Alteration in breathing of the awake rat after laryngeal and diaphragmatic muscle paralysis
The respiratory rate (f), tidal volume ( Vt) and ventilation (V̇) were measured in 3 groups of rats: 10 rats before and after cutting both recurrent laryngeal nerves (RLNX), 10 rats before and after bilateral phrenicotomy (PNX) and 5 sham transected (SHAMX) rats. All rats were exposed to air and gas...
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| Veröffentlicht in: | Respiration physiology 1990-08, Vol.81 (2), p.203-212 |
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| creator | Maskrey, M. Megirian, D. Sherrey, J.H. |
| description | The respiratory rate (f), tidal volume (
Vt) and ventilation (V̇) were measured in 3 groups of rats: 10 rats before and after cutting both recurrent laryngeal nerves (RLNX), 10 rats before and after bilateral phrenicotomy (PNX) and 5 sham transected (SHAMX) rats. All rats were exposed to air and gas mixtures, deficient in O
2 and/or enriched with CO
2. The barometric method was used to measure ventilatory parameters. The sham operation did not affect breathing pattern or ventilation. In RLNX rats, breathing the various gas mixtures exhibited no changes in V̇ because f uniformly increased as
Vt declined. Therefore, loss of the neural control of the respiratory function of the larynx in awake rats exposed to selected gas mixtures has no untoward effects on alveolar ventilation. Changes in ventilation of PNX ratsm compared with SHAMX rats, depends on the gas composition breathed. With increasing severity of hypoxia and/or hypercapnia, PNX rats show a marked reduction in alveolar ventilation over that the SHAMX rats. Thus, when the diaphragm is no longer able to participate in ventilatory responses, gas exchange is likely to become deficient. |
| doi_str_mv | 10.1016/0034-5687(90)90046-2 |
| format | Article |
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Vt) and ventilation (V̇) were measured in 3 groups of rats: 10 rats before and after cutting both recurrent laryngeal nerves (RLNX), 10 rats before and after bilateral phrenicotomy (PNX) and 5 sham transected (SHAMX) rats. All rats were exposed to air and gas mixtures, deficient in O
2 and/or enriched with CO
2. The barometric method was used to measure ventilatory parameters. The sham operation did not affect breathing pattern or ventilation. In RLNX rats, breathing the various gas mixtures exhibited no changes in V̇ because f uniformly increased as
Vt declined. Therefore, loss of the neural control of the respiratory function of the larynx in awake rats exposed to selected gas mixtures has no untoward effects on alveolar ventilation. Changes in ventilation of PNX ratsm compared with SHAMX rats, depends on the gas composition breathed. With increasing severity of hypoxia and/or hypercapnia, PNX rats show a marked reduction in alveolar ventilation over that the SHAMX rats. Thus, when the diaphragm is no longer able to participate in ventilatory responses, gas exchange is likely to become deficient.</description><identifier>ISSN: 0034-5687</identifier><identifier>DOI: 10.1016/0034-5687(90)90046-2</identifier><identifier>PMID: 2263783</identifier><identifier>CODEN: RSPYAK</identifier><language>eng</language><publisher>Shannon: Elsevier B.V</publisher><subject>Air breathing ; Airway Resistance ; Animal, rat ; Animals ; Biological and medical sciences ; Control of breathing, pattern of breathing ; Fundamental and applied biological sciences. Psychology ; Hypercapnia - physiopathology ; Hypoxia - physiopathology ; Laryngeal Nerves - surgery ; Male ; Pattern of Breathing, effects of muscle paralysis ; Phrenic nerve ; Phrenic Nerve - surgery ; Pulmonary Ventilation ; Rats ; Rats, Inbred Strains ; Recurrent pharyngel nerve ; Respiration ; Respiratory muscles, effects of paralysis on respiration ; Respiratory Paralysis - physiopathology ; Respiratory system: anatomy, metabolism, gas exchange, ventilatory mechanics, respiratory hemodynamics ; Tidal Volume ; Vertebrates: respiratory system ; Vocal Cord Paralysis - physiopathology ; Wakefulness - physiology</subject><ispartof>Respiration physiology, 1990-08, Vol.81 (2), p.203-212</ispartof><rights>1990</rights><rights>1990 INIST-CNRS</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-a8e6ffe536f9f2a2bed01f6163fcfb90bc7a4a5743e6b0a3fe22bd47a3b3bd823</citedby><cites>FETCH-LOGICAL-c386t-a8e6ffe536f9f2a2bed01f6163fcfb90bc7a4a5743e6b0a3fe22bd47a3b3bd823</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6948393$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2263783$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Maskrey, M.