Genetic control of immunity to gastrointestinal nematodes of cattle
Previous studies have indicated that host genetics significantly affects the number of gastrointestinal nematode eggs per gram (epg) in the feces of calves during their first grazing season. An entire calf crop of approximately 190 animals was monitored monthly until weaning to verify these earlier...
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| Veröffentlicht in: | Veterinary parasitology 1990-11, Vol.37 (3), p.257-272 |
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| description | Previous studies have indicated that host genetics significantly affects the number of gastrointestinal nematode eggs per gram (epg) in the feces of calves during their first grazing season. An entire calf crop of approximately 190 animals was monitored monthly until weaning to verify these earlier results, and to begin to discern the basis for this phenomenon. A significant genetic effect on fecal epg values was not observed until calves had been on pasture for 2–3 months, and was demonstrable until late in the grazing season when the effect was lost. The loss of a genetic effect coincided with the appearance of significant numbers of the more highly fecund nematode species
Haemonchus placei and
Oesophagostomum radiatum, and with an apparent increase in
Ostertagia ostertagi transmission, indicating that the observed genetic control of epg values may be species specific, dose dependent or both. Calves were selected from the population, and grouped according to their epg phenotype over the grazing season as either high or low epg calves. Postmortem examination of some of these calves indicated that worm burdens in the low epg calves were 60% of those of the high epg calves. Experimental challenge inoculation of the remaining calves indicated that: (1) challenge with
Cooperia oncophora resulted in low epg calves harboring worm numbers that were 65% of those of high epg calves; (2) challenge with
O. ostertagi resulted in similar numbers of worms in both groups, but the fecundity of worms in the low epg groups was significantly lower (
P |
| doi_str_mv | 10.1016/0304-4017(90)90009-Z |
| format | Article |
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Haemonchus placei and
Oesophagostomum radiatum, and with an apparent increase in
Ostertagia ostertagi transmission, indicating that the observed genetic control of epg values may be species specific, dose dependent or both. Calves were selected from the population, and grouped according to their epg phenotype over the grazing season as either high or low epg calves. Postmortem examination of some of these calves indicated that worm burdens in the low epg calves were 60% of those of the high epg calves. Experimental challenge inoculation of the remaining calves indicated that: (1) challenge with
Cooperia oncophora resulted in low epg calves harboring worm numbers that were 65% of those of high epg calves; (2) challenge with
O. ostertagi resulted in similar numbers of worms in both groups, but the fecundity of worms in the low epg groups was significantly lower (
P<0.05) than in the high epg group. Analysis of serum anti-
Ostertagia antibody levels in the grazing calf population showed rises in serum IgG1, IgG2, IgM and IgA antibody levels during the grazing season. Peak serum IgG2 and IgG1 anti-
Ostertagia antibody levels were found to be significantly affected by host genetic factors while IgA and IgM levels were not under such control.</description><identifier>ISSN: 0304-4017</identifier><identifier>EISSN: 1873-2550</identifier><identifier>DOI: 10.1016/0304-4017(90)90009-Z</identifier><identifier>PMID: 2267727</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Animals ; Antibodies, Helminth - biosynthesis ; APPAREIL DIGESTIF ; Breeding ; CALVES ; Cattle ; Cattle Diseases - genetics ; Cattle Diseases - immunology ; Cohort Studies ; CONTROL DE NEMATODOS ; CONTROL GENETICO ; COOPERIA ONCOPHORA ; DIGESTIVE SYSTEM ; FAECES ; FECES ; Feces - parasitology ; Female ; FENOTIPOS ; GENETIC CONTROL ; HAEMONCHUS ; Haemonchus placei ; HECES ; IMMUNITE ; IMMUNITY ; Immunity, Active - genetics ; Immunoglobulins - biosynthesis ; INFECCIONES POR NEMATODOS ; INMUNIDAD ; INSPECCION POSTMORTEM ; Intestinal Diseases, Parasitic - genetics ; Intestinal Diseases, Parasitic - immunology ; Intestinal Diseases, Parasitic - veterinary ; LUTTE ANTINEMATODE ; LUTTE GENETIQUE ; Male ; NECROPSIE ; NEMATODE CONTROL ; NEMATODE INFECTIONS ; Nematode Infections - genetics ; Nematode Infections - immunology ; Nematode Infections - veterinary ; NEMATODOSE ; OESOPHAGOSTOMUM RADIATUM ; Ostertagia - immunology ; Ostertagia - isolation & purification ; OSTERTAGIA OSTERTAGI ; Ostertagiasis - genetics ; Ostertagiasis - immunology ; Ostertagiasis - veterinary ; OVA ; OVULE ; OVULO ; Parasite Egg Count - veterinary ; PHENOTYPE ; PHENOTYPES ; POSTMORTEM EXAMINATION ; SISTEMA DIGESTIVO ; TERNERO ; VEAU</subject><ispartof>Veterinary parasitology, 1990-11, Vol.37 (3), p.257-272</ispartof><rights>1990</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c458t-4294f69c061ac65ec2a11d0efca432cf16bac1e016353a773ef75d88988f57053</citedby><cites>FETCH-LOGICAL-c458t-4294f69c061ac65ec2a11d0efca432cf16bac1e016353a773ef75d88988f57053</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0304-4017(90)90009-Z$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,778,782,3539,27911,27912,45982</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2267727$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gasbarre, Louis C.</creatorcontrib><creatorcontrib>Leighton, Eldin A.</creatorcontrib><creatorcontrib>Davies, Christopher J.</creatorcontrib><title>Genetic control of immunity to gastrointestinal nematodes of cattle</title><title>Veterinary parasitology</title><addtitle>Vet Parasitol</addtitle><description>Previous studies have indicated that host genetics significantly affects the number of gastrointestinal nematode eggs per gram (epg) in the feces of calves during their first grazing season. An entire calf crop of approximately 190 animals was monitored monthly until weaning to verify these earlier results, and to begin to discern the basis for this phenomenon. A significant genetic effect on fecal epg values was not observed until calves had been on pasture for 2–3 months, and was demonstrable until late in the grazing season when the effect was lost. The loss of a genetic effect coincided with the appearance of significant numbers of the more highly fecund nematode species
Haemonchus placei and
Oesophagostomum radiatum, and with an apparent increase in
Ostertagia ostertagi transmission, indicating that the observed genetic control of epg values may be species specific, dose dependent or both. Calves were selected from the population, and grouped according to their epg phenotype over the grazing season as either high or low epg calves. Postmortem examination of some of these calves indicated that worm burdens in the low epg calves were 60% of those of the high epg calves. Experimental challenge inoculation of the remaining calves indicated that: (1) challenge with
Cooperia oncophora resulted in low epg calves harboring worm numbers that were 65% of those of high epg calves; (2) challenge with
O. ostertagi resulted in similar numbers of worms in both groups, but the fecundity of worms in the low epg groups was significantly lower (
P<0.05) than in the high epg group. Analysis of serum anti-
Ostertagia antibody levels in the grazing calf population showed rises in serum IgG1, IgG2, IgM and IgA antibody levels during the grazing season. Peak serum IgG2 and IgG1 anti-
Ostertagia antibody levels were found to be significantly affected by host genetic factors while IgA and IgM levels were not under such control.</description><subject>Animals</subject><subject>Antibodies, Helminth - biosynthesis</subject><subject>APPAREIL DIGESTIF</subject><subject>Breeding</subject><subject>CALVES</subject><subject>Cattle</subject><subject>Cattle Diseases - genetics</subject><subject>Cattle Diseases - immunology</subject><subject>Cohort Studies</subject><subject>CONTROL DE NEMATODOS</subject><subject>CONTROL GENETICO</subject><subject>COOPERIA ONCOPHORA</subject><subject>DIGESTIVE SYSTEM</subject><subject>FAECES</subject><subject>FECES</subject><subject>Feces - parasitology</subject><subject>Female</subject><subject>FENOTIPOS</subject><subject>GENETIC CONTROL</subject><subject>HAEMONCHUS</subject><subject>Haemonchus placei</subject><subject>HECES</subject><subject>IMMUNITE</subject><subject>IMMUNITY</subject><subject>Immunity, Active - genetics</subject><subject>Immunoglobulins - biosynthesis</subject><subject>INFECCIONES