metabolism</subject><subject>Angiotensin II binding sites (subtypes)</subject><subject>Angiotensin Receptor Antagonists</subject><subject>Animals</subject><subject>Autoradiography</subject><subject>Binding, Competitive - drug effects</subject><subject>Biochemistry and metabolism</subject><subject>Biological and medical sciences</subject><subject>Brain</subject><subject>Brain - anatomy & histology</subject><subject>Brain Chemistry - drug effects</subject><subject>Central nervous system</subject><subject>DuP 753</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hypothalamus - anatomy & histology</subject><subject>Hypothalamus - metabolism</subject><subject>Imidazoles - pharmacology</subject><subject>Iodine Radioisotopes</subject><subject>Losartan</subject><subject>Male</subject><subject>Medulla Oblongata - anatomy & histology</subject><subject>Medulla Oblongata - metabolism</subject><subject>Pyridines - pharmacology</subject><subject>Rat</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Receptors, Angiotensin - drug effects</subject><subject>Tetrazoles - pharmacology</subject><subject>Vertebrates: nervous system and sense organs</subject><subject>WL 19</subject><issn>0014-2999</issn><issn>1879-0712</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU2LFDEQhoMo67j6DxRyUfTQWkkn3Z3LwrD4MbDoRc8hna4eIzNJm8oIi3_ezM6wggdPgaqnXlJPMfZcwFsBonsHIFQjjTGvDbwx0KqhWT9gKzH0poFeyIdsdY88Zk-IfgCANlJfsAspe9kqs2K_P6fYLLiUMCF3cRtSwUgh8s2GZ_S1kXKtF7dNMVAhPgXyOexDdAU5HcZyuyDxNHMh9ab5J2EMcQpxyymUCtVa-Y48u8LH7EJ8yh7Nbkf47Pxesm8f3n-9_tTcfPm4uV7fNL4FME2rJbbYqXk0vlddL7zuNfZD55zSegQY9DjMpvMTdL1WbpBaI-Iwj61Cr0R7yV6dcpecfh6Qit3XJXC3cxHTgewAUoC8A9UJ9DkRZZztUld1-dYKsEfn9ijUHoVaA_bOuV3XsRfn_MO4x-l-6Cy59l-e-468283ZRR_ob7aRRtXDVO7qxGGV8StgtuQDRo9TqKcodkrh_x_5A3-ongI</recordid><startdate>19901002</startdate><enddate>19901002</enddate><creator>Gehlert, Donald R.</creator><creator>Gackenheimer, Susan L.</creator><creator>Reel, Jon K.</creator><creator>Ho-Shen Lin</creator><creator>Steinberg, Mitchell I.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19901002</creationdate><title>Non-peptide angiotensin II receptor antagonists discriminate subtypes of 125I-angiotensin II binding sites in the rat brain</title><author>Gehlert, Donald R. ; Gackenheimer, Susan L. ; Reel, Jon K. ; Ho-Shen Lin ; Steinberg, Mitchell I.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3009-352e3e64fb9c74671c575e786aa455b0085b8f96cd06754a8255eee8fb34ec413</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Angiotensin II - antagonists & inhibitors</topic><topic>Angiotensin II - metabolism</topic><topic>Angiotensin II binding sites (subtypes)</topic><topic>Angiotensin Receptor Antagonists</topic><topic>Animals</topic><topic>Autoradiography</topic><topic>Binding, Competitive - drug effects</topic><topic>Biochemistry and metabolism</topic><topic>Biological and medical sciences</topic><topic>Brain</topic><topic>Brain - anatomy & histology</topic><topic>Brain Chemistry - drug effects</topic><topic>Central nervous system</topic><topic>DuP 753</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hypothalamus - anatomy & histology</topic><topic>Hypothalamus - metabolism</topic><topic>Imidazoles - pharmacology</topic><topic>Iodine Radioisotopes</topic><topic>Losartan</topic><topic>Male</topic><topic>Medulla Oblongata - anatomy & histology</topic><topic>Medulla Oblongata - metabolism</topic><topic>Pyridines - pharmacology</topic><topic>Rat</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Receptors, Angiotensin - drug effects</topic><topic>Tetrazoles - pharmacology</topic><topic>Vertebrates: nervous system and sense organs</topic><topic>WL 19</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gehlert, Donald R.</creatorcontrib><creatorcontrib>Gackenheimer, Susan L.</creatorcontrib><creatorcontrib>Reel, Jon K.</creatorcontrib><creatorcontrib>Ho-Shen Lin</creatorcontrib><creatorcontrib>Steinberg, Mitchell I.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gehlert, Donald R.</au><au>Gackenheimer, Susan L.</au><au>Reel, Jon K.</au><au>Ho-Shen Lin</au><au>Steinberg, Mitchell I.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Non-peptide angiotensin II receptor antagonists discriminate subtypes of 125I-angiotensin II binding sites in the rat brain</atitle><jtitle>European journal of pharmacology</jtitle><addtitle>Eur J Pharmacol</addtitle><date>1990-10-02</date><risdate>1990</risdate><volume>187</volume><issue>1</issue><spage>123</spage><epage>126</epage><pages>123-126</pages><issn>0014-2999</issn><eissn>1879-0712</eissn><coden>EJPHAZ</coden><abstract>We have utilized quantitative autoradiography to define subtypes of
125I-angiotensin II (AII) binding in rat brain. AII-1 binding (displaced by DuP 753) was found in the nucleus of the solitary tract and the hypothalamus, while AII-2 binding (displaced by WL 19) was found in the thalamus and lateral septum. These results indicate that subtypes of the AII receptor are present in the brain and the AII-1 receptor subtype is present in regions consistant with the known actions of angiotensin.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>2272349</pmid><doi>10.1016/0014-2999(90)90348-A</doi><tpages>4</tpages></addata></record> |
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| ispartof | European journal of pharmacology, 1990-10, Vol.187 (1), p.123-126 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Angiotensin II - antagonists & inhibitors Angiotensin II - metabolism Angiotensin II binding sites (subtypes) Angiotensin Receptor Antagonists Animals Autoradiography Binding, Competitive - drug effects Biochemistry and metabolism Biological and medical sciences Brain Brain - anatomy & histology Brain Chemistry - drug effects Central nervous system DuP 753 Fundamental and applied biological sciences. Psychology Hypothalamus - anatomy & histology Hypothalamus - metabolism Imidazoles - pharmacology Iodine Radioisotopes Losartan Male Medulla Oblongata - anatomy & histology Medulla Oblongata - metabolism Pyridines - pharmacology Rat Rats Rats, Inbred Strains Receptors, Angiotensin - drug effects Tetrazoles - pharmacology Vertebrates: nervous system and sense organs WL 19 |
| title | Non-peptide angiotensin II receptor antagonists discriminate subtypes of 125I-angiotensin II binding sites in the rat brain |
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