Cellular localization of Na +, K +-ATPase in the mammalian cochlear duct: Significance for cochlear fluid balance

Cytochemical and autoradiographic procedures were employed to determine the cellular distribution of Na +, K +-ATPase in the guinea pig cochlea. The highest activity was associated with the stria vascularis and was restricted almost entirely to the contraluminal extensions of the marginal cells. Ele...

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Veröffentlicht in:	American journal of otolaryngology 1982-09, Vol.3 (5), p.332-338
Hauptverfasser:	Kerr, Thomas P., Ross, Muriel D., Ernst, Stephen A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Transport, Active Cell Membrane - enzymology Cochlea Cochlea - enzymology Cochlear Duct - enzymology Cochlear Duct - ultrastructure Endolymph - physiology Guinea Pigs Ion Channels - metabolism Microscopy, Electron Na + K +-ATPase Ouabain Sodium-Potassium-Exchanging ATPase - analysis Sodium-Potassium-Exchanging ATPase - physiology Space life sciences Stria Vascularis - enzymology Stria Vascularis - ultrastructure Water-Electrolyte Balance
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container_end_page	338
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container_title	American journal of otolaryngology
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creator	Kerr, Thomas P. Ross, Muriel D. Ernst, Stephen A.
description	Cytochemical and autoradiographic procedures were employed to determine the cellular distribution of Na +, K +-ATPase in the guinea pig cochlea. The highest activity was associated with the stria vascularis and was restricted almost entirely to the contraluminal extensions of the marginal cells. Elevated levels of activity were also observed in stromal cells of the spiral prominence, external sulcus, and spiral limbus. The pattern of activity in the latter tissues was unusual in being symmetrically distributed along the plasma membranes of the reactive cells. In the organ of Corti, only neural elements showed appreciable activity. Possible functions of the enzyme are discussed in relation to cochlear fluid balance.
doi_str_mv	10.1016/S0196-0709(82)80006-9
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The highest activity was associated with the stria vascularis and was restricted almost entirely to the contraluminal extensions of the marginal cells. Elevated levels of activity were also observed in stromal cells of the spiral prominence, external sulcus, and spiral limbus. The pattern of activity in the latter tissues was unusual in being symmetrically distributed along the plasma membranes of the reactive cells. In the organ of Corti, only neural elements showed appreciable activity. 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The highest activity was associated with the stria vascularis and was restricted almost entirely to the contraluminal extensions of the marginal cells. Elevated levels of activity were also observed in stromal cells of the spiral prominence, external sulcus, and spiral limbus. The pattern of activity in the latter tissues was unusual in being symmetrically distributed along the plasma membranes of the reactive cells. In the organ of Corti, only neural elements showed appreciable activity. Possible functions of the enzyme are discussed in relation to cochlear fluid balance.</description><subject>Animals</subject><subject>Biological Transport, Active</subject><subject>Cell Membrane - enzymology</subject><subject>Cochlea</subject><subject>Cochlea - enzymology</subject><subject>Cochlear Duct - enzymology</subject><subject>Cochlear Duct - ultrastructure</subject><subject>Endolymph - physiology</subject><subject>Guinea Pigs</subject><subject>Ion Channels - metabolism</subject><subject>Microscopy, Electron</subject><subject>Na + K +-ATPase</subject><subject>Ouabain</subject><subject>Sodium-Potassium-Exchanging ATPase - analysis</subject><subject>Sodium-Potassium-Exchanging ATPase - physiology</subject><subject>Space life sciences</subject><subject>Stria Vascularis - enzymology</subject><subject>Stria Vascularis - ultrastructure</subject><subject>Water-Electrolyte Balance</subject><issn>0196-0709</issn><issn>1532-818X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1982</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkF1rFTEQhoMo7bH6Ewq5KkpdnU32I_FGysEvLFVoC70L2WTSpmQ3bbIr6K9vTs-hXno1F-_zzjAPIYc1vK-h7j6cQy27CnqQbwR7KwCgq-QzsqpbzipRi6vnZPWE7JOXOd8Whje83SN7HZOcM7ki92sMYQk60RCNDv6vnn2caHT0TNPjd_QHPa5OLn7pjNRPdL5BOupxLKCeqInmJmCp2sXMH-m5v56880ZPBqmL6V_uwuItHXTYRK_IC6dDxte7eUAuv3y-WH-rTn9-_b4-Oa1Mw7q5Mn3PmJWiNa10A_S8r0EYBBhQNI2VkoPtWtk4y3rRMC46jQI5t22nHR-AH5Cj7d67FO8XzLMafTblWz1hXLISwKAsaQvYbkGTYs4JnbpLftTpj6pBbVSrR9Vq41EJph5VK1l6h7sDyzCifWrt3Jb80zbH8uVvj0ll47EYsD6hmZWN_j8XHgAQMYyZ</recordid><startdate>198209</startdate><enddate>198209</enddate><creator>Kerr, Thomas P.