</creatorcontrib><creatorcontrib>Megirian, D.</creatorcontrib><creatorcontrib>Sherrey, J.H.</creatorcontrib><title>Alteration in breathing of the awake rat after laryngeal and diaphragmatic muscle paralysis</title><title>Respiration physiology</title><addtitle>Respir Physiol</addtitle><description>The respiratory rate (f), tidal volume (
Vt) and ventilation (V̇) were measured in 3 groups of rats: 10 rats before and after cutting both recurrent laryngeal nerves (RLNX), 10 rats before and after bilateral phrenicotomy (PNX) and 5 sham transected (SHAMX) rats. All rats were exposed to air and gas mixtures, deficient in O
2 and/or enriched with CO
2. The barometric method was used to measure ventilatory parameters. The sham operation did not affect breathing pattern or ventilation. In RLNX rats, breathing the various gas mixtures exhibited no changes in V̇ because f uniformly increased as
Vt declined. Therefore, loss of the neural control of the respiratory function of the larynx in awake rats exposed to selected gas mixtures has no untoward effects on alveolar ventilation. Changes in ventilation of PNX ratsm compared with SHAMX rats, depends on the gas composition breathed. With increasing severity of hypoxia and/or hypercapnia, PNX rats show a marked reduction in alveolar ventilation over that the SHAMX rats. Thus, when the diaphragm is no longer able to participate in ventilatory responses, gas exchange is likely to become deficient.</description><subject>Air breathing</subject><subject>Airway Resistance</subject><subject>Animal, rat</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Control of breathing, pattern of breathing</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hypercapnia - physiopathology</subject><subject>Hypoxia - physiopathology</subject><subject>Laryngeal Nerves - surgery</subject><subject>Male</subject><subject>Pattern of Breathing, effects of muscle paralysis</subject><subject>Phrenic nerve</subject><subject>Phrenic Nerve - surgery</subject><subject>Pulmonary Ventilation</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Recurrent pharyngel nerve</subject><subject>Respiration</subject><subject>Respiratory muscles, effects of paralysis on respiration</subject><subject>Respiratory Paralysis - physiopathology</subject><subject>Respiratory system: anatomy, metabolism, gas exchange, ventilatory mechanics, respiratory hemodynamics</subject><subject>Tidal Volume</subject><subject>Vertebrates: respiratory system</subject><subject>Vocal Cord Paralysis - physiopathology</subject><subject>Wakefulness - physiology</subject><issn>0034-5687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kL1OwzAURj2ASim8AUgeEIIh4MSpkyxIVcWfVIkFJgbr2rluDU5S7ATUtyehVUemK9_v-JN9CDmL2U3MYnHLGE-jqcizq4JdF4ylIkoOyHi_PiLHIXyw_iyYGJFRkgie5XxM3meuRQ-tbWpqa6o8Qruy9ZI2hrYrpPADn0h7gILpQerAb-olgqNQl7S0sF55WFZ9gaZVF7RDugYPbhNsOCGHBlzA092ckLeH-9f5U7R4eXyezxaR5rloI8hRGINTLkxhEkgUliw2IhbcaKMKpnQGKUyzlKNQDLjBJFFlmgFXXJV5wifkctu79s1Xh6GVlQ0anYMamy7InMVFOmW8B9MtqH0Tgkcj195W_Y9kzOTgUQ7C5CBMFkz-eZRD__muv1MVlvtLO4l9frHLIWhwxkOtbdhjokhzXgzY3RbD3sW3RS-DtlhrLK1H3cqysf-_4xdX3ZJM</recordid><startdate>19900801</startdate><enddate>19900801</enddate><creator>Maskrey, M.</creator><creator>Megirian, D.</creator><creator>Sherrey, J.H.