Insulin and neurodegenerative disease: shared and specific mechanisms

Insulin has functions in the brain and dysregulation of these functions may contribute to the expression of late-life neurodegenerative disease. We provide a brief summary of research on the influence of insulin on normal brain function. We then review evidence that perturbation of this role may con...

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Veröffentlicht in:	Lancet neurology 2004-03, Vol.3 (3), p.169-178
Hauptverfasser:	Craft, Suzanne, Stennis Watson, G
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Alzheimer's disease Animals Blood-brain barrier Brain - metabolism Brain - physiopathology Brain research Cognition Disorders - etiology Cognition Disorders - metabolism Cognition Disorders - physiopathology Cognitive ability Dementia Diabetes Complications Diabetes Mellitus - metabolism Diabetes Mellitus - physiopathology Energy Metabolism - physiology Glucose Humans Huntingtons disease Hypothalamus Influence Insulin - metabolism Insulin resistance Kinases Memory Metabolism Neurodegenerative Diseases - metabolism Neurodegenerative Diseases - physiopathology Neurons Parkinson's disease Receptor, Insulin - metabolism Signal Transduction - physiology
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