Opioid agonist and antagonist bivalent ligands as receptor probes

Bivalent ligands are molecules which contain two pharmacophores linked by a connecting chain (spanner). The present report describes the use of oxymorphamine (Oxy) and naltrexamine (Nal) as the opioid agonist and antagonist pharmacophores separated by a variable length spanner composed of succinyl-...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Life sciences (1973) 1982-01, Vol.31 (12), p.1283-1286
Hauptverfasser:	Portoghese, P.S., Ronsisvalle, G., Larson, D.L., Yim, C.B., Sayre, L.M., Takemori, A.E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Guinea Pigs In Vitro Techniques Ligands naltrexamine Naltrexone - analogs & derivatives Naltrexone - pharmacology Narcotic Antagonists - pharmacology opiates oxymorphamine Oxymorphone - analogs & derivatives Oxymorphone - pharmacology Receptors, Opioid - drug effects Structure-Activity Relationship
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!