Photodynamic therapy of esophageal carcinoma
Photodynamic therapy (PDT) utilizing either hematoporphyrin derivative or Photofrin II is proving to be an effective modality in the treatment of early superficial (ES) or advanced invasive (AI) carcinoma of the esophagus. An argon-pumped dye laser was used to deliver 630 nm light via quartz fibers...
Gespeichert in:
| Veröffentlicht in: | Surgical endoscopy 1990-10, Vol.4 (3), p.150-153 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 153 |
|---|---|
| container_issue | 3 |
| container_start_page | 150 |
| container_title | Surgical endoscopy |
| container_volume | 4 |
| creator | OKUNAKA, T KATO, H CONAKA, C YAMAMOTO, H BONAMINIO, A ECKHAUSER, M. L |
| description | Photodynamic therapy (PDT) utilizing either hematoporphyrin derivative or Photofrin II is proving to be an effective modality in the treatment of early superficial (ES) or advanced invasive (AI) carcinoma of the esophagus. An argon-pumped dye laser was used to deliver 630 nm light via quartz fibers passed through the biopsy channel of a gastroscope after intravenous injection of photosensitizer. Between 1982 and 1989, 20 patients (ES = 6; AI = 14) were treated in this manner. Complete remission was obtained in 4 of 6 ES cases, and the mean survival after PDT alone or in combination with other therapy was 27 months. Five patients remain alive to date. In the AI group, significant remissions were obtained in 6 cases while partial remissions were observed in another 8. The mean dysphagia grade improved from 4.0 to 2.8. We conclude that PDT is efficacious in the treatment of ES esophageal cancer, where complete remission may be achieved, and as palliative therapy in advanced cases to alleviate dysphagia. |
| doi_str_mv | 10.1007/bf02336594 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_80202988</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>80202988</sourcerecordid><originalsourceid>FETCH-LOGICAL-c378t-73b0c83d1ca50c59ae434f6a928e1f232213f0198070f4fe2be151aa260c8713</originalsourceid><addsrcrecordid>eNpFkD1PwzAURS0EKqWwsCNlgQEReP5IbI-looBUCYbu0Ytr06AkDnY69N8T1ADTG-65R0-XkEsK9xRAPpQOGOd5psURmVLBWcoYVcdkCppDyqQWp-Qsxk8AEJpmEzJhLJe5kFNy9771vd_sW2wqk_RbG7DbJ94lNvpuix8W68RgMFXrGzwnJw7raC_GOyPr5dN68ZKu3p5fF_NVarhUfSp5CUbxDTWYgck0WsGFy1EzZaljfHiOO6BagQQnnGWlpRlFZPlQk5TPyM1B2wX_tbOxL5oqGlvX2Fq_i4UCBkwrNYC3B9AEH2OwruhC1WDYFxSKn2WKx-XvMgN8NVp3ZWM3f-g4xZBfjzlGg7UL2Joq_hu1yHKRZ_wbS8Jo7g</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>80202988</pqid></control><display><type>article</type><title>Photodynamic therapy of esophageal carcinoma</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>OKUNAKA, T ; KATO, H ; CONAKA, C ; YAMAMOTO, H ; BONAMINIO, A ; ECKHAUSER, M. L</creator><creatorcontrib>OKUNAKA, T ; KATO, H ; CONAKA, C ; YAMAMOTO, H ; BONAMINIO, A ; ECKHAUSER, M. L</creatorcontrib><description>Photodynamic therapy (PDT) utilizing either hematoporphyrin derivative or Photofrin II is proving to be an effective modality in the treatment of early superficial (ES) or advanced invasive (AI) carcinoma of the esophagus. An argon-pumped dye laser was used to deliver 630 nm light via quartz fibers passed through the biopsy channel of a gastroscope after intravenous injection of photosensitizer. Between 1982 and 1989, 20 patients (ES = 6; AI = 14) were treated in this manner. Complete remission was obtained in 4 of 6 ES cases, and the mean survival after PDT alone or in combination with other therapy was 27 months. Five patients remain alive to date. In the AI group, significant remissions were obtained in 6 cases while partial remissions were observed in another 8. The mean dysphagia grade improved from 4.0 to 2.8. We conclude that PDT is efficacious in the treatment of ES esophageal cancer, where complete remission may be achieved, and as palliative therapy in advanced cases to alleviate dysphagia.