Involvement of Natural Killer Cells in the Pathogenesis of Murine Cytomegalovirus Interstitial Pneumonitis and the Immune Response to Infection
Department of Health and Human Services, Public Health Service, Food and Drug Administration, Bureau of Biologics, Division of Virology, 8800 Rockville Pike, Bethesda, Maryland 20205, U.S.A. The significance of the natural killer (NK) cell response to murine cytomegalovirus (MCMV) infection was eval...
Gespeichert in:
| Veröffentlicht in: | Journal of general virology 1982-01, Vol.58 (1), p.173-180 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 180 |
|---|---|
| container_issue | 1 |
| container_start_page | 173 |
| container_title | Journal of general virology |
| container_volume | 58 |
| creator | Quinnan, Gerald V., Jr Manischewitz, Jody F Kirmani, Nigar |
| description | Department of Health and Human Services, Public Health Service, Food and Drug Administration, Bureau of Biologics, Division of Virology, 8800 Rockville Pike, Bethesda, Maryland 20205, U.S.A.
The significance of the natural killer (NK) cell response to murine cytomegalovirus (MCMV) infection was evaluated in C3H/HeN mice. This strain was selected for study after preliminary demonstration that the NK cell response, occurring between 3 and 6 days post-infection was relatively high in comparison to other mouse strains studied. A doseresponse effect of hydrocortisone treatment on suppression of this response was found. A dose of hydrocortisone, given subcutaneously on two successive days, which was found to markedly inhibit the NK cell response, had no effect on development of serum interferon or antibody levels, or spleen cytotoxic T cell activity under the conditions studied. Suppression of the NK cell response by this treatment, however, was accompanied by enhanced spleen and pulmonary virus replication in vivo and increased susceptibility of mice to lethal infection. MCMV interstitial pneumonitis was characterized histologically and lung lymphocytes studied at 4 days post-infection were found to have increased NK cell activity. Treatment of mice with hydrocortisone was found to inhibit development of gross and histological evidence of pneumonitis. These findings indicate that NK cells are involved in the pathogenesis of MCMV interstitial pneumonitis and may function early in infection to restrict the extent of virus replication.
Keywords: MCMV, LCMV, immunopathogenesis, natural killer cells
Received 5 May 1981;
accepted 7 September 1981. |
| doi_str_mv | 10.1099/0022-1317-58-1-173 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_80189460</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>15464541</sourcerecordid><originalsourceid>FETCH-LOGICAL-c405t-469b2331250188aa83328690f3f0f7333a907efd5d39f59a55c18b5a856748193</originalsourceid><addsrcrecordid>eNqFkc2OEzEQhC0EWrILL4CE5BOcBvw7Yx9RxE-0C6wQnC1n0k6MxnawPUH7FLwyDoly5dSyqupruQuhF5S8oUTrt4Qw1lFOh06qjnZ04I_QgopedqzJj9HiYniKrkv5SQgVQg5X6KpnmnHBFujPKh7SdIAAseLk8Bdb52wnfOunCTJewjQV7COuO8D3tu7SFiIUX47ez3P2EfDyoaYAWzulg89zwatYIZfqq2-c-whzSLE9CrZx84-zCmFuuW9Q9ikWwDW1jIOx-hSfoSfOTgWen-cN-vHh_fflp-7u68fV8t1dNwoiayd6vWacUyYJVcpaxTlTvSaOO-IGzrnVZAC3kRuundRWypGqtbRK9oNQVPMb9OrE3ef0a4ZSTfBlbL-1EdJcjGpcLXryXyOVohdS0GZkJ-OYUykZnNlnH2x-MJSYY13m2IY5tmGkMtS0ulro5Zk-rwNsLpFzP01_fdJ3frv77TOYdv_g24q1T6bd-0L6C-nVny0</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>15464541</pqid></control><display><type>article</type><title>Involvement of Natural Killer Cells in the Pathogenesis of Murine Cytomegalovirus Interstitial Pneumonitis and the Immune Response to Infection</title><source>MEDLINE</source><source>Microbiology Society</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Quinnan, Gerald V., Jr ; Manischewitz, Jody F ; Kirmani, Nigar</creator><creatorcontrib>Quinnan, Gerald V., Jr ; Manischewitz, Jody F ; Kirmani, Nigar</creatorcontrib><description>Department of Health and Human Services, Public Health Service, Food and Drug Administration, Bureau of Biologics, Division of Virology, 8800 Rockville Pike, Bethesda, Maryland 20205, U.S.A.
