Chemokinetic activity of N-formyl-methionyl-leucyl-phenylalanine on human neutrophils, and its modulation by phenylbutazone

Phenylbutazone (PBZ) is known to inhibit the oriented migration of human polymorphonuclear leukocytes (PMNs) induced by formyl-methionyl-leucyl-phenylalanine (FMLP), and to protect these cells against the deactivation caused by their prior incubation with FMLP. To gain insight into the mechanism of...

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Veröffentlicht in:	Biochemical pharmacology 1982-10, Vol.31 (19), p.3071-3076
Hauptverfasser:	Perianin, Axel, Labro, Marie-Thérèse, Hakim, Jacques
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemotaxis, Leukocyte - drug effects Humans Kinetics Klebsiella pneumoniae - drug effects Methionine - analogs & derivatives N-Formylmethionine - analogs & derivatives N-Formylmethionine - antagonists & inhibitors N-Formylmethionine - pharmacology N-Formylmethionine Leucyl-Phenylalanine Neutrophils - drug effects Oligopeptides - antagonists & inhibitors Oligopeptides - pharmacology Phenylbutazone - pharmacology Zymosan - pharmacology
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