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19900801</creationdate><title>Alteration in breathing of the awake rat after laryngeal and diaphragmatic muscle paralysis</title><author>Maskrey, M. ; Megirian, D. ; Sherrey, J.H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-a8e6ffe536f9f2a2bed01f6163fcfb90bc7a4a5743e6b0a3fe22bd47a3b3bd823</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Air breathing</topic><topic>Airway Resistance</topic><topic>Animal, rat</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Control of breathing, pattern of breathing</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hypercapnia - physiopathology</topic><topic>Hypoxia - physiopathology</topic><topic>Laryngeal Nerves - surgery</topic><topic>Male</topic><topic>Pattern of Breathing, effects of muscle paralysis</topic><topic>Phrenic nerve</topic><topic>Phrenic Nerve - surgery</topic><topic>Pulmonary Ventilation</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Recurrent pharyngel nerve</topic><topic>Respiration</topic><topic>Respiratory muscles, effects of paralysis on respiration</topic><topic>Respiratory Paralysis - physiopathology</topic><topic>Respiratory system: anatomy, metabolism, gas exchange, ventilatory mechanics, respiratory hemodynamics</topic><topic>Tidal Volume</topic><topic>Vertebrates: respiratory system</topic><topic>Vocal Cord Paralysis - physiopathology</topic><topic>Wakefulness - physiology</topic><toplevel>online_resources</toplevel><creatorcontrib>Maskrey, M.</creatorcontrib><creatorcontrib>Megirian, D.</creatorcontrib><creatorcontrib>Sherrey, J.H.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Respiration physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Maskrey, M.</au><au>Megirian, D.</au><au>Sherrey, J.H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Alteration in breathing of the awake rat after laryngeal and diaphragmatic muscle paralysis</atitle><jtitle>Respiration physiology</jtitle><addtitle>Respir Physiol</addtitle><date>1990-08-01</date><risdate>1990</risdate><volume>81</volume><issue>2</issue><spage>203</spage><epage>212</epage><pages>203-212</pages><issn>0034-5687</issn><coden>RSPYAK</coden><abstract>The respiratory rate (f), tidal volume (
Vt) and ventilation (V̇) were measured in 3 groups of rats: 10 rats before and after cutting both recurrent laryngeal nerves (RLNX), 10 rats before and after bilateral phrenicotomy (PNX) and 5 sham transected (SHAMX) rats. All rats were exposed to air and gas mixtures, deficient in O
2 and/or enriched with CO
2. The barometric method was used to measure ventilatory parameters. The sham operation did not affect breathing pattern or ventilation. In RLNX rats, breathing the various gas mixtures exhibited no changes in V̇ because f uniformly increased as
Vt declined. Therefore, loss of the neural control of the respiratory function of the larynx in awake rats exposed to selected gas mixtures has no untoward effects on alveolar ventilation. Changes in ventilation of PNX ratsm compared with SHAMX rats, depends on the gas composition breathed. With increasing severity of hypoxia and/or hypercapnia, PNX rats show a marked reduction in alveolar ventilation over that the SHAMX rats. Thus, when the diaphragm is no longer able to participate in ventilatory responses, gas exchange is likely to become deficient.</abstract><cop>Shannon</cop><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>2263783</pmid><doi>10.1016/0034-5687(90)90046-2</doi><tpages>10</tpages></addata></record> |
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| ispartof | Respiration physiology, 1990-08, Vol.81 (2), p.203-212 |
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| subjects | Air breathing Airway Resistance Animal, rat Animals Biological and medical sciences Control of breathing, pattern of breathing Fundamental and applied biological sciences. Psychology Hypercapnia - physiopathology Hypoxia - physiopathology Laryngeal Nerves - surgery Male Pattern of Breathing, effects of muscle paralysis Phrenic nerve Phrenic Nerve - surgery Pulmonary Ventilation Rats Rats, Inbred Strains Recurrent pharyngel nerve Respiration Respiratory muscles, effects of paralysis on respiration Respiratory Paralysis - physiopathology Respiratory system: anatomy, metabolism, gas exchange, ventilatory mechanics, respiratory hemodynamics Tidal Volume Vertebrates: respiratory system Vocal Cord Paralysis - physiopathology Wakefulness - physiology |
| title | Alteration in breathing of the awake rat after laryngeal and diaphragmatic muscle paralysis |
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