Non-peptide angiotensin II receptor antagonists discriminate subtypes of 125I-angiotensin II binding sites in the rat brain

We have utilized quantitative autoradiography to define subtypes of 125I-angiotensin II (AII) binding in rat brain. AII-1 binding (displaced by DuP 753) was found in the nucleus of the solitary tract and the hypothalamus, while AII-2 binding (displaced by WL 19) was found in the thalamus and lateral...

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Veröffentlicht in:	European journal of pharmacology 1990-10, Vol.187 (1), p.123-126
Hauptverfasser:	Gehlert, Donald R., Gackenheimer, Susan L., Reel, Jon K., Ho-Shen Lin, Steinberg, Mitchell I.
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin II - antagonists & inhibitors Angiotensin II - metabolism Angiotensin II binding sites (subtypes) Angiotensin Receptor Antagonists Animals Autoradiography Binding, Competitive - drug effects Biochemistry and metabolism Biological and medical sciences Brain Brain - anatomy & histology Brain Chemistry - drug effects Central nervous system DuP 753 Fundamental and applied biological sciences. Psychology Hypothalamus - anatomy & histology Hypothalamus - metabolism Imidazoles - pharmacology Iodine Radioisotopes Losartan Male Medulla Oblongata - anatomy & histology Medulla Oblongata - metabolism Pyridines - pharmacology Rat Rats Rats, Inbred Strains Receptors, Angiotensin - drug effects Tetrazoles - pharmacology Vertebrates: nervous system and sense organs WL 19
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Zusammenfassung:	We have utilized quantitative autoradiography to define subtypes of 125I-angiotensin II (AII) binding in rat brain. AII-1 binding (displaced by DuP 753) was found in the nucleus of the solitary tract and the hypothalamus, while AII-2 binding (displaced by WL 19) was found in the thalamus and lateral septum. These results indicate that subtypes of the AII receptor are present in the brain and the AII-1 receptor subtype is present in regions consistant with the known actions of angiotensin.
ISSN:	0014-2999 1879-0712
DOI:	10.1016/0014-2999(90)90348-A