The significance of the natural killer (NK) cell response to murine cytomegalovirus (MCMV) infection was evaluated in C3H/HeN mice. This strain was selected for study after preliminary demonstration that the NK cell response, occurring between 3 and 6 days post-infection was relatively high in comparison to other mouse strains studied. A doseresponse effect of hydrocortisone treatment on suppression of this response was found. A dose of hydrocortisone, given subcutaneously on two successive days, which was found to markedly inhibit the NK cell response, had no effect on development of serum interferon or antibody levels, or spleen cytotoxic T cell activity under the conditions studied. Suppression of the NK cell response by this treatment, however, was accompanied by enhanced spleen and pulmonary virus replication in vivo and increased susceptibility of mice to lethal infection. MCMV interstitial pneumonitis was characterized histologically and lung lymphocytes studied at 4 days post-infection were found to have increased NK cell activity. Treatment of mice with hydrocortisone was found to inhibit development of gross and histological evidence of pneumonitis. These findings indicate that NK cells are involved in the pathogenesis of MCMV interstitial pneumonitis and may function early in infection to restrict the extent of virus replication.
Keywords: MCMV, LCMV, immunopathogenesis, natural killer cells
Received 5 May 1981;
accepted 7 September 1981.</description><identifier>ISSN: 0022-1317</identifier><identifier>EISSN: 1465-2099</identifier><identifier>DOI: 10.1099/0022-1317-58-1-173</identifier><identifier>PMID: 6292342</identifier><language>eng</language><publisher>England: Soc General Microbiol</publisher><subject>Animals ; Cytomegalovirus Infections - complications ; Cytomegalovirus Infections - immunology ; Hydrocortisone - pharmacology ; Killer Cells, Natural - drug effects ; Killer Cells, Natural - immunology ; Lung - drug effects ; Mice ; Mice, Inbred C3H - immunology ; Pulmonary Fibrosis - etiology ; Pulmonary Fibrosis - immunology ; Spleen - drug effects</subject><ispartof>Journal of general virology, 1982-01, Vol.58 (1), p.173-180</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-469b2331250188aa83328690f3f0f7333a907efd5d39f59a55c18b5a856748193</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,3747,3748,27929,27930</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6292342$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Quinnan, Gerald V., Jr</creatorcontrib><creatorcontrib>Manischewitz, Jody F</creatorcontrib><creatorcontrib>Kirmani, Nigar</creatorcontrib><title>Involvement of Natural Killer Cells in the Pathogenesis of Murine Cytomegalovirus Interstitial Pneumonitis and the Immune Response to Infection</title><title>Journal of general virology</title><addtitle>J Gen Virol</addtitle><description>Department of Health and Human Services, Public Health Service, Food and Drug Administration, Bureau of Biologics, Division of Virology, 8800 Rockville Pike, Bethesda, Maryland 20205, U.S.A.