</description><identifier>ISSN: 0930-2794</identifier><identifier>EISSN: 1432-2218</identifier><identifier>DOI: 10.1007/bf02336594</identifier><identifier>PMID: 2267647</identifier><identifier>CODEN: SUREEX</identifier><language>eng</language><publisher>New York, NY: Springer</publisher><subject>Aged ; Aged, 80 and over ; Biological and medical sciences ; Carcinoma, Squamous Cell - drug therapy ; Carcinoma, Squamous Cell - mortality ; Carcinoma, Squamous Cell - pathology ; Esophageal Neoplasms - drug therapy ; Esophageal Neoplasms - mortality ; Esophageal Neoplasms - pathology ; Esophagus ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Gastroscopy ; Humans ; Lasers ; Male ; Medical sciences ; Middle Aged ; Photochemotherapy - methods ; Survival Rate ; Tumors</subject><ispartof>Surgical endoscopy, 1990-10, Vol.4 (3), p.150-153</ispartof><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c378t-73b0c83d1ca50c59ae434f6a928e1f232213f0198070f4fe2be151aa260c8713</citedby><cites>FETCH-LOGICAL-c378t-73b0c83d1ca50c59ae434f6a928e1f232213f0198070f4fe2be151aa260c8713</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19456465$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2267647$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>OKUNAKA, T</creatorcontrib><creatorcontrib>KATO, H</creatorcontrib><creatorcontrib>CONAKA, C</creatorcontrib><creatorcontrib>YAMAMOTO, H</creatorcontrib><creatorcontrib>BONAMINIO, A</creatorcontrib><creatorcontrib>ECKHAUSER, M. L</creatorcontrib><title>Photodynamic therapy of esophageal carcinoma</title><title>Surgical endoscopy</title><addtitle>Surg Endosc</addtitle><description>Photodynamic therapy (PDT) utilizing either hematoporphyrin derivative or Photofrin II is proving to be an effective modality in the treatment of early superficial (ES) or advanced invasive (AI) carcinoma of the esophagus. An argon-pumped dye laser was used to deliver 630 nm light via quartz fibers passed through the biopsy channel of a gastroscope after intravenous injection of photosensitizer. Between 1982 and 1989, 20 patients (ES = 6; AI = 14) were treated in this manner. Complete remission was obtained in 4 of 6 ES cases, and the mean survival after PDT alone or in combination with other therapy was 27 months. Five patients remain alive to date. In the AI group, significant remissions were obtained in 6 cases while partial remissions were observed in another 8. The mean dysphagia grade improved from 4.0 to 2.8. We conclude that PDT is efficacious in the treatment of ES esophageal cancer, where complete remission may be achieved, and as palliative therapy in advanced cases to alleviate dysphagia.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Squamous Cell - drug therapy</subject><subject>Carcinoma, Squamous Cell - mortality</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Esophageal Neoplasms - drug therapy</subject><subject>Esophageal Neoplasms - mortality</subject><subject>Esophageal Neoplasms - pathology</subject><subject>Esophagus</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Gastroscopy</subject><subject>Humans</subject><subject>Lasers</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Photochemotherapy - methods</subject><subject>Survival Rate</subject><subject>Tumors</subject><issn>0930-2794</issn><issn>1432-2218</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkD1PwzAURS0EKqWwsCNlgQEReP5IbI-looBUCYbu0Ytr06AkDnY69N8T1ADTG-65R0-XkEsK9xRAPpQOGOd5psURmVLBWcoYVcdkCppDyqQWp-Qsxk8AEJpmEzJhLJe5kFNy9771vd_sW2wqk_RbG7DbJ94lNvpuix8W68RgMFXrGzwnJw7raC_GOyPr5dN68ZKu3p5fF_NVarhUfSp5CUbxDTWYgck0WsGFy1EzZaljfHiOO6BagQQnnGWlpRlFZPlQk5TPyM1B2wX_tbOxL5oqGlvX2Fq_i4UCBkwrNYC3B9AEH2OwruhC1WDYFxSKn2WKx-XvMgN8NVp3ZWM3f-g4xZBfjzlGg7UL2Joq_hu1yHKRZ_wbS8Jo7g</recordid><startdate>19901001</startdate><enddate>19901001</enddate><creator>OKUNAKA, T</creator><creator>KATO, H</creator><creator>CONAKA, C</creator><creator>YAMAMOTO, H</creator><creator>BONAMINIO, A</creator><creator>ECKHAUSER, M. L</creator><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19901001</creationdate><title>Photodynamic therapy of esophageal carcinoma</title><author>OKUNAKA, T ; KATO, H ; CONAKA, C ; YAMAMOTO, H ; BONAMINIO, A ; ECKHAUSER, M. L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c378t-73b0c83d1ca50c59ae434f6a928e1f232213f0198070f4fe2be151aa260c8713</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Carcinoma, Squamous Cell - drug therapy</topic><topic>Carcinoma, Squamous Cell - mortality</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Esophageal Neoplasms - drug therapy</topic><topic>Esophageal Neoplasms - mortality</topic><topic>Esophageal Neoplasms - pathology</topic><topic>Esophagus</topic><topic>Female</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Gastroscopy</topic><topic>Humans</topic><topic>Lasers</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Photochemotherapy - methods</topic><topic>Survival Rate</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>OKUNAKA, T</creatorcontrib><creatorcontrib>KATO, H</creatorcontrib><creatorcontrib>CONAKA, C</creatorcontrib><creatorcontrib>YAMAMOTO, H</creatorcontrib><creatorcontrib>BONAMINIO, A</creatorcontrib><creatorcontrib>ECKHAUSER, M. L</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Surgical endoscopy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>OKUNAKA, T</au><au>KATO, H</au><au>CONAKA, C</au><au>YAMAMOTO, H</au><au>BONAMINIO, A</au><au>ECKHAUSER, M. L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Photodynamic therapy of esophageal carcinoma</atitle><jtitle>Surgical endoscopy</jtitle><addtitle>Surg Endosc</addtitle><date>1990-10-01</date><risdate>1990</risdate><volume>4</volume><issue>3</issue><spage>150</spage><epage>153</epage><pages>150-153</pages><issn>0930-2794</issn><eissn>1432-2218</eissn><coden>SUREEX</coden><abstract>Photodynamic therapy (PDT) utilizing either hematoporphyrin derivative or Photofrin II is proving to be an effective modality in the treatment of early superficial (ES) or advanced invasive (AI) carcinoma of the esophagus. An argon-pumped dye laser was used to deliver 630 nm light via quartz fibers passed through the biopsy channel of a gastroscope after intravenous injection of photosensitizer. Between 1982 and 1989, 20 patients (ES = 6; AI = 14) were treated in this manner. Complete remission was obtained in 4 of 6 ES cases, and the mean survival after PDT alone or in combination with other therapy was 27 months. Five patients remain alive to date. In the AI group, significant remissions were obtained in 6 cases while partial remissions were observed in another 8. The mean dysphagia grade improved from 4.0 to 2.8. We conclude that PDT is efficacious in the treatment of ES esophageal cancer, where complete remission may be achieved, and as palliative therapy in advanced cases to alleviate dysphagia.</abstract><cop>New York, NY</cop><pub>Springer</pub><pmid>2267647</pmid><doi>10.1007/bf02336594</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0930-2794 |
| ispartof | Surgical endoscopy, 1990-10, Vol.4 (3), p.150-153 |
| issn | 0930-2794 1432-2218 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_80202988 |
| source | MEDLINE; SpringerNature Journals |
| subjects | Aged Aged, 80 and over Biological and medical sciences Carcinoma, Squamous Cell - drug therapy Carcinoma, Squamous Cell - mortality Carcinoma, Squamous Cell - pathology Esophageal Neoplasms - drug therapy Esophageal Neoplasms - mortality Esophageal Neoplasms - pathology Esophagus Female Gastroenterology. Liver. Pancreas. Abdomen Gastroscopy Humans Lasers Male Medical sciences Middle Aged Photochemotherapy - methods Survival Rate Tumors |
| title | Photodynamic therapy of esophageal carcinoma |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-20T20%3A59%3A28IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Photodynamic%20therapy%20of%20esophageal%20carcinoma&rft.jtitle=Surgical%20endoscopy&rft.au=OKUNAKA,%20T&rft.date=1990-10-01&rft.volume=4&rft.issue=3&rft.spage=150&rft.epage=153&rft.pages=150-153&rft.issn=0930-2794&rft.eissn=1432-2218&rft.coden=SUREEX&rft_id=info:doi/10.1007/bf02336594&rft_dat=%3Cproquest_cross%3E80202988%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=80202988&rft_id=info:pmid/2267647&rfr_iscdi=true |