Epoxidation of cholesterol by hepatic microsomal lipid hydroperoxides

[1,2-3H]Cholesterol was epoxidized to radioactive cholesterol α- and β-epoxides (5,6α-epoxy-5α- and 5,6β-epoxy-5β-cholestan-3β-ols) in the ratio 1:4 by hepatic microsomal lipid hydroperoxides (MsOOH, 1 mM as active oxygen) in the presence of ferrous ion. MsOOH could be replaced by methyl linoleate h...

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Veröffentlicht in:	Biochemical and biophysical research communications 1982-09, Vol.108 (2), p.724-730
Hauptverfasser:	Watabe, Tadashi, Isobe, Masakazu, Tsubaki, Atsushi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cholesterol - analogs & derivatives Cholesterol - biosynthesis Cholesterol - metabolism Ferrous Compounds - pharmacology In Vitro Techniques Lipid Metabolism Male Microsomes, Liver - drug effects Microsomes, Liver - metabolism Peroxides - metabolism Rats Rats, Inbred Strains
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