The significance of the natural killer (NK) cell response to murine cytomegalovirus (MCMV) infection was evaluated in C3H/HeN mice. This strain was selected for study after preliminary demonstration that the NK cell response, occurring between 3 and 6 days post-infection was relatively high in comparison to other mouse strains studied. A doseresponse effect of hydrocortisone treatment on suppression of this response was found. A dose of hydrocortisone, given subcutaneously on two successive days, which was found to markedly inhibit the NK cell response, had no effect on development of serum interferon or antibody levels, or spleen cytotoxic T cell activity under the conditions studied. Suppression of the NK cell response by this treatment, however, was accompanied by enhanced spleen and pulmonary virus replication in vivo and increased susceptibility of mice to lethal infection. MCMV interstitial pneumonitis was characterized histologically and lung lymphocytes studied at 4 days post-infection were found to have increased NK cell activity. Treatment of mice with hydrocortisone was found to inhibit development of gross and histological evidence of pneumonitis. These findings indicate that NK cells are involved in the pathogenesis of MCMV interstitial pneumonitis and may function early in infection to restrict the extent of virus replication.
Keywords: MCMV, LCMV, immunopathogenesis, natural killer cells
Received 5 May 1981;
accepted 7 September 1981.</description><subject>Animals</subject><subject>Cytomegalovirus Infections - complications</subject><subject>Cytomegalovirus Infections - immunology</subject><subject>Hydrocortisone - pharmacology</subject><subject>Killer Cells, Natural - drug effects</subject><subject>Killer Cells, Natural - immunology</subject><subject>Lung - drug effects</subject><subject>Mice</subject><subject>Mice, Inbred C3H - immunology</subject><subject>Pulmonary Fibrosis - etiology</subject><subject>Pulmonary Fibrosis - immunology</subject><subject>Spleen - drug effects</subject><issn>0022-1317</issn><issn>1465-2099</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1982</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc2OEzEQhC0EWrILL4CE5BOcBvw7Yx9RxE-0C6wQnC1n0k6MxnawPUH7FLwyDoly5dSyqupruQuhF5S8oUTrt4Qw1lFOh06qjnZ04I_QgopedqzJj9HiYniKrkv5SQgVQg5X6KpnmnHBFujPKh7SdIAAseLk8Bdb52wnfOunCTJewjQV7COuO8D3tu7SFiIUX47ez3P2EfDyoaYAWzulg89zwatYIZfqq2-c-whzSLE9CrZx84-zCmFuuW9Q9ikWwDW1jIOx-hSfoSfOTgWen-cN-vHh_fflp-7u68fV8t1dNwoiayd6vWacUyYJVcpaxTlTvSaOO-IGzrnVZAC3kRuundRWypGqtbRK9oNQVPMb9OrE3ef0a4ZSTfBlbL-1EdJcjGpcLXryXyOVohdS0GZkJ-OYUykZnNlnH2x-MJSYY13m2IY5tmGkMtS0ulro5Zk-rwNsLpFzP01_fdJ3frv77TOYdv_g24q1T6bd-0L6C-nVny0</recordid><startdate>19820101</startdate><enddate>19820101</enddate><creator>Quinnan, Gerald V., Jr</creator><creator>Manischewitz, Jody F</creator><creator>Kirmani, Nigar</creator><general>Soc General Microbiol</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19820101</creationdate><title>Involvement of Natural Killer Cells in the Pathogenesis of Murine Cytomegalovirus Interstitial Pneumonitis and the Immune Response to Infection</title><author>Quinnan, Gerald V., Jr ; Manischewitz, Jody F ; Kirmani, Nigar</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c405t-469b2331250188aa83328690f3f0f7333a907efd5d39f59a55c18b5a856748193</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1982</creationdate><topic>Animals</topic><topic>Cytomegalovirus Infections - complications</topic><topic>Cytomegalovirus Infections - immunology</topic><topic>Hydrocortisone - pharmacology</topic><topic>Killer Cells, Natural - drug effects</topic><topic>Killer Cells, Natural - immunology</topic><topic>Lung - drug effects</topic><topic>Mice</topic><topic>Mice, Inbred C3H - immunology</topic><topic>Pulmonary Fibrosis - etiology</topic><topic>Pulmonary Fibrosis - immunology</topic><topic>Spleen - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Quinnan, Gerald V., Jr</creatorcontrib><creatorcontrib>Manischewitz, Jody F</creatorcontrib><creatorcontrib>Kirmani, Nigar</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of general virology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Quinnan, Gerald V., Jr</au><au>Manischewitz, Jody F</au><au>Kirmani, Nigar</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Involvement of Natural Killer Cells in the Pathogenesis of Murine Cytomegalovirus Interstitial Pneumonitis and the Immune Response to Infection</atitle><jtitle>Journal of general virology</jtitle><addtitle>J Gen Virol</addtitle><date>1982-01-01</date><risdate>1982</risdate><volume>58</volume><issue>1</issue><spage>173</spage><epage>180</epage><pages>173-180</pages><issn>0022-1317</issn><eissn>1465-2099</eissn><abstract>Department of Health and Human Services, Public Health Service, Food and Drug Administration, Bureau of Biologics, Division of Virology, 8800 Rockville Pike, Bethesda, Maryland 20205, U.S.A.
