A sensitive method of screening for dominant T cell clones by amplification of T cell gamma gene rearrangements with the polymerase chain reaction

A sensitive method of screening for dominant T cell clones in small samples of DNA has been developed using the polymerase chain reaction to amplify and identify T cell gamma receptor gene rearrangements. It can detect such rearrangements in nanogram quantities of DNA from cultured T cell clones, ev...

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Veröffentlicht in:	The Journal of pathology 1990-11, Vol.162 (3), p.191-196
Hauptverfasser:	Goudie, R. B., Karim, Sabeeha N., Mills, K., Alcorn, M., Lee, F. D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Biological and medical sciences Cell Line Clone Cells - cytology DNA - analysis Electrophoresis, Polyacrylamide Gel Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor Hematologic and hematopoietic diseases Humans Lymphoma - genetics Medical sciences Molecular Sequence Data polymerase chain reaction Polymerase Chain Reaction - methods T cell lymphoma T-cell rearranging gamma genes T-cell receptor gene rearrangement T-lymphocyte clone T-Lymphocytes - cytology
Online-Zugang:	Volltext
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