POR NEMATODOS</subject><subject>INMUNIDAD</subject><subject>INSPECCION POSTMORTEM</subject><subject>Intestinal Diseases, Parasitic - genetics</subject><subject>Intestinal Diseases, Parasitic - immunology</subject><subject>Intestinal Diseases, Parasitic - veterinary</subject><subject>LUTTE ANTINEMATODE</subject><subject>LUTTE GENETIQUE</subject><subject>Male</subject><subject>NECROPSIE</subject><subject>NEMATODE CONTROL</subject><subject>NEMATODE INFECTIONS</subject><subject>Nematode Infections - genetics</subject><subject>Nematode Infections - immunology</subject><subject>Nematode Infections - veterinary</subject><subject>NEMATODOSE</subject><subject>OESOPHAGOSTOMUM RADIATUM</subject><subject>Ostertagia - immunology</subject><subject>Ostertagia - isolation & purification</subject><subject>OSTERTAGIA OSTERTAGI</subject><subject>Ostertagiasis - genetics</subject><subject>Ostertagiasis - immunology</subject><subject>Ostertagiasis - veterinary</subject><subject>OVA</subject><subject>OVULE</subject><subject>OVULO</subject><subject>Parasite Egg Count - veterinary</subject><subject>PHENOTYPE</subject><subject>PHENOTYPES</subject><subject>POSTMORTEM EXAMINATION</subject><subject>SISTEMA DIGESTIVO</subject><subject>TERNERO</subject><subject>VEAU</subject><issn>0304-4017</issn><issn>1873-2550</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1rFTEUhoMo7W31D4iFWUm7GHuSyedGkEtbhYtu6qabkGZOSmRmUpNcof_eXO-ly7o6kPc5H3kI-UDhEwUqL2EA3nOg6tzAhQEA09-9Iiuq1dAzIeA1WT0jx-SklF-N4SDVETliTCrF1Iqsb3DBGn3n01JzmroUujjP2yXWp66m7sGV9hyXiqXGxU3dgrOracSyI72rdcK35E1wU8F3h3pKfl5f3a6_9psfN9_WXza950LXnjPDgzQeJHVeCvTMUToCBu_4wHyg8t55iu1rgxicUgMGJUatjdZBKBDDKfm4n_uY0-9tO8jOsXicJrdg2hargRrJhfkvSCVwpg00kO9Bn1MpGYN9zHF2-clSsDvJdmfQ7gxaA_afZHvX2s4O87f3M47PTQerLX-_z4NL1j3kWOz3jaEAmskWft6H2FT9iZht8REXj2PM6KsdU3x5-18itZM9</recordid><startdate>19901101</startdate><enddate>19901101</enddate><creator>Gasbarre, Louis C.</creator><creator>Leighton, Eldin A.</creator><creator>Davies, Christopher J.</creator><general>Elsevier B.V</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19901101</creationdate><title>Genetic control of immunity to gastrointestinal nematodes of cattle</title><author>Gasbarre, Louis C. ; Leighton, Eldin A. ; Davies, Christopher J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c458t-4294f69c061ac65ec2a11d0efca432cf16bac1e016353a773ef75d88988f57053</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Animals</topic><topic>Antibodies, Helminth - biosynthesis</topic><topic>APPAREIL DIGESTIF</topic><topic>Breeding</topic><topic>CALVES</topic><topic>Cattle</topic><topic>Cattle Diseases - genetics</topic><topic>Cattle Diseases - immunology</topic><topic>Cohort Studies</topic><topic>CONTROL DE NEMATODOS</topic><topic>CONTROL GENETICO</topic><topic>COOPERIA ONCOPHORA</topic><topic>DIGESTIVE SYSTEM</topic><topic>FAECES</topic><topic>FECES</topic><topic>Feces - parasitology</topic><topic>Female</topic><topic>FENOTIPOS</topic><topic>GENETIC CONTROL</topic><topic>HAEMONCHUS</topic><topic>Haemonchus placei</topic><topic>HECES</topic><topic>IMMUNITE</topic><topic>IMMUNITY</topic><topic>Immunity, Active - genetics</topic><topic>Immunoglobulins - biosynthesis</topic><topic>INFECCIONES POR NEMATODOS</topic><topic>INMUNIDAD</topic><topic>INSPECCION POSTMORTEM</topic><topic>Intestinal Diseases, Parasitic - genetics</topic><topic>Intestinal Diseases, Parasitic - immunology</topic><topic>Intestinal Diseases, Parasitic - veterinary</topic><topic>LUTTE ANTINEMATODE</topic><topic>LUTTE GENETIQUE</topic><topic>Male</topic><topic>NECROPSIE</topic><topic>NEMATODE CONTROL</topic><topic>NEMATODE INFECTIONS</topic><topic>Nematode Infections - genetics</topic><topic>Nematode Infections - immunology</topic><topic>Nematode Infections - veterinary</topic><topic>NEMATODOSE</topic><topic>OESOPHAGOSTOMUM RADIATUM</topic><topic>Ostertagia - immunology</topic><topic>Ostertagia - isolation & purification</topic><topic>OSTERTAGIA OSTERTAGI</topic><topic>Ostertagiasis - genetics</topic><topic>Ostertagiasis - immunology</topic><topic>Ostertagiasis - veterinary</topic><topic>OVA</topic><topic>OVULE</topic><topic>OVULO</topic><topic>Parasite Egg Count - veterinary</topic><topic>PHENOTYPE</topic><topic>PHENOTYPES</topic><topic>POSTMORTEM EXAMINATION</topic><topic>SISTEMA DIGESTIVO</topic><topic>TERNERO</topic><topic>VEAU</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gasbarre, Louis C.