</creator><creator>Ross, Muriel D.</creator><creator>Ernst, Stephen A.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>8BM</scope></search><sort><creationdate>198209</creationdate><title>Cellular localization of Na +, K +-ATPase in the mammalian cochlear duct: Significance for cochlear fluid balance</title><author>Kerr, Thomas P. ; Ross, Muriel D. ; Ernst, Stephen A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c426t-c7722d985c59fb0737108ce00be844d9930d6594fd27842386ae8e33d56af3b03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1982</creationdate><topic>Animals</topic><topic>Biological Transport, Active</topic><topic>Cell Membrane - enzymology</topic><topic>Cochlea</topic><topic>Cochlea - enzymology</topic><topic>Cochlear Duct - enzymology</topic><topic>Cochlear Duct - ultrastructure</topic><topic>Endolymph - physiology</topic><topic>Guinea Pigs</topic><topic>Ion Channels - metabolism</topic><topic>Microscopy, Electron</topic><topic>Na + K +-ATPase</topic><topic>Ouabain</topic><topic>Sodium-Potassium-Exchanging ATPase - analysis</topic><topic>Sodium-Potassium-Exchanging ATPase - physiology</topic><topic>Space life sciences</topic><topic>Stria Vascularis - enzymology</topic><topic>Stria Vascularis - ultrastructure</topic><topic>Water-Electrolyte Balance</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kerr, Thomas P.</creatorcontrib><creatorcontrib>Ross, Muriel D.</creatorcontrib><creatorcontrib>Ernst, Stephen A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>ComDisDome</collection><jtitle>American journal of otolaryngology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kerr, Thomas P.</au><au>Ross, Muriel D.</au><au>Ernst, Stephen A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cellular localization of Na +, K +-ATPase in the mammalian cochlear duct: Significance for cochlear fluid balance</atitle><jtitle>American journal of otolaryngology</jtitle><addtitle>Am J Otolaryngol</addtitle><date>1982-09</date><risdate>1982</risdate><volume>3</volume><issue>5</issue><spage>332</spage><epage>338</epage><pages>332-338</pages><issn>0196-0709</issn><eissn>1532-818X</eissn><abstract>Cytochemical and autoradiographic procedures were employed to determine the cellular distribution of Na +, K +-ATPase in the guinea pig cochlea. The highest activity was associated with the stria vascularis and was restricted almost entirely to the contraluminal extensions of the marginal cells. Elevated levels of activity were also observed in stromal cells of the spiral prominence, external sulcus, and spiral limbus. The pattern of activity in the latter tissues was unusual in being symmetrically distributed along the plasma membranes of the reactive cells. In the organ of Corti, only neural elements showed appreciable activity. Possible functions of the enzyme are discussed in relation to cochlear fluid balance.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>6293329</pmid><doi>10.1016/S0196-0709(82)80006-9</doi><tpages>7</tpages></addata></record>
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source	MEDLINE; ScienceDirect Journals (5 years ago - present)
subjects	Animals Biological Transport, Active Cell Membrane - enzymology Cochlea Cochlea - enzymology Cochlear Duct - enzymology Cochlear Duct - ultrastructure Endolymph - physiology Guinea Pigs Ion Channels - metabolism Microscopy, Electron Na + K +-ATPase Ouabain Sodium-Potassium-Exchanging ATPase - analysis Sodium-Potassium-Exchanging ATPase - physiology Space life sciences Stria Vascularis - enzymology Stria Vascularis - ultrastructure Water-Electrolyte Balance
title	Cellular localization of Na +, K +-ATPase in the mammalian cochlear duct: Significance for cochlear fluid balance
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