The influence of chronic treatment with verapamil on plasma atrial natriuretic peptide levels in young elderly hypertensive patients
In a double-blind, placebo-controlled cross-over study, the plasma atrial natriuretic peptide (ANP) levels of nine young and ten elderly hypertensive patients were compared after placebo and after treatment with 120 mg verapamil given three times daily over 4 weeks. During placebo, plasma ANP levels...
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Veröffentlicht in: | European journal of clinical pharmacology 1990-01, Vol.39 (1), p.S39-S40 |
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container_title | European journal of clinical pharmacology |
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creator | VAN BORTEL, L. M. A. B SCHIFFERS, P. M. H BÖHM, R. O. B MOOIJ, J. M. V RAHN, K. H STRUYKER-BOUDIER, H. A. J |
description | In a double-blind, placebo-controlled cross-over study, the plasma atrial natriuretic peptide (ANP) levels of nine young and ten elderly hypertensive patients were compared after placebo and after treatment with 120 mg verapamil given three times daily over 4 weeks. During placebo, plasma ANP levels proved to be higher in elderly patients than in young subjects. Chronic treatment with verapamil induced a rise in ANP levels in both young and elderly patients with hypertension. |
doi_str_mv | 10.1007/BF01409206 |
format | Article |
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M. A. B ; SCHIFFERS, P. M. H ; BÖHM, R. O. B ; MOOIJ, J. M. V ; RAHN, K. H ; STRUYKER-BOUDIER, H. A. J</creator><creatorcontrib>VAN BORTEL, L. M. A. B ; SCHIFFERS, P. M. H ; BÖHM, R. O. B ; MOOIJ, J. M. V ; RAHN, K. H ; STRUYKER-BOUDIER, H. A. J</creatorcontrib><description>In a double-blind, placebo-controlled cross-over study, the plasma atrial natriuretic peptide (ANP) levels of nine young and ten elderly hypertensive patients were compared after placebo and after treatment with 120 mg verapamil given three times daily over 4 weeks. During placebo, plasma ANP levels proved to be higher in elderly patients than in young subjects. Chronic treatment with verapamil induced a rise in ANP levels in both young and elderly patients with hypertension.</description><identifier>ISSN: 0031-6970</identifier><identifier>EISSN: 1432-1041</identifier><identifier>DOI: 10.1007/BF01409206</identifier><identifier>PMID: 2148150</identifier><language>eng</language><publisher>Heidelberg: Springer</publisher><subject>Adult ; Aged ; Antihypertensive agents ; Atrial Natriuretic Factor - blood ; Biological and medical sciences ; Blood Pressure - drug effects ; Cardiovascular system ; Double-Blind Method ; Humans ; Hypertension - blood ; Hypertension - drug therapy ; Medical sciences ; Middle Aged ; Pharmacology. 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Chronic treatment with verapamil induced a rise in ANP levels in both young and elderly patients with hypertension.</description><subject>Adult</subject><subject>Aged</subject><subject>Antihypertensive agents</subject><subject>Atrial Natriuretic Factor - blood</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure - drug effects</subject><subject>Cardiovascular system</subject><subject>Double-Blind Method</subject><subject>Humans</subject><subject>Hypertension - blood</subject><subject>Hypertension - drug therapy</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pharmacology. 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B</creatorcontrib><creatorcontrib>SCHIFFERS, P. M. H</creatorcontrib><creatorcontrib>BÖHM, R. O. B</creatorcontrib><creatorcontrib>MOOIJ, J. M. V</creatorcontrib><creatorcontrib>RAHN, K. H</creatorcontrib><creatorcontrib>STRUYKER-BOUDIER, H. A. J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of clinical pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>VAN BORTEL, L. M. A. B</au><au>SCHIFFERS, P. M. H</au><au>BÖHM, R. O. B</au><au>MOOIJ, J. M. V</au><au>RAHN, K. H</au><au>STRUYKER-BOUDIER, H. A. J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The influence of chronic treatment with verapamil on plasma atrial natriuretic peptide levels in young elderly hypertensive patients</atitle><jtitle>European journal of clinical pharmacology</jtitle><addtitle>Eur J Clin Pharmacol</addtitle><date>1990-01-01</date><risdate>1990</risdate><volume>39</volume><issue>1</issue><spage>S39</spage><epage>S40</epage><pages>S39-S40</pages><issn>0031-6970</issn><eissn>1432-1041</eissn><abstract>In a double-blind, placebo-controlled cross-over study, the plasma atrial natriuretic peptide (ANP) levels of nine young and ten elderly hypertensive patients were compared after placebo and after treatment with 120 mg verapamil given three times daily over 4 weeks. During placebo, plasma ANP levels proved to be higher in elderly patients than in young subjects. Chronic treatment with verapamil induced a rise in ANP levels in both young and elderly patients with hypertension.</abstract><cop>Heidelberg</cop><cop>Berlin</cop><pub>Springer</pub><pmid>2148150</pmid><doi>10.1007/BF01409206</doi></addata></record> |
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subjects | Adult Aged Antihypertensive agents Atrial Natriuretic Factor - blood Biological and medical sciences Blood Pressure - drug effects Cardiovascular system Double-Blind Method Humans Hypertension - blood Hypertension - drug therapy Medical sciences Middle Aged Pharmacology. Drug treatments Time Factors Verapamil - administration & dosage Verapamil - therapeutic use |
title | The influence of chronic treatment with verapamil on plasma atrial natriuretic peptide levels in young elderly hypertensive patients |
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