</creatorcontrib><creatorcontrib>Leighton, Eldin A.</creatorcontrib><creatorcontrib>Davies, Christopher J.</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Veterinary parasitology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gasbarre, Louis C.</au><au>Leighton, Eldin A.</au><au>Davies, Christopher J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genetic control of immunity to gastrointestinal nematodes of cattle</atitle><jtitle>Veterinary parasitology</jtitle><addtitle>Vet Parasitol</addtitle><date>1990-11-01</date><risdate>1990</risdate><volume>37</volume><issue>3</issue><spage>257</spage><epage>272</epage><pages>257-272</pages><issn>0304-4017</issn><eissn>1873-2550</eissn><abstract>Previous studies have indicated that host genetics significantly affects the number of gastrointestinal nematode eggs per gram (epg) in the feces of calves during their first grazing season. An entire calf crop of approximately 190 animals was monitored monthly until weaning to verify these earlier results, and to begin to discern the basis for this phenomenon. A significant genetic effect on fecal epg values was not observed until calves had been on pasture for 2–3 months, and was demonstrable until late in the grazing season when the effect was lost. The loss of a genetic effect coincided with the appearance of significant numbers of the more highly fecund nematode species
Haemonchus placei and
Oesophagostomum radiatum, and with an apparent increase in
Ostertagia ostertagi transmission, indicating that the observed genetic control of epg values may be species specific, dose dependent or both. Calves were selected from the population, and grouped according to their epg phenotype over the grazing season as either high or low epg calves. Postmortem examination of some of these calves indicated that worm burdens in the low epg calves were 60% of those of the high epg calves. Experimental challenge inoculation of the remaining calves indicated that: (1) challenge with
Cooperia oncophora resulted in low epg calves harboring worm numbers that were 65% of those of high epg calves; (2) challenge with
O. ostertagi resulted in similar numbers of worms in both groups, but the fecundity of worms in the low epg groups was significantly lower (
P<0.05) than in the high epg group. Analysis of serum anti-
Ostertagia antibody levels in the grazing calf population showed rises in serum IgG1, IgG2, IgM and IgA antibody levels during the grazing season. Peak serum IgG2 and IgG1 anti-
Ostertagia antibody levels were found to be significantly affected by host genetic factors while IgA and IgM levels were not under such control.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>2267727</pmid><doi>10.1016/0304-4017(90)90009-Z</doi><tpages>16</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0304-4017 |
| ispartof | Veterinary parasitology, 1990-11, Vol.37 (3), p.257-272 |
| issn | 0304-4017 1873-2550 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_80196459 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals Antibodies, Helminth - biosynthesis APPAREIL DIGESTIF Breeding CALVES Cattle Cattle Diseases - genetics Cattle Diseases - immunology Cohort Studies CONTROL DE NEMATODOS CONTROL GENETICO COOPERIA ONCOPHORA DIGESTIVE SYSTEM FAECES FECES Feces - parasitology Female FENOTIPOS GENETIC CONTROL HAEMONCHUS Haemonchus placei HECES IMMUNITE IMMUNITY Immunity, Active - genetics Immunoglobulins - biosynthesis INFECCIONES POR NEMATODOS INMUNIDAD INSPECCION POSTMORTEM Intestinal Diseases, Parasitic - genetics Intestinal Diseases, Parasitic - immunology Intestinal Diseases, Parasitic - veterinary LUTTE ANTINEMATODE LUTTE GENETIQUE Male NECROPSIE NEMATODE CONTROL NEMATODE INFECTIONS Nematode Infections - genetics Nematode Infections - immunology Nematode Infections - veterinary NEMATODOSE OESOPHAGOSTOMUM RADIATUM Ostertagia - immunology Ostertagia - isolation & purification OSTERTAGIA OSTERTAGI Ostertagiasis - genetics Ostertagiasis - immunology Ostertagiasis - veterinary OVA OVULE OVULO Parasite Egg Count - veterinary PHENOTYPE PHENOTYPES POSTMORTEM EXAMINATION SISTEMA DIGESTIVO TERNERO VEAU |
| title | Genetic control of immunity to gastrointestinal nematodes of cattle |
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