The significance of the natural killer (NK) cell response to murine cytomegalovirus (MCMV) infection was evaluated in C3H/HeN mice. This strain was selected for study after preliminary demonstration that the NK cell response, occurring between 3 and 6 days post-infection was relatively high in comparison to other mouse strains studied. A doseresponse effect of hydrocortisone treatment on suppression of this response was found. A dose of hydrocortisone, given subcutaneously on two successive days, which was found to markedly inhibit the NK cell response, had no effect on development of serum interferon or antibody levels, or spleen cytotoxic T cell activity under the conditions studied. Suppression of the NK cell response by this treatment, however, was accompanied by enhanced spleen and pulmonary virus replication in vivo and increased susceptibility of mice to lethal infection. MCMV interstitial pneumonitis was characterized histologically and lung lymphocytes studied at 4 days post-infection were found to have increased NK cell activity. Treatment of mice with hydrocortisone was found to inhibit development of gross and histological evidence of pneumonitis. These findings indicate that NK cells are involved in the pathogenesis of MCMV interstitial pneumonitis and may function early in infection to restrict the extent of virus replication.
Keywords: MCMV, LCMV, immunopathogenesis, natural killer cells
Received 5 May 1981;
accepted 7 September 1981.</abstract><cop>England</cop><pub>Soc General Microbiol</pub><pmid>6292342</pmid><doi>10.1099/0022-1317-58-1-173</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-1317 |
| ispartof | Journal of general virology, 1982-01, Vol.58 (1), p.173-180 |
| issn | 0022-1317 1465-2099 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_80189460 |
| source | MEDLINE; Microbiology Society; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Animals Cytomegalovirus Infections - complications Cytomegalovirus Infections - immunology Hydrocortisone - pharmacology Killer Cells, Natural - drug effects Killer Cells, Natural - immunology Lung - drug effects Mice Mice, Inbred C3H - immunology Pulmonary Fibrosis - etiology Pulmonary Fibrosis - immunology Spleen - drug effects |
| title | Involvement of Natural Killer Cells in the Pathogenesis of Murine Cytomegalovirus Interstitial Pneumonitis and the Immune Response to Infection |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-13T04%3A20%3A32IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Involvement%20of%20Natural%20Killer%20Cells%20in%20the%20Pathogenesis%20of%20Murine%20Cytomegalovirus%20Interstitial%20Pneumonitis%20and%20the%20Immune%20Response%20to%20Infection&rft.jtitle=Journal%20of%20general%20virology&rft.au=Quinnan,%20Gerald%20V.,%20Jr&rft.date=1982-01-01&rft.volume=58&rft.issue=1&rft.spage=173&rft.epage=180&rft.pages=173-180&rft.issn=0022-1317&rft.eissn=1465-2099&rft_id=info:doi/10.1099/0022-1317-58-1-173&rft_dat=%3Cproquest_cross%3E15464541%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=15464541&rft_id=info:pmid/6292342&rfr_iscdi=true |